Photobiomodulation effects on mRNA levels from genomic and chromosome stabilization genes in injured muscle

Trajano, Larissa Alexsandra da Silva Neto; Trajano, Eduardo Tavares Lima; Sergio, Luiz Philippe da Silva; Teixeira, Adilson Fonseca; Mencalha, André Luiz; Stumbo, Ana Carolina; Fonseca, Adenilson de Souza da

doi:10.1007/s10103-018-2510-0

Cited by 9 publications

(4 citation statements)

References 48 publications

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“…Experimental animal research (Table 3) supports the beneficial effects of PBM applied before and after exercise in physical activity, through improved performance in endurance training [78,79], decreased level of proinflammatory cytokines [80][81][82][83][84], positive effects on aerobic metabolism [85,86], oxidative stress [86][87][88] and increased ATP [89,90]. Histopathological examination performed after PBM showed that it can protect myonecrosis, reduce pro-inflammatory cell infiltration, muscle destruction, inflammation and can help accelerate tissue repair [91][92][93].…”

Section: Discussionmentioning

confidence: 83%

Photobiomodulation and Sports: Results of a Narrative Review

Ailioaie

Litscher

2021

Life

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Benefits of photobiomodulation (PBM) have been known for several decades. More recently, PBM applied in sports offers a special chance to support the modeling of the performance and recovery. Increasingly complex physical activities and fierce competition in the world of sports generate a state of psycho-emotional and physical stress that can induce chronic fatigue syndrome, failure in physical training, predisposition to muscle damage, physical and emotional exhaustion etc., for which PBM could be an excellent solution. To evaluate and identify all risk factors and the influence of PBM on health and performance in sport and for a better understanding of its effects, we did a search for “Photobiomodulation and Sports” on PubMed, to update the PBM science applied in sports, and we retained for analysis the articles published from 2014 to date. The term “PBM” is recent, and we did not include previous studies with “low level laser therapy” or “LLLT” before 2014. In the present research, PBM has been shown to have valuable protective and ergogenic effects in 25 human studies, being the key to success for high performance and recovery, facts supported also by 22 animal studies. PBM applied creatively and targeted depending on sport and size of the level of physical effort could perfectly modulate the mitochondrial activity and thus lead to remarkable improvements in performance. PBM with no conclusive results or without effects from this review (14 studies from a total of 39 on humans) was analyzed and we found the motivations of the authors from the perspective of multiple causes related to technological limitations, participants, the protocols for physical activity, the devices, techniques and PBM parameters. In the near future, dose–response experiments on physical activity should be designed and correlated with PBM dose–response studies, so that quantification of PBM parameters to allow the energy, metabolic, immune, and neuro-endocrine modulation, perfectly coupled with the level of training. There is an urgent need to continuously improve PBM devices, delivery methods, and protocols in new ingenious future sports trials. Latest innovations and nanotechnologies applied to perform intracellular signaling analysis, while examining extracellular targets, coupled with 3D and 4D sports motion analysis and other high-tech devices, can be a challenge to learn how to maximize PBM efficiency while achieving unprecedented sports performance and thus fulfilling the dream of millions of elite athletes.

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Section: Discussionmentioning

confidence: 83%

Photobiomodulation and Sports: Results of a Narrative Review

Ailioaie

Litscher

2021

Life

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“…Previous studies have demonstrated modulation of mRNA levels from shelterin complex genes after exposure to a low-power infrared laser [ 23 , 24 ]. These lasers are considered safe and effective nonionizing sources with well-established photobiomodulation effect on cells and tissues in the so-called therapeutic window [ 25 , 26 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…In a study, it was demonstrated that exposure to a low-power infrared laser increases the mRNA levels of TRF1 and TRF2 genes in myoblasts, which can conibute to telomere stabilization [ 23 ]. In another study, mRNA relative levels of TRF1 and TRF2 genes were modulated by a low-power infrared laser in injured skeletal muscle in an experimental model of muscle injury [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although the effects of low-power infrared lasers on the telomere stability in cells and tissue have been evaluated [ 23 , 24 ], no studies have been carried out to evaluate the photobiostimulation effect of a low-power infrared laser on the telomere stabilization in healthy or diseased heart tissue. Thus, this study aimed to evaluate effect of a low-power infrared laser on mRNA relative levels of genes involved in telomere stabilization and telomere length in heart tissue from an experimental model of acute lung injury by sepsis.…”

Section: Introductionmentioning

confidence: 99%

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Low-power infrared laser modulates telomere length in heart tissue from an experimental model of acute lung injury

Trajano

Sergio

Oliveira

et al. 2021

Photochem Photobiol Sci

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Acute lung injury and acute respiratory distress syndrome can occur as a result of sepsis. Cardiac dysfunction is a serious component of multi-organ failure caused by severe sepsis. Telomere shortening is related to several heart diseases. Telomeres are associated with the shelterin protein complex, which contributes to the maintenance of telomere length. Low-power infrared lasers modulate mRNA levels of shelterin complex genes. This study aimed to evaluate effects of a low-power infrared laser on mRNA relative levels of genes involved in telomere stabilization and telomere length in heart tissue of an experimental model of acute lung injury caused by sepsis. Animals were divided into six groups, treated with intraperitoneal saline solution, saline solution and exposed to a low-power infrared laser at 10 J cm −2 and 20 J cm −2 , lipopolysaccharide (LPS), and LPS and, after 4 h, exposed to a low-power infrared laser at 10 J cm −2 and 20 J cm −2 . The laser exposure was performed only once. Analysis of mRNA relative levels and telomere length by RT-qPCR was performed. Telomere shortening and reduction in mRNA relative levels of TRF1 mRNA in heart tissues of LPS-induced ALI animals were observed. In addition, laser exposure increased the telomere length at 10 J cm −2 and modulated the TRF1 mRNA relative levels of at 20 J cm −2 in healthy animals. Although the telomeres were shortened and mRNA levels of TRF1 gene were increased in nontreated controls, the low-power infrared laser irradiation increased the telomere length at 10 J cm −2 in cardiac tissue of animals affected by LPS-induced acute lung injury, which suggests that telomere maintenance is a part of the photobiomodulation effect induced by infrared radiation.

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The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

Alam,

Karami,

Mohammadikhah

et al. 2024

Cell Biochemistry & Function

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The use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. The effects of PBMT on maxillofacial injuries were discussed in this review article. The electronic databases Pubmed, Scopus, and Web of Science were thoroughly searched. This review included in vitro, in vivo, and clinical studies describing how PBMT can be used in maxillofacial tissue engineering and regenerative medicine. Some studies suggest that PBMT may offer a promising therapy for traumatic maxillofacial injuries because it can stimulate the differentiation and proliferation of various cells, including dental pulp cells and mesenchymal stem cells, enhancing bone regeneration and osseointegration. PBMT reduces pain and swelling after oral surgery and tooth extraction in human and animal models of maxillofacial injuries. Patients with temporomandibular disorders also benefit from PBMT in terms of reduced inflammation and symptoms. PBMT still has some limitations, such as the need for standardizing parameters. PBMT must also be evaluated further in randomized controlled trials in various maxillofacial injuries. As a result, PBMT offers a safe and noninvasive treatment option for patients suffering from traumatic maxillofacial injuries. PBMT still requires further research to establish its efficacy in clinical practice and determine the optimal parameters.

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Photobiomodulation effects on mRNA levels from genomic and chromosome stabilization genes in injured muscle

Cited by 9 publications

References 48 publications

Photobiomodulation and Sports: Results of a Narrative Review

Photobiomodulation and Sports: Results of a Narrative Review

Low-power infrared laser modulates telomere length in heart tissue from an experimental model of acute lung injury

The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

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