Photobiomodulation for pain relief: Model-based estimates of effective doses of light at the neural target

Buzza, Andrew; Tapas, Kalista; Anders, Juanita; Jenkins, Michael; Moffitt, Michael

doi:10.1016/j.jphotobiol.2024.112929

Journal of Photochemistry and Photobiology B: Biology

2024

DOI: 10.1016/j.jphotobiol.2024.112929

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Photobiomodulation for pain relief: Model-based estimates of effective doses of light at the neural target

Andrew Buzza,

Kalista Tapas,

Juanita Anders

et al.

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2024

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Cited by 1 publication

References 60 publications

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Treatment of neuropathic pain in leprosy patients with a physiotherapeutic protocol combined with photobiomodulation

Bonazza,

Duarte,

Lima

et al. 2024

Preprint

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Purpose: Leprosy, when diagnosed late, often leads to persistent complications, including neuropathic pain due to Mycobacterium leprae infection. This study aimed to apply a physiotherapeutic protocol combined with photobiomodulation as a non-pharmacological resource to reduce neuropathic pain and maintain functional capacity in leprosy patients. Methods: A single-blind randomized clinical trial was conducted with 30 leprosy patients. Patients were randomly divided into two groups: physiotherapeutic protocol (PPG) and physiotherapeutic protocol combined with photobiomodulation (PPBMG). They were analyzed for pain scale (VAS), screening of activity limitation and safety awareness (SALSA), participation scale, and quality of life survey (SF-36). Results: In the SALSA, a reduction in the number of patients with very severe limitation was observed in the PPBMG (effect size, 0.24). In participation scale, there was an increase in the number of patients without restrictions in the PPBMG. Regarding VAS, there was improvement in both groups (PPG, P=0.0061; PPBMG, P=0.041), with no difference between them. In relation to neurological evaluation by nerve palpation, there was improvement in the ulnar nerve condition (P=0.0244) in the PPG group, and in the fibular nerve (P=0.0425) in the PPBMG group. In the functional assessment, PPBMG patients showed statistical differences with improvement in the median (P=0.0281) and tibial (P=0.0267) nerves. In the SF-36, there was an increase in the domains of physical limitations (PPG, P=0.0273; and PPBMG, P=0.0078) and pain (PPG, P=0.0156; and PPBMG, P=0.0020; effect size, 0.34). Conclusion: This study provides highly relevant evidence for the efficacy of PPBMG in treating neuropathic pain in leprosy patients.

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Treatment of neuropathic pain in leprosy patients with a physiotherapeutic protocol combined with photobiomodulation

Bonazza,

Duarte,

Lima

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Photobiomodulation for pain relief: Model-based estimates of effective doses of light at the neural target

Cited by 1 publication

References 60 publications

Treatment of neuropathic pain in leprosy patients with a physiotherapeutic protocol combined with photobiomodulation

Treatment of neuropathic pain in leprosy patients with a physiotherapeutic protocol combined with photobiomodulation

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