Photobiomodulation in Dentistry

Tunér, Jan; Beck-Kristensen, Per Hugo; Ross, Gerald; Ross, Alana

doi:10.1016/b978-0-323-29762-2.00015-2

Cited by 7 publications

(2 citation statements)

References 127 publications

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“…Light absorption through photoreceptors within cells can lead to enhanced ATP production, cell signaling and production of growth factors. The activation of a cascade of photoreceptors, enzymes, proteins and transcription factors has been considered underlying biological mechanisms of PBM (38)(39)(40).…”

Section: Introductionmentioning

confidence: 99%

Effect of Photobiomodulation on Structure and Function of Extracellular Vesicle Secreted from Mesenchymal Stem Cells

Gholami

Khorsandi

Nooshabadi

et al. 2022

Photochem & Photobiology

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The current study intended to evaluate the effect of photobiomodulation on the morphology and function of EVs secreted from mesenchymal stem cells (MSCs) derived from periodontal ligament (PDL) and the adipose tissue (ADSCs) (from buccal fat pad) in vitro. These cells were irradiated at 660 nm or kept in dark as control. EVs were then isolated from each group using ultracentrifugation. EVs were defined by flow cytometry and Western blot. Electron microscopy (SEM) was used to study the morphology of EVs. Then, MTT and wound-healing scratch assays were applied to compare the cell survival and migration of human dermal fibroblast (HDF) cells treated with the EVs obtained from the four groups. According to SEM images, isolated EV were round and cup-shaped in all groups showing no destructive effects of laser irradiation on EV morphology. MTT test results revealed a statistically significant difference between the HDF cells treated with different EV groups from hPDLSCs-Dark in comparison with control (0 lg/mL) (P < 0.05) and treated with exosome from hPDLSCs-Irradiation cells compared with dark group (P < 0.05). However, scratch wound-healing assay did not show a significant difference between various groups (P ˃ 0.05). Further studies with different irradiation protocols are recommended to find an optimal strategy.

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Section: Introductionmentioning

confidence: 99%

Effect of Photobiomodulation on Structure and Function of Extracellular Vesicle Secreted from Mesenchymal Stem Cells

Gholami

Khorsandi

Nooshabadi

et al. 2022

Photochem & Photobiology

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“…Low Level Laser Therapy (LLLT) or photobiomodulation utilizes low to mid power with power output in the range of 50-500 mW. The light is in the region of red visible to near infrared (630-980 nm) (98). Moreover, LLLT produces lower or even no heating of tissue.…”

Section: Low Level Laser Therapymentioning

confidence: 99%

Effect of low level laser stimulation on salivary gland function in diabetic patients with hyposalivation

Wibawa

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Saliva plays several functions and the most important roles among of those are the lubrication and the protection by defensive proteins. Salivary gland hypofunction showed a high prevalence in patient with diabetes. Previous studies indicated that protein mucin 5B concentration, which is important to lubrication, tended to decrease in hyposalivation patients and a decrease in histatin 5 was found in disease with fungal infection. The several previous studies indicated that low level laser therapy (LLLT) can stimulate salivary gland function with an increase in salivary flow rate in systemic disease patients with dry mouth complication. Therefore, LLLT may be applied as the treatment choice for patients with dry mouth symptom. This study aimed to investigate the effect of low-level laser stimulation on salivary gland function in diabetic patients with hyposalivation. The assessment of salivary flow rates, mucin 5B (MUC5B), mucin 7 (MUC7), histatin 5 concentrations, and questionnaires were performed. A total of twelve diabetic patients under criteria set in this study at Bangkok Hospital were participated on a voluntary basis. A low power laser was used to stimulate major salivary glands with an irradiation time of 40 s on 6 occasions (3 times in 2 consecutive weeks). Questionnaire related to dry mouth symptoms were given. Salivary flow rates and questionnaire were assessed as well as MUC7, MUC5B, and histatin 5 protein concentration in saliva at the 1st visit, 6th visit, and 6th week follow-up visit. The unstimulated salivary flow rate and MUC5B concentration at the 6th week follow-up visit were significantly increased compare with at the 1st visit. By contrast, the concentration of histatin 5 exhibited a significant decrease at the 6th week follow-up visit compare with at the 1st visit . The mean dry mouth score revealed a significant decrease regarding to dry mouth symptoms at the 6th visit and 6th week follow-up visit compared with at the 1st visit. The correlation between overall dry mouth score and flow rate showed the strongest positive correlation at the 6th visit. There were no significant differences found on stimulated salivary flow rate and MUC7 concentration. Our results indicate a beneficial effect of LLLT on diabetic patients in increasing salivary flow rate and maintaining oral lubrication.

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Laser Use in Muco-Gingival Surgical Orthodontics

Borzabadi-Farahani

2023

Textbooks in Contemporary Dentistry

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Photobiomodulation in Dentistry

Cited by 7 publications

References 127 publications

Effect of Photobiomodulation on Structure and Function of Extracellular Vesicle Secreted from Mesenchymal Stem Cells

Effect of Photobiomodulation on Structure and Function of Extracellular Vesicle Secreted from Mesenchymal Stem Cells

Effect of low level laser stimulation on salivary gland function in diabetic patients with hyposalivation

Laser Use in Muco-Gingival Surgical Orthodontics

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