Photobiomodulation of human gingival fibroblasts with diode laser - A systematic review

Bakshi, Purva Vijay; Setty, Swati; Kulkarni, Mihir R.

doi:10.4103/jisp.jisp_90_21

Cited by 12 publications

(12 citation statements)

References 21 publications

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“…But as compared to traditional methods of assessment, these biomarkers demonstrate optimum prediction of site-specific prognosis and outcome of therapy. Although precise cutoff values for these biomarkers cannot be determined, the increase and decrease of these biomarkers serve as an important tool for assessing biological events occurring at the molecular level in the pocket lining [4,[14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…Soft tissue surgical procedures using lasers were found to achieve hemostasis and sterilization with minimal post-operative pain in contrast to conventional surgical procedures. The conclusive goal of any periodontal therapy is to attain sustainable regeneration and simultaneously ensure that the healing period is brief and comfortable for the patient [2][3][4]. Low-level laser therapy (LLLT) has also been examined recently for its effectiveness in the medical and dentistry fields' wound-healing procedures.…”

Section: Introductionmentioning

confidence: 99%

“…The bio-stimulatory and inhibitory effects of LLLT are governed by the Arndt-Schulz law, wherein low doses increase physiological processes and strong stimuli inhibit physiological activity. LLLT with a diode laser has stimulatory effects on human gingival fibroblasts, which may have beneficial effects on healing wounds [4]. Wound healing certainly starts at the moment of injury, but the complete healing phase almost lasts up to 1 or 2 years.…”

Section: Introductionmentioning

confidence: 99%

“…The tissue repair phase, which begins on the third day and lasts about two weeks, involves fibroblast proliferation and collagen genesis. The supplementation of LLLT at this point in time leads to expedited wound-healing events [4].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Low-Level Laser Therapy on Early Wound Healing and Levels of Inflammatory Mediators in Gingival Crevicular Fluid Following Open Flap Debridement

Misra¹,

Kalsi²,

Arora³

et al. 2023

Cureus

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IntroductionLow-level laser therapy (LLLT) has a beneficial effect on pain relief and wound healing. This study aims at a clinical evaluation of early wound healing and a biochemical evaluation of inflammatory mediators in gingival crevicular fluid (GCF) following LLLT with an open flap debridement (OFD) in periodontal therapy. Material and methodsThis randomized controlled trial included 40 chronic periodontitis patients with bilateral attachment loss, pocket depths of 5 mm affecting at least two quadrants, and radiographic evidence of horizontal bone loss. 120 control sites were randomly selected to receive OFD, and contralateral 120 test sites received biostimulation with a diode laser (890 nm) after OFD. The wound healing index was recorded at the 1st and 2nd weeks, and clinical parameters such as the plaque index, gingival index, pocket probing depth, clinical attachment level, and GCF inflammatory mediators were evaluated at baseline, 3, and 6 months. ResultsFrom the start of the study to 6 months later, there was a statistically significant drop in plaque index, gingival index, probing pocket depth, and gain clinical attachment levels in both groups. However, when the two groups were compared, there were no significant differences at any time intervals. GCF inflammatory mediators tumor necrosis factor (TNF) alpha and matrix metalloproteinases (MMP-8) decrease, and osteoprotegerin (OPG) levels increase in both the test group and control group from baseline to 3 months and 6 months. In intergroup comparisons, there was a statistically significant reduction in the test group as compared to the control group at 6 months. There was a decline in gingival crevicular fluid -interleukin-6 (GCF IL-6) levels from baseline to 3 months and 6 months in both the groups but when analysed statistically, the results were not significant on intergroup and intragroup comparison at any time interval. The Landry Wound Healing Index values in the 1st and 2nd weeks were showing statistically significant improved healing in the test group as compared to the control group. There was significantly better wound healing at sites where a diode laser was used. ConclusionLLLT increases early wound healing after periodontal surgical procedures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Low-Level Laser Therapy on Early Wound Healing and Levels of Inflammatory Mediators in Gingival Crevicular Fluid Following Open Flap Debridement

Misra¹,

Kalsi²,

Arora³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…The usage of diode laser leads to a more bloodless and comparatively less patient discomfort than the other procedures as it causes less damage to adjacent tissues. This was followed by photobiomodulation using 0.1 Watt, a low-intensity diode laser that has been shown to enhance the healing process along with added benefits of pain control and anti-inflammatory actions, increased fibroblastic proliferation, and collagen synthesis was seen after its usage 14 . After one month of follow-up, the patient responded well surgically and had no recurrence.…”

Section: Discussionmentioning

confidence: 99%

Application of diode laser with photobiomodulation in the excision of giant cell fibroma: A case report

Varshitha¹,

Pudakalkatti²,

Hattarki³

et al. 2022

World J. Adv. Res. Rev.

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Giant cell fibroma is relatively new and rare entity, commonly seen in gingiva. It is a benign non-neoplastic lesion of oral cavity. It manifests clinically as a slow-growing, asymptomatic, sessile or pedunculated mass with a maximum diameter of 0.5 to 1 cm. These lesions commonly occurs in young individuals and have no sex predilection. Histopathological findings of giant cell fibroma show a presence of the stellate fibroblasts with multinucleated giant cells. This report is a case of giant cell fibroma, occuring on the right buccal mucosa in a 14 year old female patient. Surgical excision of the lesion was planned using a diode laser followed by photo-biomodulation. Post surgically healing was satisfactory, with no significant scar tissue formation and follow up showed no recurrence of lesion.

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Photobiomodulation Therapy Within Clinical Dentistry: Theoretical and Applied Concepts

Cronshaw,

Mylona

2023

Textbooks in Contemporary Dentistry

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Photobiomodulation of human gingival fibroblasts with diode laser - A systematic review

Cited by 12 publications

References 21 publications

Effect of Low-Level Laser Therapy on Early Wound Healing and Levels of Inflammatory Mediators in Gingival Crevicular Fluid Following Open Flap Debridement

Effect of Low-Level Laser Therapy on Early Wound Healing and Levels of Inflammatory Mediators in Gingival Crevicular Fluid Following Open Flap Debridement

Application of diode laser with photobiomodulation in the excision of giant cell fibroma: A case report

Photobiomodulation Therapy Within Clinical Dentistry: Theoretical and Applied Concepts

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