Photobiomodulation promotes neural regeneration when compared to simvastatin treatment in a sciatic nerve crush model

Souza, Luana Gabriel de; Hendler, Ketlyn Germann; Marcolino, Alexandre Márcio; Kuriki, Heloyse Uliam; Cardoso, Ramon Bauer; Fonseca, Marisa de Cássia Registro; Barbosa, Rafael Inácio

doi:10.1007/s10103-020-03176-y

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…In addition, Yang et al found that the combination of LLLT with mesenchymal stem cells had a more significant impact on the functional recovery of a crushed sciatic nerve compared to using either therapy alone [ 106 ]. In addition, the combination of PBM with dexamethasone and simvastatin demonstrated superior efficacy compared to individual therapies in enhancing SCI outcomes [ 109 , 111 ]. In contrast, certain studies have suggested that the use of combination therapy does not result in a synergistic impact on the recovery from SCI [ 107 , 125 ].…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review

Farazi,

Salehi-Pourmehr,

Farajdokht

et al. 2024

BMC Neurol

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Preclinical and clinical studies have indicated that combining photobiomodulation (PBM) therapy with other therapeutic approaches may influence the treatment process in a variety of disorders. The purpose of this systematic review was to determine whether PBM-combined therapy provides additional benefits over monotherapies in neurologic and neuropsychiatric disorders. In addition, the review describes the most commonly used methods and PBM parameters in these conjunctional approaches.To accomplish this, a systematic search was conducted in Google Scholar, PubMed, and Scopus databases through January 2024. 95 potentially eligible articles on PBM-combined treatment strategies for neurological and neuropsychological disorders were identified, including 29 preclinical studies and 66 clinical trials.According to the findings, seven major categories of studies were identified based on disease type: neuropsychiatric diseases, neurodegenerative diseases, ischemia, nerve injury, pain, paresis, and neuropathy. These studies looked at the effects of laser therapy in combination with other therapies like pharmacotherapies, physical therapies, exercises, stem cells, and experimental materials on neurological disorders in both animal models and humans. The findings suggested that most combination therapies could produce synergistic effects, leading to better outcomes for treating neurologic and psychiatric disorders and relieving symptoms.These findings indicate that the combination of PBM may be a useful adjunct to conventional and experimental treatments for a variety of neurological and psychological disorders.

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Section: Discussionmentioning

confidence: 99%

Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review

Farazi,

Salehi-Pourmehr,

Farajdokht

et al. 2024

BMC Neurol

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“…In restorative medicine, posttraumatic PNIs repair is a major challenge since it can result in temporary or permanent sensory and/or motor harms, which can lead to eventual financial and social concerns ( Jiang et al, 2016 ). Therapeutic agents, surgical approaches, and immune system modulators have been proposed to enhance nerve regeneration ( Xavier et al, 2012 ; de Souza et al, 2021 ). However, none of the tried policies restored the preinjury motor and sensory function ( Geuna et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative neuroprotective effects of Cerebrolysin, dexamethasone, and ascorbic acid on sciatic nerve injury model: Behavioral and histopathological study

et al. 2023

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BackgroundThe majority of the suggested experimental modalities for peripheral nerve injury (PNI) result in varying degrees of recovery in animal models; however, there are not many reliable clinical pharmacological treatment models available. To alleviate PNI complications, research on approaches to accelerate peripheral nerve regeneration is encouraged. Cerebrolysin, dexamethasone, and ascorbic acid (vitamin C) drug models were selected in our study because of their reported curative effects of different mechanisms of action.MethodologyA total of 40 adult male albino rats were used in this study. Sciatic nerve crush injury was induced in 32 rats, which were divided equally into four groups (model, Cerebrolysin, dexamethasone, and vitamin C groups) and compared to the sham group (n = 8). The sciatic nerve sensory and motor function regeneration after crushing together with gastrocnemius muscle histopathological changes were evaluated by the sciatic function index, the hot plate test, gastrocnemius muscle mass ratio, and immune expression of S100 and apoptosis cascade (BAX, BCL2, and BAX/BCL2 ratio).ResultsSignificant improvement of the behavioral status and histopathological assessment scores occurred after the use of Cerebrolysin (as a neurotrophic factor), dexamethasone (as an anti-inflammatory), and vitamin C (as an antioxidant). Despite these seemingly concomitant, robust behavioral and pathological changes, vitamin C appeared to have the best results among the three main outcome measures. There was a positive correlation between motor and sensory improvement and also between behavioral and histopathological changes, boosting the effectiveness, and implication of the sciatic function index as a mirror for changes occurring on the tissue level.ConclusionVitamin C is a promising therapeutic in the treatment of PNI. The sciatic function index (SFI) test is a reliable accurate method for assessing sciatic nerve integrity after both partial disruption and regrowth.

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“…The therapeutic effect of PBMT for treating or managing diseases and injuries has gained significant popularity among researchers and clinicians, especially for managing oral complications of cancer therapy, such as oral mucositis [6,7] or taste alterations [8,9]. In literature, red or near-infrared (NIR) light with 600 to 1,000 nm wavelength has shown beneficial effects to neuronal growth [10,11] and support nerve regeneration [12,13]. One of the effects of PBMT using NIR is related to the chromophore cytochrome C oxidase (COX) containing both heme and copper centers and absorbs light into the NIR region, which affects the creation of adenosine triphosphate (ATP).…”

Section: Introductionmentioning

confidence: 99%

Effect of 850 nm photobiomodulation on the adenosine diphosphate/adenosine triphosphate measure of apoptosis in geniculate ganglion neuronal cells in vitro

Kim,

Lee,

Abueva

et al. 2023

Medical Lasers

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Background: Photobiomodulation therapy (PBMT) is a non-invasive treatment that uses low-level light therapy to stimulate the cellular function and promote tissue healing. The geniculate ganglion is a complex network of nerve fibers that plays a vital role in the sensory processing of the head and face, including taste perception. A dysfunction of geniculate ganglion cells can result in taste disorders and other conditions, such as facial nerve palsy and tinnitus.Methods: This in vitro study examined the effects of PBMT on geniculate ganglion cells. Geniculate ganglion neuronal cells (GGNs) were cultured and exposed to different parameters of PBMT. The cell viability, proliferation, and adenosine diphosphate/adenosine triphosphate (ADP/ATP) levels were assessed.Results: PBMT at 10 J increased the cell viability three and seven days after PBMT via an MTT assay. The ADP/ATP assay results showed a significant difference in the ADP/ATP ratio of PBM-treated cells to the control group the days after PBM treatment. PBMT at doses of 1 and 5 J showed a significant increase in the ADP/ATP ratio compared with the control group, while the 10 J group exhibited a marked difference relative to other groups. Conclusion:The PBM treatment of 10 J improved the cell viability significantly in the GGNs and prevented apoptosis. Therefore, PBMT may be a safe and non-invasive approach for treating the geniculate ganglion, potentially addressing taste dysfunction. The study provides valuable insights into the potential therapeutic applications of PBMT at an appropriate energy level for taste or neurological diseases involving geniculate ganglion tissue.

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Photobiomodulation promotes neural regeneration when compared to simvastatin treatment in a sciatic nerve crush model

Cited by 6 publications

References 35 publications

Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review

Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review

Comparative neuroprotective effects of Cerebrolysin, dexamethasone, and ascorbic acid on sciatic nerve injury model: Behavioral and histopathological study

Effect of 850 nm photobiomodulation on the adenosine diphosphate/adenosine triphosphate measure of apoptosis in geniculate ganglion neuronal cells in vitro

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