2016
DOI: 10.1007/s10103-016-1904-0
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Photobiomodulation regulates cytokine release and new blood vessel formation during oral wound healing in rats

Abstract: The aim of the present study was to evaluate the effects of photobiomodulation (PBM) on cytokine levels and angiogenesis during oral wound healing. Ulcers were made on the dorsum of the tongue in 48 Wistar rats. Irradiation with an indium-gallium-aluminum-phosphide (InGaAlP) laser (660 nm; output power, 40 mW; spot size, 0.04 cm(2)) was performed once a day on two points of the ulcer for 14 days. Two different energy densities were used: 4 J/cm(2) (energy per point 0.16 J, total energy 0.32 J) and 20 J/cm(2) (… Show more

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Cited by 58 publications
(35 citation statements)
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“…Angiogenesis, that is, the formation of new blood vessels from pre-existing ones, is one of the mechanisms involved in tissue repair, specifically in the proliferative phase (3–7 postsurgical days) ( 14 ). It is responsible for supplying the oxygen and nutrients necessary to sustain cell metabolism at the wound area ( 15 , 16 ). Moreover, the stimulation of blood vessel formation has been associated with accelerated and improved tissue repair in experimental models in vivo ( 17 - 19 ).…”
Section: Introductionmentioning
confidence: 99%
“…Angiogenesis, that is, the formation of new blood vessels from pre-existing ones, is one of the mechanisms involved in tissue repair, specifically in the proliferative phase (3–7 postsurgical days) ( 14 ). It is responsible for supplying the oxygen and nutrients necessary to sustain cell metabolism at the wound area ( 15 , 16 ). Moreover, the stimulation of blood vessel formation has been associated with accelerated and improved tissue repair in experimental models in vivo ( 17 - 19 ).…”
Section: Introductionmentioning
confidence: 99%
“…For example, Chen [27] found that inhibiting the expression of IL-6 and IL-10 could reduce the in ammatory response to promote wound healing. The secretion of VEGF in the healing process also exerts and important effect, and VEGF will promote the proliferation of vascular endothelial cells and their survival, accelerating the formation of new blood vessels [28][29][30][31]. The blood vessels are the channels of nutrient delivery in the body [32], and ensure that the tissues and organs are provided with su cient requirements for new skin formation [33].…”
Section: Discussionmentioning
confidence: 99%
“…Low-power laser irradiation has been proposed as a treatment (lowlevel laser therapy; LLLT) to harness the stimulatory effect of light on living tissues. LLLT using a visible light laser with a wavelength of 400-700 nm reportedly promotes wound healing [9,10] and cell proliferation [11,12], relieves pain [13][14][15][16][17], and induces bone formation [18][19][20]. Several reports have indicated that LLLT is suitable for use in orthodontic treatment.…”
Section: Introductionmentioning
confidence: 99%