Photobiomodulation Therapy for Myofascial Pain in Temporomandibular Joint Dysfunction: A Double-Blinded Randomized Clinical Trial

Nadershah, Mohammed; Abdel-Alim, Hala M.; Bayoumi, Amr; Jan, Ahmed M; Elatrouni, Ali; Jadu, Fatima M.

doi:10.1007/s12663-019-01222-z

Cited by 18 publications

(39 citation statements)

References 12 publications

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“…The sample size (n) distribution amongst the included studies was as follows; n > 50 in 10 studies [58,64,65,69,82,[89][90][91]93,98], n = 40-50 in 15 studies [59,61,62,67,68,70,73,[83][84][85]87,88,92,95,99], n = 30-40 in 7 studies [72,73,75,78,81,95,98], n = 20-30 in 7 studies [57,58,76,77,80,87,97] and n = 10-20 in 5 studies [61,64,67,79,82].…”

Section: Sample Sizementioning

confidence: 99%

“…Amongst the included studies, gender distribution was noted as follows: more than a 50% female population in 27 studies [57][58][59]62,65,[67][68][69][70][71][73][74][75][78][79][80][81][82][83][84][85][86][87][88][89]91,97,98,100], an onlyfemale population in eight studies [61,72,76,77,90,93,95,99] and an approximately equal proportion of both males and female population in three studies [63,92,96]. Additionally, five studies failed to report any relevant information on gender distribution in their respective studies [60,64,66,78,84].…”

Section: Gender Distributionmentioning

confidence: 99%

“…The affected areas in the included studies were categorized as follows: TMJ in nine studies [57,59,60,63,65,70,88,96,99]; extraoral (EO) masticatory muscles in eight studies [66,68,76,78,80,81,83,97]; intraoral (IO) masticatory muscles in one study [95]; TMJ and masticatory muscles (EO) in 10 studies [69,[73][74][75]85,[90][91][92][93]98]; TMJ and masticatory muscles (EO and IO) in seven studies [11,16,21,28,33,38,44]; TMJ, masticatory muscles (EO) and cervical (neck muscles) in four studies [61,62,71,87]; TMJ, masticatory (EO and IO) and cervical muscles in four studies [58,64,79,82]; and masticatory (EO and IO) and cervical muscles in one study [86].…”

Section: Affected Areamentioning

confidence: 99%

“…In terms of allocation of symptoms/affected area at baseline, four out of 44 studies specified unilateral TMJ symptom presentation [65,67,72,92], whereas three studies specified bilateral TMJ involvement [58,76,77]. Interestingly, three studies reported inclusion of patients with either unilateral or bilateral TMJ involvement [57,88,100], which were as follows; in one study, five patients in each group (two groups with 15 patients in each, n = 30) presented with unilateral TMJ involvement, and the remaining 20 patients showed bilateral TMJ involvement [57]; in one study, seven patients (n = 44) presented with unilateral TMJ involvement and the rest of the patients showed bilateral TMJ involvement [88]; and in one study, 16 patients (n = 44) presented with unilateral TMJ involvement and the rest of the patients showed bilateral TMJ involvement [100].…”

Section: Affected Areamentioning

confidence: 99%

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Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials

Hanna

Dalvi²,

Bensadoun

et al. 2021

Antioxidants

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This systematic review and meta-analysis (PROSPERO registration; ref CRD 42020198921) aimed to govern photobiomodulation therapy (PBMT) efficacy in temporomandibular disorder (TMD). PRISMA guidelines and Cochrane Collaboration recommendations were followed. Differences in pain reduction assessment by qualitative measurement with visual analogue scale pain (VAS), pressure threshold (PPT) and maximum mouth opening (MMO) were calculated with 95% confidence intervals and pooled in a random effects model with a subgroup analysis, evaluating the role of follow-up duration. Heterogeneity was analysed using Q and I2 tests. Publication bias was assessed by visual examination of funnel plot symmetry. Qualitative analysis revealed 46% of the 44 included studies showed a high risk of bias. Meta-analysis on 32 out of 44 studies revealed statistically significant intergroup differences (SSID) for VAS (SMD = −0.55; 95% CI = −0.82 to −0.27; Z = 3.90 (p < 0.001)), PPT (SMD = −0.45; 95% CI = −0.89 to 0.00; Z = 1.97 (p = 0.05)) and MMO (SMD = −0.45; 95% CI = −0.89 to 0.00; Z = 1.97 (p = 0.05)), favouring PBMT compared to control treatment strategies. Sensitivity analysis revealed SSID (SMD = −0.53; 95% CI = −0.73 to −0.32; Z = 5.02 (p < 0.0001)) with low heterogeneity (T2 = 0.02; χ2 = 16.03 (p = 0.31); I2 = 13%). Hence, this review, for first time, proposed suggested recommendations for PBMT protocols and methodology for future extensive TMD research.

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Section: Sample Sizementioning

confidence: 99%

Section: Gender Distributionmentioning

confidence: 99%

Section: Affected Areamentioning

confidence: 99%

Section: Affected Areamentioning

confidence: 99%

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Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials

Hanna

Dalvi²,

Bensadoun

et al. 2021

Antioxidants

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“…The results of recent studies on the application of LLLT in the treatment of TMDs are still contradictory. Many studies have confirmed the effectiveness of low-level laser therapy in decreasing pain and improving the function of orofacial system in patients with TMDs [7][8][9][10][11][12]. On the other hand, the results of some placebo-controlled studies negate the positive effects of LLLT in reducing pain and improving function of orofacial system compared to placebo [13,14].…”

Section: Introductionmentioning

confidence: 99%

Low-level laser therapy effectiveness in patients with temporomandibular disorders

et al. 2021

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Introduction/Objective. Low-level laser therapy has been suggested as an alternative pain relief therapy in temporomandibular disorders patients. The aim of this study was to examine the effects of Low-level laser therapy on reducing pain intensity in temporomandibular disorders patients, compared to non-steroidal anti-inflammatory drugs. Methods. A total of 63 patients diagnosed with Research Diagnostic Criteria for Temporomandibular Disorders were divided into two groups. In the first group of 35 patients low-level laser therapy was applied three times a week, 15 treatment sessions during 5 weeks (Wavelength: 780 nm; Power density: 70 mW/cm2; Radiant energy: 4.2 J; Energy density: 4.2 J/cm2; Total treatment dose: 16.8 J/cm2;). The second group included 28 participants subjected to nonsteroidal anti-inflammatory drugs therapy (ibuprofen) during two weeks (first three days 3 ? 400 mg, remaining time 2 ? 400 mg per day). Pain was evaluated using 100 mm Visual Analog Scale, at the baseline, during therapy, two weeks and three months after treatments. Results. Statistically significant reduction of pain intensity was achieved both, in low-level laser therapy and in nonsteroidal anti-inflammatory drugs therapy groups and remained steady in the follow-up period of three months (p <0.01). Differences in Visual Analog Scale scores between observed groups were not statistically significant in each of the evaluation periods, (p = 0.375, p = 0.665, p = 0.52, respectively). Conclusion. The low-level laser therapy protocol applied in this research was efficient in reducing pain in temporomandibular disorders patients.

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Resistance exercise and low‐level laser therapy improves grip strength and morphological aspects in the ankle joint of Wistar rats with experimental arthritis

Retameiro¹,

Neves²,

Tavares³

et al. 2022

The Anatomical Record

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Rheumatoid arthritis (RA) is an inflammatory disease mainly affecting synovial joints. Photobiomodulation through low‐level laser therapy (LLLT) and resistance exercise may improve the inflammatory process. Therefore, we analyzed the effects of resistance exercise, LLLT, and the combination of both treatments on hind paw grip strength and ankle joint histomorphometric aspects of Wistar rats subjected to experimental RA. A total of 64 male Wistar rats were divided into eight groups: control, control LLLT, control exercise, control LLLT and exercise, arthritis, arthritis LLLT, arthritis exercise, and arthritis LLLT and exercise groups. The experimental RA was induced by a complete Freund's adjuvant injection into the knee joint cavity. Climbing exercises and LLLT (660 nm; 5 J/cm2 per point) were performed as the treatment. In addition, muscle strength was evaluated using the grip strength test, and morphometric evaluations were performed on the ankle joint. Generalized mixed models and multivariate analysis of variance tests were used for statistical analysis. Statistical significance was set at a p‐value of .05. Arthritis LLLT, exercise, and LLLT and exercise had positive effects on grip strength between the groups (F[7.56] = 5.8, p < .004) and within the groups (F[4.3] = 9.9, p < .002) throughout the evaluations. Morphometry revealed degenerative lesions in the ankle joint as subintima with angiogenesis, inflammatory cells, flocculated articular cartilage, chondrocyte disorganization, and pannus in the arthritis group (p < .001). The treated groups exhibited morphological characteristics similar to those of the control group. LLLT and resistance exercise restored muscle strength and morphological aspects of the ankle joint in rats with experimentally induced RA.

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Photobiomodulation Therapy for Myofascial Pain in Temporomandibular Joint Dysfunction: A Double-Blinded Randomized Clinical Trial

Cited by 18 publications

References 12 publications

Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials

Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials

Low-level laser therapy effectiveness in patients with temporomandibular disorders

Resistance exercise and low‐level laser therapy improves grip strength and morphological aspects in the ankle joint of Wistar rats with experimental arthritis

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