Photobiomodulation Therapy in the Treatment of Oral Mucositis—A Case Report

Jabłoński, Przemysław; Musiał, Mikołaj; Wiench, Rafał; Stefanik, Natalia; Olchowy, Cyprian; Matys, Jacek; Skaba, Dariusz; Grzech‐Leśniak, Kinga

doi:10.3390/medicina58050618

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…The treatment with a 635 nm laser diode was advised. The treatment provided total remission of mucositis on the 21st day of treatment, in which the lesion was healed, obtaining pink mucosa pain relief (Jabłoński et al, 2022). This is observed in the studies by Melo, M. C. F. (2020) andEl Mobadder, M. et al (2018), in which all these effects were evaluated.…”

Section: Mucositismentioning

confidence: 70%

“…It is suggested that the analgesic effects of PBM are achieved with wavelengths of 630-650 nm and 780-900 nm, the inflammatory effect is at the same wavelengths and the healing effect between 780-805 nm (Hamblin, Agrawal, & De Sousa, 2016, Jabłoński et al, 2022.…”

Section: Mucositismentioning

confidence: 99%

“…Although is no consensus in the literature about the parameters used in the resolution of oral mucositis, there seems to be an agreement that wavelengths in the 660 nm range have better results in the treatment of the disease (Hamblin, Agrawal, & De Sousa, 2016, Jabłoński et al, 2022.…”

Section: Mucositismentioning

confidence: 99%

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Photobiomodulation in the treatment of oral diseases

Luna

Guimarães²,

Silva³

et al. 2023

RSD

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The modern conception of dentistry is based on the search for noninvasive clinical applicability methods that improve the prognoses of dental pathologies and, therefore, the interest in light-tissue interaction technology has increased in the last decade. The present study aims to explore the applicability of photobiomodulation (PBM) in dentistry with emphasis on wavelengths provided to target tissues and the underlying mechanisms of action of lasers observed in the treatment of various oral diseases, as well as the affected processes that include, but are not limited to wound healing, tissue biostimulation, tissue and nerve regeneration, inhibition of pain and inflammatory processes. The effects obtained through photobiomodulation are correlated with the parameters involved, such as the equipment used, wavelength, power dosages, irradiation duration, energy density, general patient conditions, target tissue, pathology and etiologies considered. Depending on the conditions reported, the photobiomodulator effect or also known as low intensity laser therapy (LLLT) influences the increase of cellular metabolism through the application of photonic energy that presents monochromaticity and propagates consistently in time and space. Thus, the protocols for the application of the photonic properties of this therapeutic modality should be analyzed in the treatment of oral conditions and pathologies associated with glandular, neural, autoimmune, traumatic, and idiopathic diseases.

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Section: Mucositismentioning

confidence: 70%

Section: Mucositismentioning

confidence: 99%

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Photobiomodulation in the treatment of oral diseases

Luna

Guimarães²,

Silva³

et al. 2023

RSD

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“…Although the costs of the preventive protocol exceed the costs of OM treatment, other expenditures are associated with the occurrence of OM. The dissemination of PBM for the prevention and treatment of cancerrelated comorbidities can improve the patient's quality of life [31], reduce the need for nasogastric or parenteral nutrition [32], maintain the patient's body weight [33], shorter hospital stays [7,34] and, consequently, reduce hospital-related costs [18]. Further statistical models should simulate the cost-opportunity relationship of the administration of PBM in patients undergoing cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation for Oral Mucositis – A Microcosting and Budget Impact Analysis from a Brazilian Perspective

Bezerra,

Lima,

Moura

et al. 2024

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To measure the costs of preventive and therapeutic protocols of Photobiomodulation (PBM) for oral mucositis (OM) and their budgetary impact on Brazil's Ministry of Health (BMH). Material and Methods: A partial economic analysis was performed to estimate the costs using a bottom-up approach from a social perspective. Monetary values were assigned in Brazilian reais (BRL). The costs of the preventive protocol were calculated for five, 30, and 33 consecutive PBM sessions, depending on the antineoplastic treatment instituted. The costs of the therapeutic protocol were calculated for 5 or 10 sessions. The annual financial and budgetary impact was calculated considering the groups of oncologic patients with a higher risk of development of OM, such as those with head and neck and hematological cancer and pediatric patients. Results: The cost of a PBM session was estimated at BRL 23.75. The financial impact of providing one preventive protocol per year for all oncologic patients would be BRL 14,282,680.00, 0.030% of the estimated budget for hospital and outpatient care of the BMH in 2022. The financial and budgetary impacts of providing one treatment for OM for all patients in one year would be BRL 2,225,630.31 (0.005%, most optimistic scenario) and BRL 4,451,355.63 (0.009%, most pessimistic scenario). Conclusion: The budgetary impact of implementing PBM protocols in the Brazilian Healthcare System is small, even in a pessimistic scenario.

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“…Still, more often, three appointments per week or daily PBMT for the first 5 days and then every other day is recommended. 12 A review published in 2017 by Al-Maweri et al emphasized that PBMT is effective in the management of symptomatic OLP. However, another systematic review by Akram et al in 2018 that sought to assess the efficacy of PBMT in comparison to topical corticosteroids in the therapy of atrophic-erosive types of OLP concluded that it remains debatable whether PBMT is more effective than topical corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation Therapy in the Management of Oral Lichen Planus: A Systematic Review and Meta-Analysis

Soh,

Cheah,

Veettil

et al. 2024

Eur J Dent

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Photobiomodulation therapy (PBMT) is a non-invasive and the latest form of therapy used in the treatment of non oncological diseases as well as cancers of various types and locations. The aim of this study was to systematically review and assess the efficacy of PBMT in managing oral lichen planus (OLP) compared to the interventions. A systematic review and meta-analysis were implemented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. An electronic search using PubMed, Scopus, and Cochrane was conducted to retrieve relevant studies published until June 2023. The outcomes evaluated included the reduction in pain score and clinical severity scores (Prospero No CRD42023428626). A total of eight studies were identified for qualitative synthesis. The pooled analysis incorporating six studies revealed that there are no significant differences for both mean pain score (mean difference [MD] = 0.21, 95% confidence interval [CI] = −0.51, 0.93) as well as clinical score (MD = −0.08, 95% CI = −0.4, 0.25) between PBMT and comparison groups. Subgroup analysis based on corticosteroids as controls showed that there was no significant difference in mean reduction in pain score between PBMT and topical steroids (MD = 0.38, 95% CI = −0.54, 1.31). PBMT is as effective as other interventions in the treatment of OLP, though not superior, and can be a promising alternative treatment for cases resistant to steroids or when steroids are contraindicated. Further studies are recommended to standardize the optimal settings for the treatment of OLP.

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Photobiomodulation Therapy in the Treatment of Oral Mucositis—A Case Report

Cited by 7 publications

References 27 publications

Photobiomodulation in the treatment of oral diseases

Photobiomodulation in the treatment of oral diseases

Photobiomodulation for Oral Mucositis – A Microcosting and Budget Impact Analysis from a Brazilian Perspective

Photobiomodulation Therapy in the Management of Oral Lichen Planus: A Systematic Review and Meta-Analysis

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