Photocatalysis in the Life Science Industry

Abstract

In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science industry require access to mild and robust synthetic methodologies to systematically modify chemical structures, explore novel chemical space, and enable efficient synthesis. In this context, photocatalysis has emerged as a powerful technology for the synthesis of complex and often highly functionalized molecules. This Review aims to summarize the published contributions to the field from the life science industry, including research from industrial-academic partnerships. An overview of the synthetic methodologies developed and strategic applications in chemical synthesis, including peptide functionalization, isotope labeling, and both DNA-encoded and traditional library synthesis, is provided, along with a summary of the state-of-the-art in photoreactor technology and the effective upscaling of photocatalytic reactions.

A New Entry to Purely Organic Thermally Activated Delayed Fluorescence Emitters Based on Pyrido[2,3‐b]pyrazine‐Dihydrophenazasilines Donor‐Acceptor Dyad

“…The synthetic routes to 1-3 are shown in Scheme 1. The 7bromo-2,3-diphenylpyrido[2,3-b]pyrazine (4) and 10-bromoacenaphtho[1,2-b]pyrido[2,3-e]pyrazine (6) were easily prepared through the condensation between 2,3-diamino-5-bromopyradine with benzil and phenanthrene-9,10-dione, respectively, according to the procedures in literature. [21,22] DÀ A compounds 1-3 were synthesized in good yields through the Pd-catalyzed Buchwald-Hartwig amination of 4/6 with the corresponding DHPAzSi derivative (Scheme 1, and the detailed procedures and the spectroscopic data of the products are described in the Supporting Information).…”

“…[1,2] In addition to OLEDs, the high capability of harvesting triplet excited states allows for diverse applications of TADF-active organic compounds, spanning from time-resolved bioimaging [3][4][5] to organic photoredox catalysis. [6] Therefore, the development of new TADF organic compounds and investigation of their photophysical properties contributes to the further understanding of underlying principles and the advancement of materials science.…”

Exploring metallic and plastic 3D printed photochemical reactors for customizing chemical synthesis

“…Significant progress in this area may be achieved by the design and manufacturing of customized equipment by additive manufacturing (3D printing) 49 , 50 . The area of 3D printing has experienced tremendous growth, and it has already been widely incorporated in different fields of science and technology 51 , 52 .…”

Development of a high intensity parallel photoreactor for high throughput screening

“…12 This emerging power of photoredox catalysis is already showing significant potential for industrial application, particularly in the pharmaceutical industry both in process and in discovery chemistry. [13][14][15] However, the increasing mechanistic complexity in photoredox transformations has also created challenges in optimizing these new methods and extending their scope to access diversity in complex molecule settings. Taking metallaphotoredox catalytic sp 2 -sp 3 decarboxylative C-C coupling as an example (Scheme 1), the accepted mechanistic model involves two interlocking catalytic cycles.…”