Photocatalytic degradation of ciprofloxacin pollutant and in-vitro cytotoxic activity of gold nanoparticles using seed extract of Abrus precatorius

Abstract

Synthesis of nanoparticles from plant extract is a very simple reliable, rapid, affordable and un-hazardous technique. In the present exploration, gold nanoparticles (Au NPs) were rapidly synthesized using seed extract of Abrus precatorius. The prepared nanomaterials were systematically proved by FTIR, UV-Visible, Powder-XRD, SEM, EDAX and TEM analyses. The formation of Au NPs was primarily identified by the colour change from yellow to purple within 5 min and which showed a surface Plasmon peak around 535 nm. The dimension of the gold nanoparticles was found to be in the range of 10-20 nm. The particles were poly-dispersed with a triangular, spherical and hexagonal shape. The gold nanoparticles were used to degrade the antibiotic drug ciprofloxacin (CIP) with an efficiency of above 95%. Moreover, the bio-synthesized gold nanoparticles had been assessed for their in-vitro cytotoxic activity on human breast cancer cells (MCF-7) lines. The colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used to evaluate the Inhibitory Concentration (IC 50 ) value. The IC 50 value is 37 ± 1.5 lg/mL. In future, this can be used for breast cancer therapy.

Exploring the antioxidant potential of a notorious weed using a microwave-based transformation to gold nanoparticles: The case of Mikania micrantha

“…It is the primary proof of the morphology structure of MMAuNPs. The presence of primarily spherical morphology structures has confirmed the anisotropic nature and morphological structure of AuNPs [55]. The particle size of MMAuNPs was 80-105 nm, which in contrast is relatively smaller than that determined by DLS approaches.…”