Photocatalytic Degradation of Metoprolol Tartrate

Moctezuma, Edgar; Leyva, Elisa; López, Mariana; Pinedo, A. Torres de; Zermeño, Brenda; Serrano, Benito

doi:10.1007/s11244-013-0119-x

Cited by 25 publications

(15 citation statements)

References 26 publications

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“…As previously reported(Moctezuma et al 2013), the intensity of the primary band of the aromatic ring decreases with time indicating the destruction of this part of the metoprolol molecule. At the beginning of the experiment, the intensity of the secondary band of the aromatic ring located at 274 nm and the intensity of the band of the nonbonding electrons of the aryl ether located at 282 nm increased drastically with time indicating the insertion of HO• radicals in the aromatic ring and the cleavage or hydroxylation of the amine and the methoxyl lateral chains.…”

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confidence: 86%

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Photocatalytic Decomposition of Metoprolol and Its Intermediate Organic Reaction Products: Kinetics and Degradation Pathway

Pinedo

López

Leyva

et al. 2016

International Journal of Chemical Reactor Engineering

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High purity metoprolol prepared by neutralization of an aqueous solution of metoprolol tartrate is efficiently mineralized to CO 2 and water by photocatalysis with TiO 2 , UV light and a constant flow rate of oxygen. Since the tartrate anions were eliminated, all the HO• generated by photocatalysis reacted efficiently with the aromatic part of the medication. The reaction pathway includes two routes of degradation. The first one includes the transformation of metoprolol to hydroquinone via formation of 4-(2-methoxyethyl)phenol, 2-(4-hydroxyphenyl)ethanol and 4-hydroxybenzaldehyde. Metoprolol is also degraded directly to hydroquinone. Then, this aromatic compound is oxidized to 1,2,4-benzenetriol, which is rapidly oxidized to low molecular weight organic acids before being completely mineralized to CO 2 and water. Kinetic studies indicated that the initial reaction rate of the degradation of metoprolol, 4-(2-methoxyethyl)phenol, 2-(4-hydroxyphenyl)ethanol and 4-hydroxybenzaldehyde is described by the LH-HW model.

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confidence: 86%

“…Moctezuma et al 2013); there are some important differences due to the absence of the tartrate anion. The protons (1-H and 2-H) of the identical methyl groups on the metoprolol molecule are integrated into a doublet of doublet at δ 0.76-0.77 and 0.78-0.79 ppm.…”

mentioning

confidence: 99%

Photocatalytic Decomposition of Metoprolol and Its Intermediate Organic Reaction Products: Kinetics and Degradation Pathway

Pinedo

López

Leyva

et al. 2016

International Journal of Chemical Reactor Engineering

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“…Among these treatments, advanced oxidation processes (AOPs) stand out, where the use of oxidizing agents such as hydrogen peroxide, ozone, and chlorine promotes the degradation of various water pollutants through the generation of radical species such as˙HO and O 2˙− . One method to produce these oxidant radicals is photocatalytic processes, which have already been used by other authors for the degradation of ECs; [12][13][14] the best known catalyst is homogeneous phase TiO 2 , the main disadvantage of which is its activation in the ultraviolet region. In the same way, one of the most studied chemical processes presenting high removal rates of organic compounds in aqueous media is the Fenton-like process, which promotes the production of hydroxyl radicals (˙HO) generated from the reaction of hydrogen peroxide (H 2 O 2 ) and iron(III) salts.…”

Section: Introductionmentioning

confidence: 99%

Photodegradation of antihistamine chlorpheniramine using a novel iron-incorporated carbon material and solar radiation

Mar-Ortiz

Salazar-Rábago

Sánchez‐Polo

et al. 2020

Environ. Sci.: Water Res. Technol.

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“…The half-life of this compound is 3-4 hours and it has a pk a = 9.5 (26,27). MTP has a positive charge at neutral pH and is a moderate hydrophilic substance (28,29). This drug increases its mobility in the presence of anionic surfactant (30).…”

Section: Introductionmentioning

confidence: 99%

Removal of metoprolol from aqueous solutions by the activated carbon prepared from pine cones

Naghipour

Amouei

Ghasemi

et al. 2019

Environ Health Eng Manag

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Background: Metoprolol (MTP) with its low biodegradability is one of the most dominant micropollutant in the effluent of wastewater treatment plants. The aim of this study was to investigate the removal of metoprolol from aqueous solutions by the activated carbon prepared from pine cones. Methods: The pine cones were activated using thermal activation method. Characteristics of the adsorbent were determined using Brunauer-Emmett-Teller (BET) and scanning electron microscopy (SEM). In this study, the influent of different parameters such as pH, contact time, initial concentrations of metoprolol, adsorbent dose, temperature, adsorption isotherms, and kinetics were investigated. Results: The maximum removal efficiency of MTP (89.2%) was obtained at pH=8.5, adsorbent dose=1.5 g, contact time=60 min, and initial concentration=50 mg/L. By increasing the adsorbent dose, the removal efficiency also increased, but the adsorption capacity decreased, however, by increasing the initial concentration, the removal efficiency decreased, but the adsorption capacity increased. The isotherm experimental data for metoprolol was best fitted using the Langmuir model, and kinetic data were better described by pseudo-second-order kinetic model. The thermodynamic study indicated that the adsorption of MTP by the adsorbent was feasible, spontaneous, and endothermic. Conclusion: MTP removal by the activated carbon prepared from pine cones showed that this natural adsorbent is appropriate for removal of metoprolol from aqueous solutions regarding cost, efficiency, and production method.

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Photocatalytic Degradation of Metoprolol Tartrate

Cited by 25 publications

References 26 publications

Photocatalytic Decomposition of Metoprolol and Its Intermediate Organic Reaction Products: Kinetics and Degradation Pathway

Photocatalytic Decomposition of Metoprolol and Its Intermediate Organic Reaction Products: Kinetics and Degradation Pathway

Photodegradation of antihistamine chlorpheniramine using a novel iron-incorporated carbon material and solar radiation

Removal of metoprolol from aqueous solutions by the activated carbon prepared from pine cones

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