Photocatalytic redox-neutral reaction of γ-indolyl α-keto esters

Abstract

The direct γ-C(sp3)-H activation of saturated α-keto esters has long been an elusive transformation. We found that photo-redox catalysis IrIII in combination with DABCO as dual hydrogen-bonding donor and organic...

Py-2NO ligand enabled Ni(ii)-catalyzed asymmetric Michael addition reaction of indoles with β,γ-unsaturated α-keto esters

“…The absolute configuration of 8a was assigned to be R based on a previous report. 11 Based on the same plausible mechanism analysis, the stereochemistry of the other products 8 was assigned by analogy.…”

“…10 However, due to the high reactivity of indoles 6 and β,γ-unsaturated α-ketoesters 7 , low reaction temperatures were generally applied to ensure high stereoselectivity of the reactions. 11 It is desirable to develop new and effective asymmetric synthetic protocols, which can be easily handled and operated under mild conditions.…”