Photocatalytic Synthesis of unsymmetrical Bis-N-Heterocycles

Abstract

In this study, a sustainable approach has been revealed for the synthesis of bis-N-heteroaryl motifs comprising an indole and an isoquinoline/quinoline moieties. A novel photolabile phthalimide reagent based on indole was specifically designed to facilitate its coupling with medicinally valuable quinoline and isoquinoline motifs in the Minisci-type reaction. Indomethacin and ibuprofen-based reagents were also coupled with isoquinolines to generate a unique chemical space for further exploration in drug discovery research. Detailed experimental and theoretical studies were conducted to understand the mechanism of the developed protocol. This protocol can be a green tool for integrating drug molecules to discover new therapeutic leads.