Photochemical and photobiological properties of furocoumarins and homologues drugs

Bordin, F.

doi:10.1155/s1110662x9900001x

Cited by 19 publications

(3 citation statements)

References 19 publications

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“…Ferulic acid and byakangelicin from A. dahurica inhibited Cladosporium herbarum growth, while (R)-heraclenol showed potent antibacterial activity against Bacillus subtilis [24]. These furocoumarins induce toxicity, mainly by causing abnormal DNA-protein interactions, or DNA inter-strand interactions [28]. The resistance of some microbes to these furocoumarins may be due to the presence of feruloyl catabolising enzymes [29].…”

Section: Angelica Speciesmentioning

confidence: 99%

Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review

Tan¹,

Vanitha

2004

CMC

348

168

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The current practice of ingesting phytochemicals to support the immune system or to fight infections is based on centuries-old tradition. We review reports on seven Chinese herbs, (Aloe vera Mill. (Aloaceae), Angelica species (Umbelliferae), Astragalus membranaceus Bunge. (Leguminosae), Ganoderma lucidum (Fr.) Karst. (Ganodermataceae), Panax ginseng C.A Mey. (Araliaceae), Scutellaria species (Lamiaceae) and Zingiber officinale Rosc. (Zingiberaceae) with emphasis to their immunomodulatory and antimicrobial activities. While some of these herbaceous plants have a direct inhibitory effect on microbial organisms, we observe that each plant has at least one compound that selectively modulates cells of the immune system. The successful derivation of pure bioactive compounds from Ganoderma lucidum, ginseng and Zingiber officinale supports the traditional practice of using these plants to stimulate the immune system. As many modern drugs are often patterned after phytochemicals, studying the influence of each compound on immune cells as well as microbes can provide useful insights to the development of potentially useful new pharmacological agents.

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Section: Angelica Speciesmentioning

confidence: 99%

Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review

Tan¹,

Vanitha

2004

CMC

348

168

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“…And, furanocoumarin-induced hepatotoxicity has been reported to occasionally occur in humans [7]. It was once believed that FCs could interact with proteins, lipids in membranes, Separations 2023, 10, 508 2 of 14 ribosomes, mitochondria, and, in particular, mono-and diadducts with DNA or RNA, which are the main contributors to toxicity in humans and animals [8][9][10]. In addition, certain FCs have been publicized to act as greatly potent inhibitors of a quantity of cytochromes P450 mono oxygenases [11], which can be interpreted as hepatotoxicity.…”

Section: Introductionmentioning

confidence: 99%

The Simultaneous Determination of Nine Furocoumarins in Angelica dahurica Using UPLC Combined with the QAMS Approach and Novel Health Risk Assessment Based on the Toxic Equivalency Factor

Wang,

Zan,

et al. 2023

Separations

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Objective: This study aimed to provide data for the type and content of linear furocoumarins (FCs) in Angelica dahurica (AD) in order to assess their cumulative risks and provide a scientific basis for the rational use and quality evaluation of the medicinal AD to improve public health. Methods: A UPLC method was developed for the simultaneous determination of nine FCs initially by using imperatorin (Im) as the internal standard substance, including Im, phellopterin (Ph), isoimperatorin (Is), oxypeucedanin hydrate (Oh), byakangelicin (Bn), xanthotoxin (8-MOP), bergapten (5-MOP), byakangelicol (Bl), and oxypeucedanin (Op) in two species of Angelica dahurica (AD). And, the risk assessment for the total FCs in AD was explored using the hazard index combined with the toxic equivalency factor (TEF-HI) strategy for the first time. Results: The established method revealed acceptable applicability, and there were no significant differences compared with the external standard method (ESM). The quantitative results demonstrated that the total content of FCs in Angelica dahurica (BZ) were higher than that in Angelica dahurica var. formosana (HBZ), and there was a great difference between the Bl and Op. Moreover, the risk assessment data revealed that the risk of total FCs in AD to human health was low. Conclusions: The established UPLC method that determined nine FCs in AD using a single marker could solve the problem of difficulty in obtaining a chemical reference substance with high purity and requiring a long determination time. And, the TEF-HI risk assessment approach associated with FCs in ADs could guide the rational utilization of toxic FCs in ADs in the progress of improving public health safety. In short, the whole systematic strategy provides a scientific basis for rational quality evaluation and the healthy use of related herbal medicines.

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“…Psoralen has a greater tendency to form di-adducts than the methoxy analogues bergapten and xanthotoxin. Angelicin does not have a strong tendency to form di-adducts because of stearic hindrance (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

An LC/MS/MS Method for the Analysis of Furocoumarins in Citrus Oil

Hiserodt

Chen

2012

ACS Symposium Series

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Furocoumarins are secondary plant metabolites commonly found in the families Umbelliferae and Rutaceae. The basic members of this class of compounds are psoralen and angelicin. Researchers have shown particular interest in alkoxy analogues of psoralen; particularly at the 5-and 8-positions. Bergapten (5-methoxypsoralen) and xanthotoxin (8-methoxypsoralen) have been found to be effective in the treatment of the skin diseases psoriasis and vitiligo when combined with the phototherapy technique, PUVA. A mode of action is thought to be mono-adduct formation with DNA but formation of di-adducts, leading to cross-linked DNA and potential carcinogenic side effects, is also a possibility. In response to this, the International Fragrance Association (IFRA) and the European Commission have agreed to ban the use of furocoumarins in cosmetic products except when they are part of natural essences. When present as the result of natural essences, the total furocoumarin concentration cannot exceed 5 ppm based on the analysis of seven marker furocoumarins. To ensure compliance, an LC/MS/MS method using electrospray ionization was developed for the analysis of the seven marker furocoumarins plus seven other furocoumarins. Various aspects of method development are discussed as well as conclusions from the analysis of citrus oils.

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Photochemical and photobiological properties of furocoumarins and homologues drugs

Cited by 19 publications

References 19 publications

Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review

Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review

The Simultaneous Determination of Nine Furocoumarins in Angelica dahurica Using UPLC Combined with the QAMS Approach and Novel Health Risk Assessment Based on the Toxic Equivalency Factor

An LC/MS/MS Method for the Analysis of Furocoumarins in Citrus Oil

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