Photochemical and thermal retinal damage thresholds from an extended (413 nm) krypton laser source

Tata, Darrell B.; Stolarski, David J.; Schuster, Kurt J.; Imholte, Michelle L.; Hodnett, Harvey M.; Frakes, James W.; Carothers, Val; Rockwell, Benjamin A.

doi:10.2351/1.5056608

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Following these criteria, 43 threshold data have been excluded (from 10 studies): [10,19,57,64,65,66,67,68,69,70] and 253 threshold data published in 31 studies are found applicable to model validation: [10,11,18,19,32,33,53,54,56,57,58,59,60,61,70,71,72,73,74,55,75,76,77,78,79,80,81,82,83,84,85].…”

Section: Experimental Datamentioning

confidence: 99%

Validation of a computer model to predict laser induced thermal injury thresholds of the retina

Jean¹,

Schulmeister²

2013

International Laser Safety Conference

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We present a computer model for predicting the median dose (ED 50) that produces an ophthamoscopically detectable lesion in the retina. It consists of an optical model (beam propagation through the eye), a reflectance model (absorption distribution within the retinal tissues), a thermal model (solving the heat equation) and a damage model (based on the Arrhenius equation). The model was validated with 253 experimental ED 50 s that cover the entire thermal regime in both macular and paramacular regions encompassing wavelengths between 413 nm and 1338 nm, pulse durations between 100 μs and 3000 s and retinal spot sizes ranging from minimum to 2 mm. These ED 50 s are matched with a mean ratio of 0.93 and a standard deviation of 31 %. The largest ratio between model prediction and experimental data was 1.7. The applicability for using the model results for risk analysis for human exposure is discussed.

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