Photochemical fragmentation of phototoxic 2-arylquinolinemethanols

Approaches to a photocleavable protecting group for alcohols

“…14 It is noted that previous studies reported successful synthetic pathways to quinoline methanols (compound 2, Scheme 1). 15,16 A family of compounds was prepared to test whether photocleavage of this group would proceed with ultraviolet light (350 nm) in good yields. The alcohols examined included one compound (4e), which would likely be destroyed under strong oxidizing or reducing conditions.…”