Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study

Liu, Yancheng; Zhang, Peng; Li, Haixia; Tang, Ruizhi; Cui, Rong; Wang, Wenfeng

doi:10.1016/j.jphotobiol.2012.11.002

Cited by 6 publications

(7 citation statements)

References 46 publications

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“…When the molecule is excited, it will transition from the ground state to the excited state, generating a high concentration of short-lived excited states as well as intermediates generated during the decay process. 45,48 The instrument used in this study was a homemade instrument using a crystal laser (J1 K1 Laser System 2000 Neodymium/YAG) as the laser source. The system delivered 355 nm pulses of 5 ns duration with relatively low energy per pulse (<8 mJ).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Effects of Nanobubbles on Photochemical Processes of Levofloxacin Photosensitizer

Zhang,

Yuan,

Zheng

et al. 2024

Langmuir

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Photodynamic therapy (PDT) stands as an efficacious modality for the treatment of cancer and various diseases, in which optimization of the electron transfer and augmentation of the production of lethal reactive oxygen species (ROS) represent pivotal challenges to enhance its therapeutic efficacy. Empirical investigations have established that the spontaneous initiation of redox reactions associated with electron transfer is feasible and is located in the gas−liquid interfaces. Meanwhile, nanobubbles (NBs) are emerging as entities capable of furnishing a plethora of such interfaces, attributed to their stability and large surface/ volume ratio in bulk water. Thus, NBs provide a chance to expedite the electron-transfer kinetics within the context of PDT in an ambient environment. In this paper, we present a pioneering exploration into the impact of nitrogen nanobubbles (N 2 −NBs) on the electron transfer of the photosensitizer levofloxacin (LEV). Transient absorption spectra and time-resolved decay spectra, as determined through laser flash photolysis, unequivocally reveal that N 2 −NBs exhibit a mitigating effect on the decay of the LEV excitation triplet state, thereby facilitating subsequent processes. Of paramount significance is the observation that the presence of N 2 −NBs markedly accelerates the electron transfer of LEV, albeit with a marginal inhibitory influence on its energy-transfer reaction. This observation is corroborated through absorbance measurements and offers compelling evidence substantiating the role of NBs in expediting electron transfer within the ambit of PDT. The mechanism elucidated herein sheds light on how N 2 −NBs intricately influence both electron-transfer and energy-transfer reactions in the photosensitizer LEV. These findings not only contribute to a nuanced understanding of the underlying processes but also furnish novel insights that may inform the application of NBs in the realm of photodynamic therapy.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Effects of Nanobubbles on Photochemical Processes of Levofloxacin Photosensitizer

Zhang,

Yuan,

Zheng

et al. 2024

Langmuir

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“…The pH affects the speciation of OFL and ClO 2 . OFL can exist in three forms: OFLH þ , OFL, and OFL À (Equation ( 3)) (Liu et al 2013). With the increase of pH, the proportion of OFL À increased, and compared with OFLH þ and OFL, OFL À is more likely to react with ClO 2 .…”

Section: Phmentioning

confidence: 99%

The transformation mechanism of ofloxacin (OFL) by chlorine dioxide disinfection in water distribution system: kinetics, byproducts and toxicity

Chen

et al. 2022

Water Supply

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There is a research gap on the transformation of ofloxacin (OFL) in water supply system under the action of ClO2. The degradation kinetics of OFL under different ClO2 concentration, pH and pipe materials, and intermediates formation, as well as the toxicity of water in water supply system were first studied. The results shown that the degradation of OFL in PE pipe and deionized water increased with the increase of ClO2 concentration, and the reaction of OFL followed second-order kinetic model. The removal rate of OFL in deionized water was faster than that in PE pipe. The degradation rate of OFL in PE tube and deionized water were positively correlated with pH. In addition, degradation efficiency of OFL in different pipes followed: cast iron pipe > stainless steel pipe > PE Pipe. The detection of OFL intermediates shown that the crack of piperazine group were the main and initial products in the degradation process of OFL. In addition, the decarboxylation intermediates of quinolone group were also detected. The aquatic toxicity test showed that the degradation of OFL by ClO2 would increase the toxicity of water, therefore, the decrease of OFL may does not mean the decrease of water toxicity.

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“…The above mechanism can be expressed as 3 GEFX * + TMPD → GEFX •-+ TMPD •+ (2) The decay curve at 510 nm revealed that quenching of 3 GEFX * corresponds to a pseudo-first order reaction and that the rate constant k 2 between 3 GEFX * and TMPD has been evaluated to be 2.0 × 10 7 dm 3 mol −1 s −1 . To confirm the presence of dGMP •+ in the reaction between 3 GEFX * and dGMP, we designed a competing reaction containing GEFX, TMPD, and dGMP following a previously reported method [23,34] with modifications. The system was designed to ensure that 3 GEFX * mainly reacts with dGMP and that the reaction between 3 GEFX * and TMPD is negligible.…”

Section: Electron Transfer Between 3 Gefx * and Dgmpmentioning

confidence: 99%

“…The reaction is shown by the following equations: 3 GEFX * + TrpH → GEFX •-+ TrpH •+ (6) TrpH •+ → Trp • + H + (7) As shown in the inset of Fig. 6, the rate constant for the reaction of TrpH with 3 GEFX * was determined from the slope of the linear plot of the pseudo-first-order rate constant for the decay of 3 GEFX * at 510 nm against TrpH concentration to be 2.2 × 10 7 dm 3 mol −1 s −1 , which was also less than the rate (8.8 × 10 7 dm 3 mol −1 s −1 ) of the reaction between 3 PAX * (the triplet state of pazufloxacin) and TrpH [23]. This proved that the phototoxicity of GEFX less than PAX.…”

Section: Electron Transfer Between 3 Gefx * and Trphmentioning

confidence: 99%

“…The photochemical and phototoxic properties of some FQs, including rufloxacin [21], gatifloxacin [22], pazufloxacin [23], balofloxacin [24] and enoxacin [25], have been studied using time-resolved and steady-state techniques. However, details of the transient absorption spectra and kinetics of GEFX excited states formed during the photoreactions are still lacking, and to the best of our knowledge, no transient study has yet investigated the photochemical properties and photodamage of GEFX to DNA and proteins.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Photochemical properties of gemifloxacin: A laser flash photolysis study

Yan

Liu

Zhao

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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Photochemical properties and phototoxicity of Pazufloxacin: A stable and transient study

Cited by 6 publications

References 46 publications

Effects of Nanobubbles on Photochemical Processes of Levofloxacin Photosensitizer

Effects of Nanobubbles on Photochemical Processes of Levofloxacin Photosensitizer

The transformation mechanism of ofloxacin (OFL) by chlorine dioxide disinfection in water distribution system: kinetics, byproducts and toxicity

Photochemical properties of gemifloxacin: A laser flash photolysis study

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