Photochemical Reaction of Nalidixic Acid in Methanol

Park, Hyoung-Ryun; Park, Ok-Hyun; Lee, Hong-Yune; Seo, Jung-Ja; Bark, Ki‐Min

doi:10.5012/bkcs.2003.24.11.1618

Cited by 12 publications

(1 citation statement)

References 10 publications

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“…These photoexcitations can impair essential physiological signaling pathways, inducing cell death and apoptosis. It happens due to lesions in the genetic material leading to mutagenesis [22][23][24][25]. The wavelengths related to maximum light absorption can be determined by localizing the peaks in the absorption-spectrum.…”

Section: Theorymentioning

confidence: 99%

Effects of UV-, Visible-, Near-Infrared Beams in Three Therapy Resistance Case Studies of Fungal Skin infections

Penjweini¹,

Mokmeli²,

Becker³

et al. 2013

OPJ

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Fungal and bacterial diseases, directly infecting various parts of body, have received much attention in recent years. Bacterial infections, such as Tinea Pedis, Pityriasis versicolor and Mycetoma can secondarily occur in superficial fungal damaged skin. They often occur in immune compromised individuals including diabetics and patients with peripheral arterial diseases. Mycetoma infections can travel through the bloodstream affecting different organs. In this paper, we investigate the photo-inactivation of the pathogens causing Tinea Pedis, Pityriasis versicolor, and Mycetoma infections in three therapy resistant patients without photosensitizing drugs. We have used a combination of visible to near-infrared (VIS/NIR) laser beams in association with blue (B), red (R) and ultraviolet (UV) light emitted diodes (LEDs) with incident doses of 0.63-21.43 J/cm 2. These beams have minimum side effects on the normal part of the skin. According to the physicians' assessments, all case study patients achieved an observable progress such as decreases in inflammatory lesions, rapid process of wound healing and scars improvements. Side effects such as inflammation, crusting, or hypopigmentation were not observed. The presented irradiation protocol may be a valuable complementary treatment for patients suffering from fungal and bacterial skin infections.

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Section: Theorymentioning

confidence: 99%

Effects of UV-, Visible-, Near-Infrared Beams in Three Therapy Resistance Case Studies of Fungal Skin infections

Penjweini¹,

Mokmeli²,

Becker³

et al. 2013

OPJ

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show abstract

References

2007

Chemistry of Heterocyclic Compounds: A Series of Monographs

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Photoinduced decarboxylation of 9‐oxo‐6,9‐dihydro[1,2,5]selenadiazolo[3,4‐f]quinoline‐8‐carboxylic acid

Staško

Bella

Rimarčík

et al. 2011

J of Physical Organic Chem

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Photoinduced reactions of 9‐oxo‐6,9‐dihydro[1,2,5]selenadiazolo[3,4‐f]quinoline‐8‐carboxylic acid (SeQCA) were investigated in alkaline media (aqueous NaOH solutions) by electron paramagnetic resonance (EPR) spectroscopy, following the in situ formation of paramagnetic species. According to UV–Vis and nuclear magnetic resonance investigations, protonation (pH ≈ 11) and deprotonation (pH ≈ 13) of the imino hydrogen of the 4‐pyridone moiety has to be considered, reflected also in the different EPR spectra observed upon irradiation. Photoinduced generation of radicals was found only for carboxylate substituted SeQCA; other studied selenadiazoloquinolone derivatives, together with those substituted at the C(8) position (R = H, COOCH2CH3, COOCH3, COCH3 or CN), did not generate paramagnetic species during exposure. Consequently, photodecarboxylation was suggested as the decisive step, accompanied by the decomposition of the selenadiazole ring, resulting in the formation of ortho‐hydroxylate anions. EPR parameters elucidated from experimental EPR spectra obtained at pH ≈ 11 and pH ≈ 13 indicate the formation of oxygen‐centered radicals at the decarboxylated 4‐pyridone ring. EPR spin trapping experiments with nitromethane confirmed a very effective photoinduced electron transfer from all the selenadiazoloquinolones investigated. Copyright © 2011 John Wiley & Sons, Ltd.

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Photochemical Reaction of Nalidixic Acid in Methanol

Cited by 12 publications

References 10 publications

Effects of UV-, Visible-, Near-Infrared Beams in Three Therapy Resistance Case Studies of Fungal Skin infections

Effects of UV-, Visible-, Near-Infrared Beams in Three Therapy Resistance Case Studies of Fungal Skin infections

References

Photoinduced decarboxylation of 9‐oxo‐6,9‐dihydro[1,2,5]selenadiazolo[3,4‐f]quinoline‐8‐carboxylic acid

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