Photochemical Synthesis

Visible photons as ideal reagents for the activation of coloured organic compounds

“…come on, he predicted exactly that photochemistry would acquire a predominant role in organic synthesis! [1][2][3][4][5][6][7] The capabilities of photons as reactants, [8][9][10][11][12][13] capable of promoting the chemical conversion of a substrate without leaving traces in the reaction vessel, have been fully exploited in the last two decades through the overwhelming achievements of visible-light photocatalysis (in most cases, of photoredox catalysis) in synthesis. [14][15][16][17][18][19] Such success has enabled the design of a plethora of versatile synthetic strategies, which have found wide application ranging from the synthesis of polyfunctionalized materials to the late-stage functionalization of bioactive molecules.…”

Photoinduced in situ generation of DNA-targeting ligands: DNA-binding and DNA-photodamaging properties of benzo[c]quinolizinium ions

“…Specifically, the styrylpyridine, which does not bind to DNA, can be delivered without effect to the binding site, where the DNA-binding benzoquinolizinium ligand can then be generated as needed upon irradiation. Notably, the use of light for the activation of photo-controllable DNA ligands offers several advantages because it is easy to apply, traceless, and non-invasive [19]. As a result, several photoactive compounds have been developed, whose DNAbinding properties can be efficiently switched on and off by light [14,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34].…”