Photochemical synthesis of Au nanostars on PMMA films by ethanol action as flexible SERS substrates for in-situ detection of antibiotics on curved surfaces

Barveen, Nazar Riswana; Wang, Tzyy-Jiann; Chang, Yuen‐Haw

doi:10.1016/j.cej.2021.134240

Cited by 45 publications

(22 citation statements)

References 69 publications

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“…We can see that the Ag NPs@W-PDMS SERS substrate exhibits a well-defined linear response (R 2 = 0.990), and thus has a quantitative detection capability. Moreover, the enhancement factor (EF) of the Ag NPs@W-PDMS SERS substrate was calculated using the formula EF = (I SERS /C SERS )/(I NR /C NR ), 40 where I SERS and I NR indicate the peak intensities of the probe molecule in the SERS spectra and normal Raman spectra and C SERS and C NR denote the probe molecule concentrations in the corresponding measurements, respectively. The Raman intensity at 1510 cm −1 was selected for quantitative calculations.…”

Section: Sers Performance Of Ag Nps@w-pdms Substratesmentioning

confidence: 99%

3D Flexible SERS Substrates Integrated with a Portable Raman Analyzer and Wireless Communication for Point-of-Care Application

Zhang

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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With the development of flexible surface-enhanced Raman spectroscopy (SERS) substrates that can realize rapid in situ detection, the SERS technique accompanied by miniaturized Raman spectrometers holds great promise for point-of-care testing (POCT). For an in situ detection strategy, constructing high-performance flexible and transparent SERS substrates through a facile and cost-effective fabrication method is critically important. Herein, we present a simple method for fabricating a large-area flexible and transparent SERS substrate consisting of a silver-nanoparticle-grafted wrinkled polydimethylsiloxane (Ag NPs@W-PDMS) film, using a surface-wrinkling technique and magnetron sputtering technology. By characterizing rhodamine 6G as a probe molecule with a portable Raman spectrometer, the flexible SERS substrate shows a low detection limit (10–7 M), a high enhancement factor (6.11 × 106), and excellent spot–spot and batch–batch reproducibilities (9.0% and 4.2%, respectively). Moreover, the Ag NPs@W-PDMS substrate maintains high SERS activity under bending and twisting mechanical deformations of over 100 cycles, as well as storage in air for 30 days. To evaluate its practical feasibility, in situ detection of malachite green on apple and tomato peels is performed with a detection limit of 10–6 M. In addition, for point-of-care analysis, we develop a wireless transmission system to transmit the collected SERS spectral data to a computer in real time for signal processing and analysis. Therefore, the proposed Ag NPs@W-PDMS SERS substrate fabricated through a simple and mass-producible method, combined with the utilization of a portable Raman spectrometer and wireless communication, offers a promising opportunity to extend the SERS technique from the laboratory to POCT applications.

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Section: Sers Performance Of Ag Nps@w-pdms Substratesmentioning

confidence: 99%

3D Flexible SERS Substrates Integrated with a Portable Raman Analyzer and Wireless Communication for Point-of-Care Application

Zhang

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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“…Surface-enhanced Raman scattering (SERS) is an ultra-sensitive and advanced analytical tool which can enormously amplify the Raman signal intensity of molecules adsorbed on the rough surface of metallic nanostructures by more than 10–14 orders of magnitude. − SERS has been widely applied in food safety, biomedical, environmental monitoring and public safety, and other fields due to its fingerprint specificity, high sensitivity, rapid analysis speed, and simple sample pretreatment. Nowadays, enormous efforts have been devoted to nanoparticles with various structures to maximize the electromagnetic mechanism and chemical mechanism effects for excellent SERS performance. , Au nano-star (AuNS) is a kind of anisotropic nanoparticle with a central core and multiple protruding tips which can provide more abundant “hot spots” around the special tips compared to spherical NPs . Furthermore, the satisfying chemical stability, biocompatibility, and easy functionalization of AuNSs make it an ideal nanostructure for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

“…19,20 kind of anisotropic nanoparticle with a central core and multiple protruding tips which can provide more abundant "hot spots" around the special tips compared to spherical NPs. 21 Furthermore, the satisfying chemical stability, biocompatibility, and easy functionalization of AuNSs make it an ideal nanostructure for biomedical applications. In addition to colloidal suspensions of metal nanoparticles, large-scale solid SERS substrate is the other premise of obtaining excellent SERS signals, and the structurally nonuniform SERS substrates would induce the "hot spots" inhomogeneous distribution, resulting in poor signal uniformity and eventually difficulty in quantitative detection.…”

Section: Introductionmentioning

confidence: 99%

LoC-SERS Platform Integrated with the Signal Amplification Strategy toward Parkinson’s Disease Diagnosis

Cao

Chen

et al. 2023

ACS Appl. Mater. Interfaces

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Multiplexed detection of Parkinson's disease (PD) biomarkers is of great significance for early diagnosis and personalized treatment. In this study, we fabricated a robust surface-enhanced Raman scattering-enabled lab-on-a-chip (LoC-SERS) platform for simultaneous quantification of α-synuclein, phosphorylated tau protein 181, osteopontin, and osteocalcin. Herein, the antibody−DNA conjugate was designed to introduce the catalytic hairpin self-assembly (CHA) amplification into the protein detection. Au nano-stars (AuNSs) modified with Raman reporter molecules and hairpin-structure DNA 1 were applied as the SERS nanotags. Au-coated silicon nanocone array (Au/ SiNCA) fabricated based on the maskless plasma etching-prepared high-density Si nanocone array (SiNCA) and surface ion sputtering was used as the capture substrate after the modification of hairpin-structure DNA 2. Benefitting from the antibody−DNA conjugateinduced CHA amplification, numerous AuNSs can be connected to the Au/SiNCA surface, which significantly amplify the plasmonic coupling effect for ultrasensitive SERS detection, and the limit of detection was less than the pg/mL level. The application of highly uniform Au/SiNCA and antibody−DNA conjugate endows the LoC-SERS platform excellent analytical performance, including superior reproducibility, satisfactory universality, and high sensitivity. In addition, a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice model was established, and satisfactory results were obtained in real sample analysis with the LoC-SERS platform, which may be enlightening for exploiting protein biomarkers in PD monitoring.

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“…The advantages of such flexible substrates over rigid SERS substrates include simply an adjustable size and shape of the substrate, swab or wrap sampling, and tunable SERS activity that, when combined with portable Raman devices, opens up new possibilities for non-destructive testing. Currently, the pros and cons of various types of flexible SERS substrates for the detection of pesticides in fruits and vegetables [ 34 , 35 , 36 ], antibiotics in food [ 37 , 38 ], as well as biomarkers in human serum [ 39 , 40 ] were demonstrated. Despite the advances in SERS detection, the development of new reproducible SERS-active substrates with a simple and cost-effective fabrication process remains relevant for the sensitive sensing of analytes.…”

Section: Introductionmentioning

confidence: 99%

Flexible Substrate of Cellulose Fiber/Structured Plasmonic Silver Nanoparticles Applied for Label-Free SERS Detection of Malathion

et al. 2023

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Surface-enhanced Raman scattering (SERS) is considered an efficient technique providing high sensitivity and fingerprint specificity for the detection of pesticide residues. Recent developments in SERS-based detection aim to create flexible plasmonic substrates that meet the requirements for non-destructive analysis of contaminants on curved surfaces by simply wrapping or wiping. Herein, we reported a flexible SERS substrate based on cellulose fiber (CF) modified with silver nanostructures (AgNS). A silver film was fabricated on the membrane surface with an in situ silver mirror reaction leading to the formation of a AgNS–CF substrate. Then, the substrate was decorated through in situ synthesis of raspberry-like silver nanostructures (rAgNS). The SERS performance of the prepared substrate was tested using 4-mercaptobenzoic acid (4-MBA) as a Raman probe and compared with that of the CF-based plasmonic substrates. The sensitivity of the rAgNS/AgNS–CF substrate was evaluated by determining the detection limit of 4-MBA and an analytical enhancement factor, which were 10 nM and ~107, respectively. Further, the proposed flexible rAgNS/AgNS–CF substrate was applied for SERS detection of malathion. The detection limit for malathion reached 0.15 mg/L, which meets the requirements about its maximum residue level in food. Thus, the characteristics of the rAgNS/AgNS–CF substrate demonstrate the potential of its application as a label-free and ready-to-use sensing platform for the SERS detection of trace hazardous substances.

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Photochemical synthesis of Au nanostars on PMMA films by ethanol action as flexible SERS substrates for in-situ detection of antibiotics on curved surfaces

Cited by 45 publications

References 69 publications

3D Flexible SERS Substrates Integrated with a Portable Raman Analyzer and Wireless Communication for Point-of-Care Application

3D Flexible SERS Substrates Integrated with a Portable Raman Analyzer and Wireless Communication for Point-of-Care Application

LoC-SERS Platform Integrated with the Signal Amplification Strategy toward Parkinson’s Disease Diagnosis

Flexible Substrate of Cellulose Fiber/Structured Plasmonic Silver Nanoparticles Applied for Label-Free SERS Detection of Malathion

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