Photochemical, thermal, biological and long-term degradation of celecoxib in river water. Degradation products and adsorption to sediment

Jiménez, Juan J.; Pardo, Rafael; Sánchez, María Cristina Polo; Muñoz, Beatriz E.

doi:10.1016/j.jhazmat.2017.08.037

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…3% over 36 weeks when water was kept at room temperature, and exposure to sunlight was partially limited. Eleven degradation products were detected, and the structures of nine of them were unambiguously proposed [36]. Vora et al performed a degradation of etoricoxib in 1 M HCl, 1 M NaOH and hydrogen peroxide, in a water bath at 80 • C for 4 h. Photolytic and thermal degradation of the substance was performed by exposing to short wavelength light (254 nm) and high temperature (105 • C) for 4 days.…”

Section: Product Name Pathwaymentioning

confidence: 99%

“…There are several studies available, in which the degradation for a representative of the coxib group, etoricoxib, was carried out in both an acidic and alkaline environment [30][31][32][33]. Other studies present the analysis of celecoxib degradation in various environments [34][35][36]. A forced degradation trial of firocoxib under different stress conditions (acidic, alkaline, oxidative, thermal and photoinduced) was conducted, as recommended in the ICH guidelines [37].…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive Assessment of the Stability of Selected Coxibs in Variable Environmental Conditions along with the Assessment of Their Potential Hepatotoxicity

Gumułka,

Pecio,

Żmudzki

et al. 2023

Pharmaceutics

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Determining the influence of environmental factors on the stability of drugs is very helpful when choosing excipients, storage conditions or packaging materials. In addition, information about possible toxic degradation products enables detecting and avoiding the harmful side effects of the drug. We used the thin-layer chromatographic-densitometric procedure for the assay of five coxibs, conducted degradation studies in various environments and at different temperatures along with the determination of pharmacokinetic parameters. The results were subjected to chemometric analysis, to investigate and visualize the similarities and differences of the studied coxibs. Samples of the tested drug were also analyzed by UPLC-MS/MS in order to identify degradation products, and determine possible drug degradation pathways. Using the human liver cancer HepG2 cell line, the hepatotoxic effect of the degradation products was also determined. It was observed that all substances were relatively stable under the analyzed conditions and degraded more in acidic than alkaline environments. Robenacoxib is the drug that decomposes the fastest, and cimicoxib turned out to be the most stable. Robenacoxib also showed significant hepatotoxicity at the highest tested concentration, which correlates with the high degree of its degradation, and the probable formation of a more hepatoxic product. The obtained mass spectra of compounds formed as a result of hydrolysis of the protonated drug leading to the formation of several product ions, which enabled us to propose probable degradation pathways.

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Section: Product Name Pathwaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comprehensive Assessment of the Stability of Selected Coxibs in Variable Environmental Conditions along with the Assessment of Their Potential Hepatotoxicity

Gumułka,

Pecio,

Żmudzki

et al. 2023

Pharmaceutics

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“…For example, the sunlight exposure of Diclofenac has been investigated in solution or topical formulations [ 7 ], but its photoproducts are frequently detected in seawater and other aquatic environments [ 9 ]. Likewise, Celecoxib has been detected in river water, in which it is not biologically degraded but only minimally altered after exposure to sunlight or high temperature [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Photodegradation of Anti-Inflammatory Drugs: Stability Tests and Lipid Nanocarriers for Their Photoprotection

et al. 2021

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The present paper provides an updated overview of the methodologies applied in photodegradation studies of non-steroidal anti-inflammatory drugs. Photostability tests, performed according to international standards, have clearly demonstrated the photolability of many drugs belonging to this class, observed during the preparation of commercial forms, administration or when dispersed in the environment. The photodegradation profile of these drugs is usually monitored by spectrophotometric or chromatographic techniques and in many studies the analytical data are processed by chemometric procedures. The application of multivariate analysis in the resolution of often-complex data sets makes it possible to estimate the pure spectra of the species involved in the degradation process and their concentration profiles. Given the wide use of these drugs, several pharmaceutical formulations have been investigated to improve their photostability in solution or gel, as well as the pharmacokinetic profile. The use of lipid nanocarriers as liposomes, niosomes or solid lipid nanoparticles has demonstrated to both minimize photodegradation and improve the controlled release of the entrapped drugs.

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Degradation of fenamates

Kazi,

Sheraz,

Ahmed

et al. 2024

Profiles of Drug Substances, Excipients and Related Methodology

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Photochemical, thermal, biological and long-term degradation of celecoxib in river water. Degradation products and adsorption to sediment

Cited by 6 publications

References 10 publications

Comprehensive Assessment of the Stability of Selected Coxibs in Variable Environmental Conditions along with the Assessment of Their Potential Hepatotoxicity

Comprehensive Assessment of the Stability of Selected Coxibs in Variable Environmental Conditions along with the Assessment of Their Potential Hepatotoxicity

Photodegradation of Anti-Inflammatory Drugs: Stability Tests and Lipid Nanocarriers for Their Photoprotection

Degradation of fenamates

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