Photochemical tuning of materials: A click chemistry perspective

Kaur, Gurpreet; Singh, Gurjaspreet; Singh, Jandeep

doi:10.1016/j.mtchem.2018.03.002

Cited by 50 publications

(29 citation statements)

References 318 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, hyaluronic acid (HA) was modified with 6‐maleimidocaproic acid (MDA) via esterification between the carboxyl group of MDA and the hydroxyl of HA. Then the DOX conjugated peptide was grafted on HA‐MDA by Michael addition reaction to obtain the HA‐Psi‐DOX prodrug. The enzyme substrate peptide was introduced to induce drug release after cleaved by tumor overexpressed MMP‐2.…”

Section: Resultsmentioning

confidence: 99%

PD‐1 Blockade for Improving the Antitumor Efficiency of Polymer–Doxorubicin Nanoprodrug

Gao

Zhang

Qiu

et al. 2018

Small

View full text Add to dashboard Cite

Chemotherapy is well recognized to induce immune responses during some chemotherapeutic drugs-mediated tumor eradication. Here, a strategy involving blocking programmed cell death protein 1 (PD-1) to enhance the chemotherapeutic effect of a doxorubicin nanoprodrug HA-Psi-DOX is proposed and the synergetic mechanism between them is further studied. The nanoprodrugs are fabricated by conjugating doxorubicin (DOX) to an anionic polymer hyaluronic acid (HA) via a tumor overexpressed matrix metalloproteinase sensitive peptide (CPLGLAGG) for tumor targeting and enzyme-activated drug release. Once accumulated at the tumor site, the nanoprodrug can be activated to release antitumor drug by tumor overexpressed MMP-2. It is found that HA-Psi-DOX nanoparticles can kill tumor cells effectively and initiate an antitumor immune response, leading to the upregulation of interferon-γ. This cytokine promotes the expression of programmed cell death protein-ligand 1 (PD-L1) on tumor cells, which will cause immunosuppression after interacting with PD-1 on the surface of lymphocytes. The results suggest that the therapeutic efficiency of HA-Psi-DOX nanoparticles is significantly improved when combined with checkpoint inhibitors anti-PD-1 antibody (α-PD1) due to the neutralization of immunosuppression by blocking the interaction between PD-L1 and PD-1. This therapeutic system by combining chemotherapy and immunotherapy further increases the link between conventional tumor therapies and immunotherapy.

show abstract

Section: Resultsmentioning

confidence: 99%

PD‐1 Blockade for Improving the Antitumor Efficiency of Polymer–Doxorubicin Nanoprodrug

Gao

Zhang

Qiu

et al. 2018

Small

View full text Add to dashboard Cite

show abstract

“…[11][12][13] Indeed, the use of light to control the course of a (bio)chemical reaction is an attractive idea due to its ease of establishing high precision and fine spatial resolution. [14] For instance, relevant to the area of bioadhesion, numerous examples of rare and exciting phenomena have been reported. [15][16][17] Particularly, a photoconjugation strategy based on light-triggered Diels-Alder addition of o-quinodimethanes is compatible with biomolecules and proceeds rapidly at ambient temperature without the need of a catalyst.…”

Section: Research Activities In Smlmentioning

confidence: 99%

Soft Matter Technology at KIT: Chemical Perspective from Nanoarchitectures to Microstructures

et al. 2019

View full text Add to dashboard Cite

Bioinspiration has emerged as an important design principle in the rapidly growing field of materials science and especially its subarea, soft matter science. For example, biological cells form hierarchically organized tissues that not only are optimized and designed for durability, but also have to adapt to their external environment, undergo self‐repair, and perform many highly complex functions. Being able to create artificial soft materials that mimic those highly complex functions will enable future materials applications. Herein, soft matter technologies that are used to realize bioinspired material structures are described, and potential pathways to integrate these into a comprehensive soft matter research environment are addressed. Solutions become available because soft matter technologies are benefitting from the synergies between organic synthesis, polymer chemistry, and materials science.

show abstract

“…A linker with complementary functional groups is commonly used for click reaction crosslinking. Several biocompatible click reactions have been employed to obtain smart biomaterials and to impart them with new biological functionalities (Nimmo and Shoichet, 2011 ; Russo et al, 2011 , 2014 , 2016 ; Azagarsamy and Anseth, 2013 ; Lin et al, 2013 ; Gandavarapu et al, 2014 ; Nair et al, 2014 ; Taraballi et al, 2014 ; Huynh et al, 2018 ; Kaur et al, 2018 ). However, the application of these procedures on heterogeneous systems is of growing interest in materials science also for the improvement of bioprinting hybrid polymer procedures.…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Chitosan—Gelatin Hybrid Hydrogels for 3D Printable in vitro Models

et al. 2020

View full text Add to dashboard Cite

The development of 3D printable hydrogels based on the crosslinking between chitosan and gelatin is proposed. Chitosan and gelatin were both functionalized with methyl furan groups. Chemical modification was performed by reductive amination with methyl furfural involving the lysine residues of gelatin and the amino groups of chitosan to generate hydrogels with tailored properties. The methyl furan residues present in both polymers were exploited for efficient crosslinking via Diels-Alder ligation with PEG-Star-maleimide under cell-compatible conditions. The obtained chitosan-gelatin hybrid was employed to formulate hydrogels and 3D printable biopolymers and its processability and biocompatibility were preliminarily investigated.

show abstract

Photochemical tuning of materials: A click chemistry perspective

Cited by 50 publications

References 318 publications

PD‐1 Blockade for Improving the Antitumor Efficiency of Polymer–Doxorubicin Nanoprodrug

PD‐1 Blockade for Improving the Antitumor Efficiency of Polymer–Doxorubicin Nanoprodrug

Soft Matter Technology at KIT: Chemical Perspective from Nanoarchitectures to Microstructures

Design and Synthesis of Chitosan—Gelatin Hybrid Hydrogels for 3D Printable in vitro Models

Contact Info

Product

Resources

About