Photochemically induced fluorimetric determination of the antimalarial mefloquine

Fidanza, Joëlle; Aaron, J. J.

doi:10.1016/s0003-2670(00)82677-x

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…25–27 We identified a paper by Berens et al describing an aptamer capable of generating enhanced fluorescence upon binding to the antibiotic tetracycline and were able to replicate published results in our experimental setup with an obtained sample – we mixed the aptamer probe with tetracycline solution in a microwell plate and measured the emitted fluorescent signal using a spectrophotometer. 26,28,29 We also considered chemical probes as their interactions may function over a wider temperature range, and identified papers from Fletcher et al , Fidanza et al , and Tønnesen et al for fluorescence-based quantification of the APIs quinine sulfate and mefloquine, two antimalarial drugs with known substandard and falsification issues; 30–32 using a similar micro-well plate and spectrophotometer setup, we were able to replicate these published results as well.…”

Section: The First Ten Years Of Scientific and Engineering Efforts To...mentioning

confidence: 64%

PharmaChk: a decade of research and development towards the first quantitative, field-based medicine quality screening instrument

Acevedo

Desai

Zaman

et al. 2022

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Section: The First Ten Years Of Scientific and Engineering Efforts To...mentioning

confidence: 64%

PharmaChk: a decade of research and development towards the first quantitative, field-based medicine quality screening instrument

Acevedo

Desai

Zaman

et al. 2022

Analyst

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“…Thus, it is imperative to develop cheap, robust and accurate analytical methods for quantitative analysis of the antimalarial drug. Various methods have been developed for MQ determination, such as spectrophotometric, chromatographic, electrochemical and fluorometric methods . Among these, the voltammetric methods are well known for detection of various organic and inorganic compounds on account of their high selectivity, sensitivity and reliability at a low cost with the instrumentation having a potential for miniaturization and automation .…”

Section: Introductionmentioning

confidence: 99%

A Simple, Efficient and Ultrasensitive Gold Nanourchin Based Electrochemical Sensor for the Determination of an Antimalarial Drug: Mefloquine

et al. 2017

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Mefloquine (MQ) is a quinoline based antimalarial drug, which is potent against multiple drug‐resistant Plasmodium falciparum. It is widely prescribed for the prophylactic treatment of malaria. Due to extensive usage of MQ, constant monitoring of the drug level in human body is of paramount importancein order to ensure that optimum drug exposure is achieved. The present work describes a gold nanourchins (AuNUs) based electrochemical sensor for the determination of MQ.AuNUs were synthesized via seed‐mediated method and characterized using ultraviolet‐visible spectroscopy, energy‐dispersive X‐ray spectroscopy, field emission scanning electron microscopy, zeta‐sizer and electrochemical techniques (electrochemical impedance spectroscopy and cyclic voltammetry). Fabrication of the sensor was done by drop‐coating the synthesized AuNUs onto a glassy carbon electrode. The fabricated sensor exhibited enhanced voltammetric response, which was attributed to the excellent conductivity and high surface area of AuNUs. Under optimum square wave voltammetric conditions, the sensor displayed two linear response ranges (from 2.0×10−9 to 1.0×10−6 M and from 1.0×10−6 to 1.0×10−3 M) with a detection limit of 1.4 nM. The electrode demonstrated good reproducibility, stability and selectivity over common interferents. The utility of the sensor was successfully assessed for quantification of the drug in pharmaceutical preparation and spiked human urine sample. Thus, the present study demonstrates a promising approach for determination of MQ with practical utility in quality control and clinical analysis.

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“…Different methods of analysis had been reported such as spectrophotometry [7], fluorimetry [8], HPLC [9 -21] and gas chromatography [22,23]. Most of them are complicated, time consuming and need sophisticated equipments such as HPLC or gas chromatography.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Investigation and Determination of Mefloquine

2005

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The electrochemical reduction behavior of mefloquine HCl (MEF), the antimalarial drug, was studied in aqueous alcoholic media at a hanging mercury drop electrode. Cyclic voltammetric studies showed one well-defined reduction peak and one ill-defined reduction wave between pH 1.5 and 12.03. The reduction was found as irreversible or quasireversible depending on pH and exhibited diffusion controlled process. The mechanism of reduction process was discussed. A systematic study of the experimental parameters that affect the differential pulse and square wave response was carried out and the optimized experimental conditions were obtained. The calibration plots were derived for the determination of MEF in pharmaceutical dosage forms and biological samples. DPV and SWV techniques for the determination of MEF in Britton -Robinson buffer at pH 11.10, which allows quantitation over the 6 Â 10 À6 to 8 Â 10 À5 M range in the supporting electrolyte, were proposed. The linear response was obtained in samples in the ranges of 6 Â 10 À6 to 6 Â 10 À5 M for both techniques. These methods are fully validated. The standard addition method was used in the biological media. No electroactive interferences from the excipients and endogenous substances were found in tablets and biological fluids.

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Photochemically induced fluorimetric determination of the antimalarial mefloquine

Cited by 9 publications

References 16 publications

PharmaChk: a decade of research and development towards the first quantitative, field-based medicine quality screening instrument

PharmaChk: a decade of research and development towards the first quantitative, field-based medicine quality screening instrument

A Simple, Efficient and Ultrasensitive Gold Nanourchin Based Electrochemical Sensor for the Determination of an Antimalarial Drug: Mefloquine

Voltammetric Investigation and Determination of Mefloquine

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