Photochemistry of complex ions. V. Photochemistry of some square-planar platinum(II) complexes

Perumareddi, Jayarama R.; Adamson, Arthur W.

doi:10.1021/j100848a006

Cited by 81 publications

(50 citation statements)

References 2 publications

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“…For example, the photoaquation of cisand trans-[Pt(NH 3 ) 2 Cl 2 ], with the concomitant release of chlorido ligands, has been previously reported and the quantum yield values for the photolysis reaction of both isomers determined [20]. Additionally, irradiation of trans-[Pt(NH 3 ) 2 of photoactivation may provide a mechanism for activation of the inactive trans complex [21].…”

Section: Irradiation Of Trans-[pt II Cl 2 (Ipa)(ma)] (2) In Aqueous Smentioning

confidence: 94%

“…Photolytic reactions of square-planar platinum(II) complexes in aqueous solutions include photoaquation and photoisomerizations [18,20,22]. For example, the photoaquation of cisand trans-[Pt(NH 3 ) 2 Cl 2 ], with the concomitant release of chlorido ligands, has been previously reported and the quantum yield values for the photolysis reaction of both isomers determined [20].…”

Section: Irradiation Of Trans-[pt II Cl 2 (Ipa)(ma)] (2) In Aqueous Smentioning

confidence: 99%

“…Photoactivable Pt IV -azide complexes represent a promising area for new drug development [15][16][17]. [18][19][20]. UVA light promotes the loss of the second chlorido of transplatin and also promotes DNA binding and cytotoxicity [21].…”

Section: Introductionmentioning

confidence: 99%

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Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides

Cubo

Pizarro

Quiroga

et al. 2010

Journal of Inorganic Biochemistry

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We show that UVA irradiation (365 nm) of the Pt IV complex trans,trans,trans-[Pt IV Cl 2 (OH) 2 (dimethylamine)(isopropylamine)], 1, induces reduction to Pt II photoproducts. For the mixed amine Pt II complex, trans-[Pt II Cl 2 (isopropylamine)(methylamine)] (2), irradiation at 365 nm increases the rate and extent of hydrolysis, triggering the formation of diaqua species. Additionally, irradiation increases the extent of reaction of complex 2 with guanosine-5′-monophosphate (GMP) and affords mainly the bis-adduct, while reactions with adenosine-5′-monophosphate (AMP) and cytidine-5′-monophosphate (CMP) give rise only to mono-nucleotide adducts. Density Functional Theory calculations have been used to obtain insights into the electronic structure of complexes 1 and 2, and their photophysical and photochemical properties. UVA-irradiation can contribute to enhanced cytotoxic effects of diamine platinum drugs with trans geometry.

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Section: Irradiation Of Trans-[pt II Cl 2 (Ipa)(ma)] (2) In Aqueous Smentioning

confidence: 94%

Section: Irradiation Of Trans-[pt II Cl 2 (Ipa)(ma)] (2) In Aqueous Smentioning

confidence: 99%

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Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides

Cubo

Pizarro

Quiroga

et al. 2010

Journal of Inorganic Biochemistry

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“…The aquo ligand is in equilibrium with its deprotonated hydroxo form. The pKA values are 5.6 for the diaquo species and 7.3 for the monoaquomonohydroxo and monoaquomonochloride species [55][56][57]. The hydroxo moiety forms a stable bond with platinum while water is a good leaving group.…”

Section: The Reaction Of Cisplatin With Dna In Vitromentioning

confidence: 99%

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Johnson

Butour

Villani

et al. 1989

Progress in Clinical Biochemistry and Medicine

164

122

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Cisplatin (cis-diamminedichloroplatinum(II») is widely used in the treatment of testicular and ovarian cancers. A number of biological and biochemical results indicate that the reaction of cisplatin with DNA is responsible for the cytotoxic action of this drug. The effect of platinum compounds on the conformation and stability of DNA has been investigated and several platinum-DNA adducts have been identified in vitro and in vivo. Preliminary experiments have quantified the effect of these different lesions on DNA replication, their capacity to induce mutations and their susceptibility to DNA repair processes. Additional DNA damage may be created by platinum(IV) compounds, perhaps during their reduction to platinum(II) compounds by the cell.

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“…In the absence of arsenic, the aqueous solution of aqua-cisPt acetate alone was unstable with or without liposomes, and changed into brown and then black after one month at 4 8C, perhaps due either to photosensitivity [27] or to the formation of platinum carbonato complexes upon absorption of CO 2 from air. [28] The As-Pt coencapsulation strategy described here provides a way of stably sequestering both arsenic and platinum drugs within liposomal cores: drug release studies reveal high stability of NB(As, Pt) under physiologically relevant conditions.…”

mentioning

confidence: 99%

Coencapsulation of Arsenic‐ and Platinum‐based Drugs for Targeted Cancer Treatment

et al. 2009

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Photochemistry of complex ions. V. Photochemistry of some square-planar platinum(II) complexes

Cited by 81 publications

References 2 publications

Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides

Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Coencapsulation of Arsenic‐ and Platinum‐based Drugs for Targeted Cancer Treatment

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