Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet Light

Parrish, John A.; Fitzpatrick, Thomas B.; Tanenbaum, Lewis; Pathak, Madhu A.

doi:10.1056/nejm197412052912301

Cited by 1,331 publications

(442 citation statements)

References 23 publications

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“…Psoralen is a furocoumarin that has long been used with UV A radiation to treat psoriasis and other skin conditions (Parrish et al, 1974) and more recently has been associated with higher risk of squamous cell cancer (Lever and Farr, 1994;Stern et al, 1998) and melanoma (Stern et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Dietary intakes of vitamins A, C, and E and risk of melanoma in two cohorts of women

et al. 2003

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Within the two Nurses' Health Study cohorts of US women, we examined whether higher intakes of vitamin C, vitamin E, retinol, or individual tocopherols or carotenoids are associated with a lower risk of melanoma. We confirmed 414 cases of invasive melanoma among over 162 000 Caucasian women aged 25 -77 years during more than 1.6 million person-years of follow-up. Diet was measured every 4 years with a food frequency questionnaire and supplement use was reported every 2 years. Several measures of sun sensitivity were assessed and included in proportional hazards models. We found that vitamins A, C, E and their individual components were not associated with a lower risk of melanoma. Only retinol intake from foods plus supplements appeared protective within a subgroup of women who were otherwise at low risk based on nondietary factors (relative risk (RR) ¼ 0.39, 95% confidence interval (CI) 0.22 -0.71 for X1800 vs o400 mg day À1 , P for linear trend ¼ 0.01). Contrary to expectation, we observed higher risks of melanoma with greater intakes of vitamin C from food only (RR ¼ 1.43, 95% CI 1.01 -2.00 for X175 vs o90 mg day À1 , P for linear trend ¼ 0.05) and a significant positive dose -response with frequency of orange juice consumption (P ¼ 0.008). Further research is needed to determine whether another component in foods such as orange juice may contribute to an increase in risk.

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Section: Discussionmentioning

confidence: 99%

Dietary intakes of vitamins A, C, and E and risk of melanoma in two cohorts of women

et al. 2003

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“…Oxygen and its activated intermediates, ROS (reactive oxygen species), however, may react with cellular components with resultant degradation or inactivation of essential molecules. 5,13 Oxidative stress 5,10-13 is not simply an undesirable consequence of aerobic life (Scheme 1). 12 It also represents an important principle of the organism chemical defence against invaders, generated by neutrophilic granulocytes during phagocytosis.…”

Section: Electron Transfer (Et)-oxidative Stress (Os) Theorymentioning

confidence: 99%

“…Examples include oxidation of various positions of pyrimidines (2) and purines (3, 4), with 8-hydroxyguanine (3) usually being the focus of attention, and hydrogen atom abstraction at the sugar moieties giving rise to carbon-based radicals which in the presence of oxygen undergo a number of reactions, including C-C bond fragmentation, some of which result in single-strand breaks. 13 Being among the best hydrogen atom acceptors, hydroxyl radicals are prone to induce a large variety of biological mutations and to disrupt the cohesion of cellular membranes via radical peroxidation of cell bilipids. Severe oxidative stress can cause cell injury or death as a consequence of insufficient antioxidant potential.…”

Section: Electron Transfer (Et)-oxidative Stress (Os) Theorymentioning

confidence: 99%

“…13 ET-OS represents a broad and unifying understanding of drug-action that can aid in the design of new drugs. 5,10…”

Section: Electron Transfer (Et)-oxidative Stress (Os) Theorymentioning

confidence: 99%

“…63 It was found that metronidazole (13) was only toxic at extremely low oxygen concentration, whereas nitrofurazone (34) was toxic at substantially greater concentrations of oxygen. This difference can be rationalised by the large variation in redox potential.…”

Section: Generalitiesmentioning

confidence: 99%

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Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Abreu¹,

Ferraz²,

Goulart³

2002

J. Braz. Chem. Soc.

154

124

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Essa revisão resume alguns dos aspectos mais relevantes na correlação entre processos e parâmetros eletroquímicos e atividades biológicas, relacionadas, principalmente, a doenças tropicais e câncer. Apesar da gama de possibilidades e da complexidade da química celular/tecidual/extracelular, é possível racionalizar o papel da eletroquímica em poucas bases teóricas, principalmente: transferência eletrônica -estresse oxidativo, geração eletroquímica in situ de agentes tóxicos diferentes das espécies oxigenadas reativas, interação com endobióticos, com ênfase particular em alquilação biorredutiva e substituição de endobióticos com função em reações de oxi-redução biológicas. O uso de métodos eletroquímicos para a obtenção de mecanismos de ação de drogas e na análise de eventos celulares é também apresentado. Nessas correlações, métodos e/ou parâmetros eletroquímicos exercem papel relevante, porém, não absoluto.This review summarises some of the more relevant achievements in the correlation between electrochemical processes and parameters and bioactive properties, mainly related to cancer and tropical diseases. Despite the broad range of possibilities and the complexity of cell/tissue/extracell chemistry, it is possible to rationalise the role of electrochemistry in few basic theoretical frameworks, mainly, the one based on electron transfer-oxidative stress and in situ generation of toxic species, other than the reactive oxygen species; interaction with endobiotics, with emphasis on bioreductive alkylation and replacement of endobiotics with function in biological redox reactions. The use of electrochemical methods to obtain relevant informations about drugs' mechanism of action and analysis of cellular events is also presented. Electrochemical methods and/or parameters play essential but not absolute roles.

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Photochemotherapy of vitiligo. Use of orally administered psoralens and a high-intensity long-wave ultraviolet light system

Parrish¹,

Fitzpatrick²,

Shea³

et al. 1976

Archives of Dermatology

107

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A new light source that provides high-intensity ultraviolet light (UVA) (300 to 400 nm) to the entire body surface makes orally administered psoralen treatment of vitilligo with an artificial light practical. In the 26 patients studied, the degree of repigmentation with either trioxsalen (TMP) or methoxsalen (8-MOP) and high intensity UVA was at least as great as that with the same oral agents and sunlight. With artificial UVA and similar treatment conditions, the two psoralen derivatives were compared in the treatment of vitiligo; TMP stimulated repigmentation as well as 8-MOP and caused fewer side effects.

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Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet Light

Cited by 1,331 publications

References 23 publications

Dietary intakes of vitamins A, C, and E and risk of melanoma in two cohorts of women

Dietary intakes of vitamins A, C, and E and risk of melanoma in two cohorts of women

Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Photochemotherapy of vitiligo. Use of orally administered psoralens and a high-intensity long-wave ultraviolet light system

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