In this article, the performance of a meander-line-based microstrip patch antenna with split-ring resonator (SRR)-based slots and defected ground is analyzed at the terahertz frequency range. The designed antenna shows a multiband application within a frequency range of 3.77 to 6.60 THz and operates over six different frequencies (viz. 3.83 THz, 4.24 THz, 5.12 THz, 5.50 THz, 5.95 THz, and 6.50 THz). A maximum return loss of 37 is achieved over the band of 5.85 to 6.18 THz, while a maximum realized gain of 7.54 dBi and a total efficiency of 54% is obtained at 4.24 THz. The ground and radiating elements of the antenna are made of gold. Silicon dioxide is used as a substrate material. The antenna simulation is performed and reported in this study. The proposed antenna finds its applications in the detection of colon cancer, skin cancer, brain tumor, drug detection, and communication fields for point-to-point communication purposes. K E Y W O R D S defected ground, meander line, microstrip antenna, SRR slot, terahertz range 1This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.