Photocrosslinkable Chitosan Hydrogel Can Prevent Bone Formation in Both Rat Skull and Fibula Bone Defects

Tsuda, Yoshifumi; Amako, Masatoshi; Arino, Hiroshi; Hattori, Hidemi; Kanatani, Yasuhiro; Yura, Hirofumi; Nemoto, Koichi

doi:10.1111/j.1525-1594.2008.00676.x

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…Chitosan has been proposed for use as biomaterials due to its unique properties, including biodegradability, nontoxicity, antibacterial effect, biocompatibility, having the potential to encourage the differentiation of osteoprogenators cells and facilitate the formation of bone, and cost‐effective availability. Chitosan has been used successfully in tissue engineering studies with various cell types and also as a carrier for a number of growth factors7–9.…”

Section: Introductionmentioning

confidence: 99%

Particle size modeling and morphology study of chitosan/gelatin/nanohydroxyapatite nanocomposite microspheres for bone tissue engineering

Bagheri‐Khoulenjani

Mirzadeh

Etrati-Khosroshahi

et al. 2012

J Biomedical Materials Res

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In this study, nanocomposite microspheres based on chitosan/gelatin/nanohydroxyapatite were fabricated, and effects of the nanohydroxyapatite/biopolymer (chitosan/gelatin) weight ratio (nHA/P), stirring rate, chitosan concentration and biopolymer concentration on the particle size, and morphology of nanocomposite microspheres were investigated. Particle size of microspheres was modeled by design of experiments using the surface response method. Particle size, morphology of microspheres, and distribution of nanoparticles within the composite microspheres were evaluated using an optical microscope, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. X-ray diffraction and Fourier transform infrared spectroscopy were applied to study the physical and chemical characteristics of microspheres. Results showed that by modulating the nHA/P ratio, chitosan concentration, polymer concentration, and stirring rate, it is possible to fabricate microspheres in wide rages of particle size (5-150 μm). Analysis of variance confirmed that the modified quadratic model can be used to predict the particle size of nanocomposite microspheres within the design space. SEM studies showed that microspheres with different compositions had totally different morphologies from dense morphologies to porous ones. TEM images demonstrated that nanoparticles were distributed uniformly within the polymeric matrix. MTT assay and cell culture studies showed that microspheres with different compositions possessed good biocompatibility. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

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Section: Introductionmentioning

confidence: 99%

Particle size modeling and morphology study of chitosan/gelatin/nanohydroxyapatite nanocomposite microspheres for bone tissue engineering

Bagheri‐Khoulenjani

Mirzadeh

Etrati-Khosroshahi

et al. 2012

J Biomedical Materials Res

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“…Yoshifumi Tsuda et al. (92) of the National Defense Medical College, Tokorozawa, Saitama, Japan evaluated the ability of a photocrosslinkable chitosan to inhibit bone formation in the bone defects in rats. Bone formations in the rat skull (5 mm diameter) and fibula (2 mm) defects with photocrosslinkable chitosan hydrogel were significantly prevented for 8 weeks.…”

Section: Orthopedic and Neuromuscular Supportmentioning

confidence: 99%

Artificial Organs 2009: A Year in Review

Malchesky¹

2010

Artificial Organs

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In this editor's review, all articles published in 2009 are organized by category and briefly summarized. As Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level," we strive to publish the very best developments and clinical applications of artificial organ technologies in this broad and expanding field. In this editor's review, we aim to provide a reflection of the currently available worldwide knowledge that is intended to advance and improve human life while providing insight for continued application of technologies and methods of organ replacement, recovery, and regeneration. APHERESISClaudia Stefanutti et al. (1) of the University of Rome, Rome, Italy studied lowering lipoprotein Lp(a) using a reusable low density lipoprotein (LDL)-adsorber that allowed the removal of both LDL and Lp(a) from plasma. Two male patients with hyper-Lp(a) lipoproteinemia, without elevation of LDL-cholesterol, who had not responded to diet and medication were submitted to 50 LDL Lp(a) aphereses at weekly and biweekly intervals. Total cholesterol, LDL cholesterol, triglycerides, and Lp(a) plasma levels fell significantly. High density lipoprotein (HDL) cholesterol concentrations in plasma did not show a statistically significant change. Clinically, all sessions were well tolerated and no undesired reactions were reported. The adsorber's reusability for several sessions was confirmed.Claudia Stefanutti et al.(2) also reported on a multicenter study of therapeutic exchange (TPE) in patients with severe hypertriglyceridemia (sHTG). Seventeen patients who had not responded to conventional medical therapy (fat-free diet plus pharmaceutical interventions) were referred for TPE. Two hundred and seventeen TPE sessions were performed, and therapy is ongoing for 29.4% of the patients. After treatment, the mean plasma TG and total cholesterol concentrations were significantly reduced. The removal of triglyceride-richlipoproteins prevented relapses of acute pancreatitis. TPE provides a therapeutic option for preventing life-threatening sHTG. BLOOD SUBSTITUTESSabura Neya et al.(3) of Chiba University, Inage-Yayoi, Chiba, Japan evaluated the biological function of the core modified porphyrin isomers such as porphycene, corrphycene, and hemiporphycene. The iron complexes stoichiometrically coupled with apomyoglobin afford stable holoproteins. The oxygen affinity of the reconstituted myoglobins (Mb) changed over a 60 000-fold range depending on the

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“…More specifically, chitosan has been widely explored in the growing field of injectable hydrogels. Stimuli such as temperature, pH and UV‐irradiation, have been tuned to trigger chitosan gelation in situ following injection 9–12. Thermosensitive Chitosan/β‐Glycerophosphate hydrogels, extensively studied in the literature, were shown to gel in 4–9 minutes at 37 °C;13 thermosensitive PEG‐grafted chitosan was shown to undergo a sol‐gel transition in 10 ± 4 minutes;14 and pH‐sensitive chitosan/PVA hydrogels underwent gelation after 35 minutes 15.…”

mentioning

confidence: 99%

Rapid, Guanosine 5'‐Diphosphate‐Induced, Gelation of Chitosan Sponges as Novel Injectable Scaffolds for Soft Tissue Engineering and Drug Delivery Applications

Mekhail¹,

Daoud²,

Almazán

et al. 2013

Adv Healthcare Materials

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Photocrosslinkable Chitosan Hydrogel Can Prevent Bone Formation in Both Rat Skull and Fibula Bone Defects

Cited by 8 publications

References 14 publications

Particle size modeling and morphology study of chitosan/gelatin/nanohydroxyapatite nanocomposite microspheres for bone tissue engineering

Particle size modeling and morphology study of chitosan/gelatin/nanohydroxyapatite nanocomposite microspheres for bone tissue engineering

Artificial Organs 2009: A Year in Review

Rapid, Guanosine 5'‐Diphosphate‐Induced, Gelation of Chitosan Sponges as Novel Injectable Scaffolds for Soft Tissue Engineering and Drug Delivery Applications

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