Photocrosslinkable gelatin/collagen based bioinspired polyurethane-acrylate bone adhesives with biocompatibility and biodegradability

Balcıoğlu, Sevgi; Gürses, Canbolat; Özcan, İmren; Yıldız, Azibe; Köytepe, Süleyman; Parlakpınar, Hakan; Vardı, Nigar; Ateş, Burhan

doi:10.1016/j.ijbiomac.2021.09.043

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…A hydrogel is generally obtained by synthesis through the hydrolysis and condensation of the chosen precursors, causing the creation of a solid nanostructured network [ 199 ]. In this sense, for the synthesis of the hydrogel, most of the studies focus primarily on physical and chemical cross-linking methods ( Figure 3 ), and the current challenges by means of synthesis procedures are oriented to obtain structures with higher cross-linking density for specific applications such as limbal stem cells [ 200 ] or hard-tissue engineering [ 201 ] and the use of green alternative procedures, solvents and cross-linking agents to assess efficient hydrogel synthesis without impairing biological properties such as biocompatibility and cytotoxicity [ 202 , 203 , 204 ].…”

Section: Synthesis Of Hydrogelsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Synthesis Of Hydrogelsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…Molecular-modification, such as dopamine-modification, , has been used in much research for enhanced biocompatibility. Balcioglu et al fabricated a photo-cross-linkable aliphatic isophorone diisocyanate (IPDI) bone adhesive based on gelatin or collagen integrated with different weights of PEGs (P200, P400, and P600) (IPDI-GEL-PEG or IPDI-COL-PEG) (Figure a) . The adhesive strength of IPDI-GEL-PEG or IPDI-COL-PEG was also tested (Figure b).…”

Section: Bone Regenerative Fixationmentioning

confidence: 99%

“…Balcioglu et al fabricated a photo-cross-linkable aliphatic isophorone diisocyanate (IPDI) bone adhesive based on gelatin or collagen integrated with different weights of PEGs (P200, P400, and P600) (IPDI-GEL-PEG or IPDI-COL-PEG) ( Figure 4 a). 90 The adhesive strength of IPDI-GEL-PEG or IPDI-COL-PEG was also tested ( Figure 4 b). Results demonstrated that the adhesive strength of IPDI-GEL-P200-20-AC (390 kPa) is comparable to that of cyanoacrylate (403 kPa, a commercial adhesive).…”

Section: Bone Regenerative Fixationmentioning

confidence: 99%

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Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

et al. 2023

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Bone fractures have always been a burden to patients due to their common occurrence and severe complications. Traditionally, operative treatments have been widely used in the clinic for implanting, despite the fact that they can only achieve bone fixation with limited stability and pose no effect on promoting tissue growth. In addition, the nondegradable implants usually need a secondary surgery for implant removal, otherwise they may block the regeneration of bones resulting in bone nonunion. To overcome the low degradability of implants and avoid multiple surgeries, tissue engineers have investigated various biodegradable materials for bone regeneration, whereas the significance of stability of long-term bone fixation tends to be neglected during this process. Combining the traditional orthopedic implantation surgeries and emerging tissue engineering, we believe that both bone fixation and bone regeneration are indispensable factors for a successful bone repair. Herein, we define such a novel idea as bone regenerative fixation (BRF), which should be the main future development trend of biodegradable materials.

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“…Adhesives can be used as a suture in surgery or bonding hard/soft tissue, for instance, in skin incisions, nerve stumps, and tissue ducts. [ 187 ] Collagen‐based adhesion‐preventing agents prevent wounded areas from adhering to the surrounding tissue and accelerate the wound‐healing process. [ 188 ] We manufactured a multifunctional injectable adhesive double‐network hydrogel (DNGel) based on gelatin, which was prepared by facile dual‐syringe methodology (Figure 5B‐i).…”

Section: Applications Of Cbbsmentioning

confidence: 99%

A Review of Recent Progress on Collagen‐Based Biomaterials

Zheng

Wang

Ouyang

et al. 2022

Adv Healthcare Materials

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Since the 2010s, the demand for healthcare models has exceeded the prevailing resources available due to the rapid increase in the aging population in China. However, a significant gap in development of biomedical materials remains, especially between China and the western developed countries. Collagen is the major protein of the extracellular matrix (ECM) and has been extensively applied in medical fields. Collagen-based biomaterials (CBBs) are used to prepare dressings and dermal substitutes, surgical sutures, plasma substitutes, tissue-engineered scaffolds, and drug delivery systems; this is attributed to their exceptional biocompatibility, biodegradability, hypoimmunogenicity, and coordination between collagen hosts and tissues. This review provides thorough strides in CBB structures, crosslinking and forming technologies, and real-world applications. First, the natural origin and specific structures of animal-derived collagen and non-animal-derived collagen are introduced and compared. Second, crosslinking methods and forming technologies of CBBs across the board are discussed. Third, several examples are considered to demonstrate the practical biomedical use of CBBs and highlight cautionary notes. Finally, the underlying development directions of CBBs from an interdisciplinary perspective are outlined. This review aims to provide comprehensive mechanisms by which collagen can be uniquely and practically used as advanced biomaterial, hence providing options for augmenting its development in China.

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Photocrosslinkable gelatin/collagen based bioinspired polyurethane-acrylate bone adhesives with biocompatibility and biodegradability

Cited by 11 publications

References 36 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

A Review of Recent Progress on Collagen‐Based Biomaterials

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