Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

Pereira, Rúben F.; Bartolo, Paulo Jorge Da Silva

doi:10.1007/978-94-007-7073-7_8

Cited by 5 publications

(1 citation statement)

References 113 publications

(213 reference statements)

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“…In addition, certain natural polymers (e.g., collagen) also present cell-proteolytic domains and/or adhesion motifs, providing recognition sites for embedded cells and allowing the cellmediated degradation of the hydrogel network in a similar way to the remodelling of native ECM. Natural hydrogels, in particular protein-derived hydrogels, usually present concerns regarding weak mechanical properties, high immunogenicity and virus/disease transmission, though they retain their biological activity being the most widely used ECM-mimicking materials [47,147]. Synthetic hydrogels constitute an important alternative due to their controlled chemical composition and tuneable mechanical properties.…”

Section: Hydrogel Bioinksmentioning

confidence: 99%

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

et al. 2017

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Bioprinting technologies are powerful additive biofabrication techniques to produce cellular constructs for skin tissue engineering owing to their unique ability to precisely pattern living and non-living materials in predefined spatial locations. This unique feature, combined with the computer controlled printing and medical imaging techniques, enable researchers and clinicians to generate patient specific constructs partly replicating the intricate compositional and architectural organization of the skin. Bioprinting has been used to automatically dispense hydrogels with skin cells located in prescribed sites that promote skin formation in vitro and in vivo. Current skin bioprinting approaches mostly rely on the sequential printing of fibroblasts and keratinocytes embedded within a homogeneous hydrogel. Although such approaches have already been translated to pre-clinical scenarios, they still present limitations in terms of fully replicating the cellular and extracellular matrix (ECM) heterogeneity in native skin. The success of bioprinting for skin repair strongly depends on the design of printable bioinks capable of supporting the function of printed cells and stimulating the production of new ECM components. To better mimic the human skin, novel developments in dedicated bioprinting technologies, in the design of bioinks, as well as in the printing of vascularised constructs are necessary. This paper presents an overview regarding the use of bioprinting for skin tissue engineering applications. The operating principles of bioprinting technologies are outlined along with requirements of printed skin constructs. Finally, preclinical results are summarized and future perspectives for the field are highlighted.

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Section: Hydrogel Bioinksmentioning

confidence: 99%

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

et al. 2017

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Recent Progress on Polymer Materials for Additive Manufacturing

Tan

Zhu

Zhou

2020

Adv Funct Materials

488

238

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Additive manufacturing (AM) is the process of printing 3D objects in a layer-by-layer manner. Polymers and their composites are some of the most widely used materials in modern industries and are of great interest in the field of AM due to their vast potential for various applications, especially in the medical, aerospace, and automotive industries. Many studies have been conducted to develop new polymer materials for AM techniques, which include vat photopolymerization, material jetting, powder bed fusion, material extrusion, binder jetting, and sheet lamination. Although several reviews on the development of polymer materials for AM have been published, most of them only focus on a specific application, process, or type of material. Therefore, this article serves to provide a comprehensive review on the progress in polymer material development for AM techniques. It begins with an introduction to different AM techniques, followed by highlighting the progress of their development. Material requirements, notable advances in newly developed materials and their potential applications are discussed in detail and summarized. This review concludes by identifying the major challenges currently encountered in using AM for polymer materials and providing insights into the valuable opportunities it presents, in hopes of spurring further development in this field.

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3D bioprinting of photocrosslinkable hydrogel constructs

Pereira

Bartolo

2015

J of Applied Polymer Sci

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191

159

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Three‐dimensional (3D) bioprinting comprises a group of biofabrication technologies for the additive manufacturing of 3D constructs by precisely printing biocompatible materials, cells and biochemicals in predesigned spatial positions. These technologies have been successfully applied to fabricate biodegradable 3D constructs with intricate architectures and heterogeneous composition, assuming a pivotal role in the field of tissue engineering. However, the full implementation of bioprinting strongly depends on the development of novel biomaterials exhibiting fast crosslinking schemes and appropriate printability, cell‐compatibility and biomechanical properties. Photocrosslinkable hydrogels are attractive materials for bioprinting as they provide fast polymerization under cell‐compatible conditions and exceptional spatiotemporal control over the gelation process. Photopolymerization can also be performed during the bioprinting to promote the instantaneous formation of hydrogel with high well‐defined architecture and structural stability. In this review paper, we summarize the most recent developments on bioprinting of photocrosslinkable biodegradable hydrogels for tissue engineering, focusing on the chemical modification strategies and the combination of photocrosslinking reactions with other gelation modalities. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42458.

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Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

Cited by 5 publications

References 113 publications

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

Recent Progress on Polymer Materials for Additive Manufacturing

3D bioprinting of photocrosslinkable hydrogel constructs

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