Photocrosslinkable tissue adhesive based on dextran

Photo-irradiation paradigm: Mapping a remarkable facile technique used for advanced drug, gene and cell delivery

“…Several researchers have demonstrated the drug release profiles for photo-irradiated polysaccharides matrices. Dextran is a reputable natural polysaccharide that is widely used in the pharmaceutical field, as such; photo-cured dextran derivative containing methacrylate moieties represents a simple and reproducible procedure to obtain networks able to swell in aqueous medium to form a soft bioerodible matrix [77,85].…”

Studies of Phenol-Based Bioinspired Sealants

“…Recent examples of alternative materials include photo-cross-linkable bioadhesives based on star-shaped poly(d,l-lactide) [7], hydroxyl end functionalized PCL [8], PEG amine=dextran aldehyde composites [9,10], an amine-functionalized succinyl chitosan, an oxidized dextran [11], and dextran urethane [12].…”

Hydrogels from dextran and soybean oil by UV photo‐polymerization

“…Hydrogels can also have tailored mechanical properties ranging from soft to hard depending on their chemical structures and crosslinking density. 1,4,6,[8][9][10][11] Photo-crosslinking has many advantages such as good spatial and temporal control, which makes it an ideal approach for in situ formation of hydrogels. [2][3][4][5][6] The hydrophilic polymers which can be used for the preparation of hydrogels include natural polymers (e.g., polysaccharides, proteins and peptides, and nucleic acids) and synthetic polymers (e.g., polyethylene glycol based homo-and co-polymers, polyvinyl alcohols, hydroxyethylmethacrylate and acrylic acid based homo-and co-polymers).…”

“…The chemical composition, functionality and chain topology of the polymers play key roles in the determination of crosslinking density and the balance of hydrophilicity and hydrophobicity of hydrogels. 4 Polysaccharides, such as chitosan, 14 dextran, 6,11,[15][16][17] chondroitin sulfate, 12 alginate, 18 heparin, 19,20 agarose, 21,22 and hyaluronic acid, 23 are natural hydrophilic polymers. Chemical crosslinking can be formed via free radial photo-polymerization of (meth)acrylate (macro)monomers with multifunctional crosslinkers.…”

“…1,4,6,[8][9][10][11] Photo-crosslinking has many advantages such as good spatial and temporal control, which makes it an ideal approach for in situ formation of hydrogels. 1,6,24,25 Three hydroxyl groups per residue of anhydroglucose in dextran are available for chemical reactions and for functional modification. Iragure 2959 8,12 and 2,2-dimethoxy-2-phenyl acetophenone 13 ) absorb ultraviolet or visible light to generate free radicals which initiate polymerizations.…”