Photocrosslinked Poly(vinyl alcohol) Nanofibrous Scaffolds

Chen, Shaohua; Liu, Yuansen; Dong, Qi; Zhou, Yingshan; Yin, Xianze; Chen, Dongzhi; Xu, Chaochao; Xu, Weilin

doi:10.2494/photopolymer.29.841

Cited by 5 publications

(8 citation statements)

References 31 publications

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“…The synthesis route of photocrosslinked PVA–GMA/MSi nanocomposite hydrogels is shown in Figure a. PVA–GMA was synthesized by the ring-opening reaction and subsequent transesterification between PVA and GMA molecules as previously reported by our group . The structure of PVA–GMA was confirmed by the 1 H NMR spectra (Figure b).…”

Section: Resultsmentioning

confidence: 85%

“…When DS is higher than 0.03, the PVA–GMA aqueous solution became semitransparent cloudy solution, which probably affected follow-up photopolymerization. When DS exceeds 0.12, the PVA–GMA absolutely cannot dissolve in water probably because of the introduction of hydrophobic methacryloil groups with a considerable amount . However, the PVA–GMA can be dissolved in water to form a clear solution when DS is 0.01 (i.e., ∼1% of the OH of PVA reacted GMA and ∼99% of the OH of PVA remained), which could be quickly transformed into a hydrogel under the UV irradiation (Figure c).…”

Section: Resultsmentioning

confidence: 99%

“…PVA–GMA was prepared according to the method reported by us earlier . Briefly, 5.0 g of PVA was dissolved in 100 mL of dimethyl sulfoxide (DMSO).…”

Section: Methodsmentioning

confidence: 99%

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High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion

Zhang

Liang

Zhou

et al. 2018

ACS Appl. Mater. Interfaces

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Poly(vinyl alcohol) (PVA) hydrogels have been considered as promising implants for various soft tissue engineering applications because of their tissue-like viscoelasticity and biocompatibility. However, two critical barriers including lack of sufficient mechanical properties and non-tissue-adhesive characterization limit their application as tissue substitutes. Herein, PVA is methacrylated with ultralow degrees of substitution of methacryloyl groups to produce PVA-glycidyl methacrylate (GMA). Subsequently, the PVA-GMA/methacrylate-functionalized silica nanoparticle (MSi)-based nanocomposite hydrogels are developed via the photopolymerization approach. Interestingly, both PVA-GMA-based hydrogels and PVA-GMA/MSi-based nanocomposite hydrogels exhibit outstanding compressive properties, which cannot be damaged through compressive stress-strain tests in the allowable scope of a tensile tester. Moreover, PVA-GMA/MSi-based nanocomposite hydrogels demonstrate excellent tensile properties compared with neat PVA-GMA-based hydrogels, and 15-, 14-, and 24-fold increase in fracture stress, elastic modulus, and toughness, respectively, is achieved for the PVA-GMA/MSi-based hydrogels with 10 wt % of MSi. These remarkable enhancements can be ascribed to the amount of long and flexible polymer chains of PVA-GMA and the strong interactions between the MSi and PVA-GMA chains. More interestingly, exciting improvements in the cell adhesion can also be successfully achieved by the incorporation of MSi nanoparticles.

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Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

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High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion

Zhang

Liang

Zhou

et al. 2018

ACS Appl. Mater. Interfaces

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“…Synthesis of Glycidyl Methacrylate-Modified Poly(vinyl alcohol) (PVAGMA): PVAGMA was synthesized according to previously published work. [24,32,63,64] In brief, PVA powder (20 g) was dissolved in DMSO (400 mL) in a round bottom flask at 90 °C to obtain a PVA solution (5 wt%). DMAP (5 g), as a catalytic agent, was added after lowering the temperature to 60 °C, followed by adding different amounts of GMA, ranging from 1 to 10 mL.…”

Section: Methodsmentioning

confidence: 99%

Embedded 3D Printing of Ultrasound‐Compatible Arterial Phantoms with Biomimetic Elasticity

Chee

Golzar

et al. 2022

Adv Funct Materials

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Here, a class of ink materials and an embedded 3D printing strategy for the fabrication of macroscale elastic tissue‐mimetic constructs are presented. Novel inks composed of 10 wt% glycidyl methacrylated poly(vinyl alcohol) (PVAGMA) with different degrees of substitution (DOS) and 4 wt% cellulose nanocrystals (CNCs) (PVAGMA(DOS)/CNC) with strong shear‐thinning property are developed. By controlling the DOS of PVAGMA, hydrogels with desired mechanical stiffness mimicking that of healthy and diseased artery are designed to construct vascular phantoms. Cyclic tensile tests and in vitro hemodynamic study performed on phantoms demonstrate their excellent mechanical stability and low hysteresis. The burst pressure is found to be about 273 mmHg for PVAGMA2/CNC and 102 mmHg for PVAGMA4/CNC and the printed vascular phantoms are able to withstand 863K cycles over 10 days. Further, their suitability for ultrasonic imaging is demonstrated. Via B‐mode imaging, it is found that the vessel strains under a pulsatile flow are 11.7 ± 1.0% and 6.5 ± 1.5% for PVAGMA2/CNC and PVAGMA4/CNC vessels, respectively, perfectly matching the behaviors of healthy and atherosclerotic arteries. It exemplifies that the ink materials and printing strategy can have broad applications in biomedical research, especially for the fabrication of complex elastic tissue phantoms.

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“…PVA‐GMA was prepared according to the procedure as reported previously . Briefly, 5.0 g PVA was dissolved in 100 mL dimethyl sulfoxide (DMSO).…”

Section: Methodsmentioning

confidence: 99%

Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion

Zhou

Dong

Liang

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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Poly(vinyl alcohol) (PVA) hydrogels with high water content, good load‐bearing property, low frictional behavior as well as excellent biocompatibility have been considered as promising cartilage replacement materials. However, the lack of sufficient mechanical properties and cell adhesion are two critical barriers for their application as cartilage substitutes. To address these problems, herein, methacrylated PVA with low degree of substitution of methacryloyl group has been synthesized first. Then, methacrylated PVA‐glycidyl methacrylate/hydroxyapatite (PVA‐GMA/Hap) nanocomposite hydrogels have been developed by the photopolymerization approach subsequently. Markedly, both pure PVA‐GMA hydrogel and PVA‐GMA/Hap nanocomposite hydrogels exhibit excellent performance in compressive tests, and they are undamaged during compressive stress–strain tests. Moreover, compared to pure PVA‐GMA hydrogels, 8.5‐fold, 7.4‐fold, and 14.2‐fold increase in fracture stress, Young's modulus and toughness, respectively, can be obtained for PVA‐GMA/Hap nanocomposite hydrogels with 10 wt % Hap nanoparticles. These enhancements can be ascribed to the intrinsic property of PVA‐GMA and strong hydrogen bonding interactions between PVA‐GMA chain and Hap nanoparticles. More interestingly, significant improvement in the cell adhesion can also be successfully achieved by incorporation of Hap nanoparticles. These biocompatible nanocomposite hydrogels have great potential to be used as cartilage substitutes. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1882–1889

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Photocrosslinked Poly(vinyl alcohol) Nanofibrous Scaffolds

Cited by 5 publications

References 31 publications

High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion

High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion

Embedded 3D Printing of Ultrasound‐Compatible Arterial Phantoms with Biomimetic Elasticity

Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion

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