Photocurable O-carboxymethyl chitosan derivatives for biomedical applications: Synthesis, in vitro biocompatibility, and their wound healing effects

Na, Ha-Na; Park, Shin‐Hye; Kim, Kwang Il; Kim, Mi Kyung; Son, Tae‐Il

doi:10.1007/s13233-012-0167-2

Cited by 15 publications

(8 citation statements)

References 42 publications

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“…Synthesis of furan-based chitosan compounds: oligosaccharides and polysaccharides Epoxy amine reactions are often used for chitosan functionalisation. Reaction involving furfuryl glycidyl ether (FGE) and carboxymethyl chitosan has been described by Na et al(Na et al, 2012), who confirmed that the reaction occurred on the free amines that are more nucleophiles than alcohol groups of chitosan in the reaction condition (aqueous solution pH 11, 60°C, 48 h). This simple reaction was a one step-procedure as opposed to previous works using furfural and boric reducing agents to perform reductive amination (Montiel-Herrera et al, 2015) , (Guaresti et al, 2018) (Erreur !…”

Section: 2mentioning

confidence: 85%

Diels-Alder-Chitosan based dissociative covalent adaptable networks

Chapelle

Quienne

Bonneaud

et al. 2021

Carbohydrate Polymers

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Four different films were prepared from chitosan modified with furfuryl glycidyl ether (FG) by Diels Alder reaction with different maleimide-based cross linker. At first, a preliminary study led to structural identification and better understanding of the reaction. For the first time, Diels-Alder and retro Diels-Alder reactions were evidenced by NMR spectroscopy and DSC on chitosan based systems. Then, chitosan of 30,000 g/mol and 150,000 g/mol were modified by FG with 20% substitution degree (DS). The resulting products were then crosslinked with bis and trimaleimide cross-linkers to produce films possessing interesting mechanical properties. For the first time for chitosan-based films, DMA measurement highlighted retro Diels-Alder between 110 and 130°C. Film also showed interesting hydrophobicity and fat absorption. They also exhibited resistance in acidic media whereas crude chitosan films were destroyed.

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Section: 2mentioning

confidence: 85%

Diels-Alder-Chitosan based dissociative covalent adaptable networks

Chapelle

Quienne

Bonneaud

et al. 2021

Carbohydrate Polymers

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“…Owing to the high reactivity of furan derivatives, the synthesis of high-added value polymers is expected. Some examples of bio-based polymers such as DNA [415], gelatin [416], chitosan [417,418], alginate [419,420], and hyaluronic acid [421] have been previously described and are mainly used for tissue engineering applications [422], wound healing dressings [418,419,423], bio-sealant [412], antiadhesion material [416,420], regenerative medicine [424,425] and as cell laden hydrogel for 3D bioprinting [422,426].…”

Section: From Furan Derivativesmentioning

confidence: 99%

Bio-sourced monomers and cationic photopolymerization–The green combination towards eco-friendly and non-toxic materials

Pierau

Elian

Akimoto

et al. 2022

Progress in Polymer Science

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“…Na et al . () modified water‐soluble O ‐carboxymethyl chitosan derivatives with furfuryl glycidyl ether (O‐CMC/FGE); an in vitro cell viability test revealed a lack of cytotoxicity of O‐CMC/FGE against mouse 3T3 fibroblasts. O‐CMC/FGE also displayed wound‐healing effects in an in vivo animal experiment using a burn wound model.…”

Section: Introductionmentioning

confidence: 99%

Acceleration of skin regeneration in full-thickness burns by incorporation of bFGF-loaded alginate microspheres into a CMCS-PVA hydrogel

Liu

Huang

Lan³

et al. 2015

J Tissue Eng Regen Med

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Two important issues in skin tissue engineering are the vascularization and regeneration of the dermis. Basic fibroblast growth factor (bFGF) is known to promote angiogenesis and accelerate wound healing. Direct delivery of bFGF to the wound area, however, would lead to a loss of bioactivity. To this end, bFGF-loaded alginate microspheres (Ms) were fabricated and incorporated into carboxymethyl chitosan (CMCS)-poly(vinyl alcohol) (PVA) to form a composite hydrogel. Scanning electron microscopy (SEM) results indicated that the incorporation of Ms does not significantly affect the inner structure of CMCS-PVA. In an in vitro study, the release of bFGF from Ms-CMCS-PVA in a sustained manner retained higher bioactivity over a 2-week period. Full-thickness burn wounds were created in the dorsal area of rats for in vivo evaluation of skin regeneration treated with CMCS-PVA hydrogel, with and without bFGF. Compared with the control, CMCS-PVA and bFGF-CMCS-PVA groups, the bFGF/Ms-CMCS-PVA group revealed significantly faster wound recovery rates, with re-epithelialization and regeneration of the dermis. Moreover, the bFGF/Ms-CMCS-PVA group had the highest density of newly formed and mature blood vessels during the 2 mweek treatment period. The ability of the bFGF/Ms-CMCS-PVA hydrogel to accelerate wound healing in a full-thickness burn model suggests its potential for use in dermal tissue regeneration. Copyright © 2015 John Wiley & Sons, Ltd.

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Photocurable O-carboxymethyl chitosan derivatives for biomedical applications: Synthesis, in vitro biocompatibility, and their wound healing effects

Cited by 15 publications

References 42 publications

Diels-Alder-Chitosan based dissociative covalent adaptable networks

Diels-Alder-Chitosan based dissociative covalent adaptable networks

Bio-sourced monomers and cationic photopolymerization–The green combination towards eco-friendly and non-toxic materials

Acceleration of skin regeneration in full-thickness burns by incorporation of bFGF-loaded alginate microspheres into a CMCS-PVA hydrogel

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