Photocytotoxic cancer cell-targeting platinum(<scp>ii</scp>) complexes of glucose-appended curcumin and biotinylated 1,10-phenanthroline

Upadhyay, Aarti; Gautam, Srishti; Ramu, Vanitha; Kondaiah, Paturu; Chakravarty, Akhil R.

doi:10.1039/c9dt03490k

Cited by 33 publications

(27 citation statements)

References 76 publications

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“…Platinum-curcumin is another complex which has shown phototoxic and apoptosisinducing effects in cancer cells. This complex was found to induce cellular ROS and further apoptotic cell death under visible light [67,68]. Furthermore, this complex was found to synergistically enhance the chemotherapeutic effect of drugs and to sensitize cisplatin-resistant A549/DDP cells [69].…”

Section: Cancermentioning

confidence: 99%

“…Along with cellular uptake, this metal complex profoundly influences the distribution and release mechanism of curcumin [112]. Moreover, platinum-curcumin complexes showed stability over a study period of 48 h [68]. Additionally, platinum-based nanoparticle-curcumin complexes have been shown to greatly improve the solubility as well as stability of curcumin [69].…”

Section: Solubility Stability and Cellular Uptake Of Metal-curcumin Complexesmentioning

confidence: 99%

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Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

Prasad

DuBourdieu²,

Srivastava³

et al. 2021

IJMS

128

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Curcumin, an active component of the rhizome turmeric, has gained much attention as a plant-based compound with pleiotropic pharmacological properties. It possesses anti-inflammatory, antioxidant, hypoglycemic, antimicrobial, neuroprotective, and immunomodulatory activities. However, the health-promoting utility of curcumin is constrained due to its hydrophobic nature, water insolubility, poor bioavailability, rapid metabolism, and systemic elimination. Therefore, an innovative stride was taken, and complexes of metals with curcumin have been synthesized. Curcumin usually reacts with metals through the β-diketone moiety to generate metal–curcumin complexes. It is well established that curcumin strongly chelates several metal ions, including boron, cobalt, copper, gallium, gadolinium, gold, lanthanum, manganese, nickel, iron, palladium, platinum, ruthenium, silver, vanadium, and zinc. In this review, the pharmacological, chemopreventive, and therapeutic activities of metal–curcumin complexes are discussed. Metal–curcumin complexes increase the solubility, cellular uptake, and bioavailability and improve the antioxidant, anti-inflammatory, antimicrobial, and antiviral effects of curcumin. Metal–curcumin complexes have also demonstrated efficacy against various chronic diseases, including cancer, arthritis, osteoporosis, and neurological disorders such as Alzheimer’s disease. These biological activities of metal–curcumin complexes were associated with the modulation of inflammatory mediators, transcription factors, protein kinases, antiapoptotic proteins, lipid peroxidation, and antioxidant enzymes. In addition, metal–curcumin complexes have shown usefulness in biological imaging and radioimaging. The future use of metal–curcumin complexes may represent a new approach in the prevention and treatment of chronic diseases.

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Section: Cancermentioning

confidence: 99%

Section: Solubility Stability and Cellular Uptake Of Metal-curcumin Complexesmentioning

confidence: 99%

Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

Prasad

DuBourdieu²,

Srivastava³

et al. 2021

IJMS

128

View full text Add to dashboard Cite

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“…27,28 In addition, the red and green light-active BODIPY-based platinum( ii ) complexes with different molecular designs reported earlier by us had catecholate or other O,O-donor ligands lacking similarity to the present complexes. 29–32 The review article of Guo and co-workers highlights the recent advancements in monofunctional platinum( ii ) chemistry. 33…”

Section: Introductionmentioning

confidence: 99%

BODIPY–dipicolylamine complexes of platinum(ii): X-ray structure, cellular imaging and organelle-specific near-IR light type-II PDT

et al. 2022

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“…The improvement of the anticancer performance of metal-based agents is an important task of modern chemistry . Among the numerous strategies aimed at enhancing both activity and selectivity of these molecules, conjugation with biologically active molecular fragments targeting tumor cells is very promising. − In this context, our group has recently investigated Pt(II) complexes in 18 e– trigonal bipyramidal geometry ( tbp ) containing a sugar-based axial ligand ( 1 in Figure ). − …”

Section: Introductionmentioning

confidence: 99%

Pt(II) versus Pt(IV) in Carbene Glycoconjugate Antitumor Agents: Minimal Structural Variations and Great Performance Changes

et al. 2020

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Octahedral Pt(IV) complexes ( 2Pt–R ) containing a glycoconjugate carbene ligand were prepared and fully characterized. These complexes are structural analogues to the trigonal bipyramidal Pt(II) species ( 1Pt–R ) recently described. Thus, an unprecedented direct comparison between the biological properties of Pt compounds with different oxidation states and almost indistinguishable structural features was performed. The stability profile of the novel Pt(IV) compounds in reference solvents was determined and compared to that of the analogous Pt(II) complexes. The uptake and antiproliferative activities of 2Pt–R and 1Pt–R were evaluated on the same panel of cell lines. DNA and protein binding properties were assessed using human serum albumin, the model protein hen egg white lysozyme, and double stranded DNA model systems by a variety of experimental techniques, including UV–vis absorption spectroscopy, fluorescence, circular dichroism, and electrospray ionization mass spectrometry. Although the compounds present similar structures, their in-solution stability, cellular uptake, and DNA binding properties are diverse. These differences may represent the basis of their different cytotoxicity and biological activity.

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Photocytotoxic cancer cell-targeting platinum(ii) complexes of glucose-appended curcumin and biotinylated 1,10-phenanthroline

Abstract: Mixed-ligand platinum(ii) complexes of curcumin and functionalized 1,10-phenanthroline bases showed targeted photocytotoxic activity in cancer cells with apoptotic cell death.

Cited by 33 publications

References 76 publications

Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

BODIPY–dipicolylamine complexes of platinum(ii): X-ray structure, cellular imaging and organelle-specific near-IR light type-II PDT

Pt(II) versus Pt(IV) in Carbene Glycoconjugate Antitumor Agents: Minimal Structural Variations and Great Performance Changes

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