Photodiagnosis and treatment of condyloma acuminatum using 5-aminolevulinic acid and homemade devices

Inada, Natália Mayumi; Costa, Mardoqueu Martins da; Guimarães, O.C.C.; Ribeiro, Elizeu da Silva; Kurachi, Cristina; Quintana, Silvana Maria; Lombardi, Wellington; Bagnato, Vanderlei Salvador

doi:10.1016/j.pdpdt.2011.09.001

Cited by 43 publications

(25 citation statements)

References 24 publications

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“…This occurs due to the cell changes in BCC as suggested by Martin et al [13]. Differences in the PpIX intensity may also be due to cell type from different tissues as observed by Inada et al [25]. PpIX production did not differ significantly between different lesions of the same tissue of BCC, squamous cell carcinoma (SCC) and psoriasis [26].…”

Section: Discussionmentioning

confidence: 83%

Fluorescence guided PDT for optimization of the outcome of skin cancer treatment

et al. 2015

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The photodynamic therapy (PDT) is an alternative technique that can be used for treating superficial basal cell carcinoma (sBCC), Bowen's disease and actinic keratosis with highefficiency. The objective of this study is to present a method where fluorescence imaging together with for PDT as a monitoring guidance in real time. Confirming that the lesion is well prepared and the photosensitizer shows a homogenous distribution, the outcome after few PDT sessions will be more predictable and the recurrence is minimized. Our proposition in this study is use the widefield fluorescence imaging to evaluate the PDT protocol in situ and in real time for each lesion. This evaluation procedure is performed in two steps: first with the monitoring of the production of protoporphyrin IX (PpIX) induced by methyl aminolevulinate (MAL), a derivative of 5-aminolevulinic acid (ALA) and second with the detection of PpIX photobleaching after illumination. The fluorescence images provide information correlated with distinct clinical features and with the treatment outcome. Eight BCC lesions are presented and discussed in this study. Different fluorescence patterns of PpIX production and photobleaching could be correlated with the treatment response. The presented results show the potential of using widefield fluorescence imaging as a guidance tool to customized PDT. This procedure is being incorporated to the main PDT skin cancer protocol applied in Brazil with an excellent outcome.

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Section: Discussionmentioning

confidence: 83%

Fluorescence guided PDT for optimization of the outcome of skin cancer treatment

et al. 2015

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“…L'intérêt de la PDT dans le traitement des verrues ne se limite pas aux lésions cutanées secondaires aux HPV mais aussi aux verrues génitales ou condylomes. Les résultats sont intéressants avec une meilleure réponse cosmétique par rapport aux thérapeutiques conventionnelles avec moins de risque de récidive [9]. …”

Section: Discussionunclassified

Verrue géante et récalcitrante: succès d’un traitement par photothérapie dynamique

Meziane¹,

Bettioui²,

Krich³

et al. 2013

Pan Afr Med J

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La photothérapie dynamique (PDT) utilisant l'acide methyl ester amino-levulinique est essentiellement utilisée dans les pathologies cutanées cancéreuses et précancéreuses. Son application au traitement des verrues est de description récente. Nous rapportons le cas d'un patient immunocompétent ayant une verrue géante et récalcitrante de la main droite traitée avec succès par la PDT, et discutons les difficultés de la prise en charge de ces verrues et l'intérêt de ce traitement dans l'obtention d'une bonne réponse thérapeutique et cosmétique avec peu de risque de récidive.

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“…This therapy is based on three basic elements: the presence of a photosensitizer, a drug that absorbs light to trigger a series of chemical reactions; light at an appropriate wavelength, and the molecular oxygen present in the tissue to be treated, which reacts with the activated drug resulting in reactive oxygen species that are capable of inducing the cellular tissue necrosis, with subsequent re-epithelialization [18] . Our research group has a long experience in clinical trials using PDT for the treatment of non-melanoma skin cancer [19] , onychomycosis [20] , condyloma and cervical intraepithelial neoplasia [21] . PDT allows treatment of a large extension of skin, achieving both subclinical and clinical lesion, less aggressively and more efficiently, with good aesthetic outcome.…”

Section: Introductionmentioning

confidence: 99%

Clinical Protocol Standardized in a Public Health System Using a Prototype for Actinic Keratosis and Field Cancerization Treatment

Sálvio¹,

Oliveira²,

Ramirez³

et al. 2016

Journal of Tumor

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Photodiagnosis and treatment of condyloma acuminatum using 5-aminolevulinic acid and homemade devices

Cited by 43 publications

References 24 publications

Fluorescence guided PDT for optimization of the outcome of skin cancer treatment

Fluorescence guided PDT for optimization of the outcome of skin cancer treatment

Verrue géante et récalcitrante: succès d’un traitement par photothérapie dynamique

Clinical Protocol Standardized in a Public Health System Using a Prototype for Actinic Keratosis and Field Cancerization Treatment

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