We thoroughly study the photo-disintegration of 4 He on the cosmic microwave background using the most recent cross-section data both from the inclusive measurement observing the analog of the giant dipole resonance in 4 He through the charge-exchange spin-flip 4 He ( 7 Li, 7 Be) reaction and from measurements of exclusive two-body and three-body processes: 4 He (γ, p) 3 H, 4 He (γ, n) 3 He, and 4 He (γ, pn) 2 H. We show that the present-day (redshift z = 0) mean free path of ultra-relativistic (Lorentz factor ∼ 10 10 ) helium nuclei increases by more that 15% with respect to previous estimates adopted as benchmarks for Monte Carlo simulation codes of ultrahigh-energy cosmic ray propagation. This implies that the physical survival probability of 4 He nuclei would be larger than predicted by existing event generators. For example, for E ∼ 10 10.8 GeV and a propagation distance of 3.5 Mpc, the 4 He intensity would be 35% larger than the output of CRPropa 3 program and 42% larger than the output of SimProp v2r4 program. We provide new parametrizations for the two-body and three-body photodisintegration cross-sections of 4 He, 3 He, tritium, and deuterium.