Photodynamic action of methylene blue subjected to aromatic-aromatic interactions with poly(sodium 4-styrenesulfonate) in solution and supported in solid, highly porous alginate sponges

Coronel, Alejandra; Catalán‐Toledo, José; Fernández-Jaramillo, Heriberto; Godoy-Martínez, Patricio; Flores, Mario E.; Moreno‐Villoslada, Ignacio

doi:10.1016/j.dyepig.2017.08.042

Cited by 20 publications

(5 citation statements)

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“…Among all the photosensitizers, methylene blue (MB) is a desirable and water-soluble PS that can undergo both types of PDT mechanisms and, through the Type II route, it is able to generate a high ratio of singlet oxygen (FD B 0.5), with strong electrophilic activation of the oxidizing electron-rich double bonds in biological molecules and macromolecules. 4 It is also an FDA approved medicine and has been extensively used as a diagnostic agent or histological dye in clinical applications. [5][6][7] However, it can easily selfaggregate, which leads to the formation of dimers, trimers and H-aggregates.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of methylene blue into mesoporous silica nanoparticles for singlet oxygen generation

Pelluau

Monnereau

et al. 2023

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

Incorporation of methylene blue into mesoporous silica nanoparticles for singlet oxygen generation

Pelluau

Monnereau

et al. 2023

New J. Chem.

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“…As shown in the videos (video S1, video S2), the microfibers were rapidly hydrated, and the material were dispersed in small pieces into the medium. Materials with similar behavior when exposed to biorelevant media have been proposed for in vitro/in vivo testing for wound healing purposes [32,34,38] and/or to be enriched with active molecules for therapeutic purposes [39,40,41]. Furthermore, other interesting characterizations regarding the interplay between cells and solid materials and obtaining the stiffness have been published.…”

Section: Resultsmentioning

confidence: 99%

Ionic Nanocomplexes of Hyaluronic Acid and Polyarginine to Form Solid Materials: A Green Methodology to Obtain Sponges with Biomedical Potential

et al. 2019

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We report on the design, development, characterization, and a preliminary cellular evaluation of a novel solid material. This material is composed of low-molecular-weight hyaluronic acid (LMWHA) and polyarginine (PArg), which generate aqueous ionic nanocomplexes (INC) that are then freeze-dried to create the final product. Different ratios of LMWHA/PArg were selected to elaborate INC, the size and zeta potential of which ranged from 100 to 200 nm and +25 to −43 mV, respectively. Turbidimetry and nanoparticle concentration analyses demonstrated the high capacity of the INC to interact with increasing concentrations of LMWHA, improving the yield of production of the nanostructures. Interestingly, once the selected formulations of INC were freeze-dried, only those comprising a larger excess of LMWHA could form reproducible sponge formulations, as seen with the naked eye. This optical behavior was consistent with the scanning transmission electron microscopy (STEM) images, which showed a tendency of the particles to agglomerate when an excess of LMWHA was present. Mechanical characterization evidenced low stiffness in the materials, attributed to the low density and high porosity. A preliminary cellular evaluation in a fibroblast cell line (RMF-EG) evidenced the concentration range where swollen formulations did not affect cell proliferation (93–464 µM) at 24, 48, or 72 h. Considering that the reproducible sponge formulations were elaborated following inexpensive and non-contaminant methods and comprised bioactive components, we postulate them with potential for biomedical purposes. Additionally, this systematic study provides important information to design reproducible porous solid materials using ionic nanocomplexes.

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“…The light source was placed closely behind the test tube (Figure D in Supplementary material). Numerical values of the RGB additive color model were taken from the mid of the images using HTML Color Picker (2020). Samples for interference tests consisted of 0.2 µmole of NMB, 0.06 mg of refined iota carrageenan Kerry, varying quantities of examined food additive and water up to 4 mL.…”

Section: Spectrophotometric and Smartphone-based Colorimetric Measurementsmentioning

confidence: 99%

Determination of carrageenan in jellies with new methylene blue dye using spectrophotometry, smartphone-based colorimetry and spectrophotometric titration

et al. 2021

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Carrageenan is a seaweed polysaccharide widely used as a food gelling and thickening agent. The New Methylene Blue dye was tested as an analytical reagent for the quantification of carrageenan in commercial jelly samples. The main spectral peaks of the dye decrease with increasing carrageenan-to-dye molar ratio up to 1. Three analytical procedures were tested: (i) spectrophotometric measurement at 590 nm, (ii) smartphone-based color measurement within the RGB color model and (iii) spectrophotometric titration at 625 nm. All the procedures provide straight calibration lines. Spectrophotometry provides better linearity as compared to smartphone-based colorimetry. Range of determination is dependent on type and purity of carrageenan. The spectrophotometric titration procedure provides lower values of limit of determination due to longer optical path used. Typical food additives used in jelly deserts do not interfere significantly with the proposed analytical approach.

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Photodynamic action of methylene blue subjected to aromatic-aromatic interactions with poly(sodium 4-styrenesulfonate) in solution and supported in solid, highly porous alginate sponges

Cited by 20 publications

References 58 publications

Incorporation of methylene blue into mesoporous silica nanoparticles for singlet oxygen generation

Incorporation of methylene blue into mesoporous silica nanoparticles for singlet oxygen generation

Ionic Nanocomplexes of Hyaluronic Acid and Polyarginine to Form Solid Materials: A Green Methodology to Obtain Sponges with Biomedical Potential

Determination of carrageenan in jellies with new methylene blue dye using spectrophotometry, smartphone-based colorimetry and spectrophotometric titration

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