Photodynamic and photothermal co-driven CO-enhanced multi-mode synergistic antibacterial nanoplatform to effectively fight against biofilm infections

Cai, Xiaojun; Tian, Jiang; Zhu, Jingwu; Chen, Junpeng; Li, Lin; Yang, Chao; Chen, Jiale; Chen, Dongfan

doi:10.1016/j.cej.2021.131919

Cited by 91 publications

(57 citation statements)

References 78 publications

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“…Figure 5 B plotted the colony formation units (CFU) counts of S. aureus and E. coli upon different challenges in presence of light irradiation. Compared with the control group, the biofilm CFU of S. aureus and E. coli in POS-UCNPs group was not significantly reduced (p > 0.05), indicating the limited anti-biofilm capacity of CO. Interestingly, Cai et al considered CO gas exhibited antibacterial activity 50 . The POS-UCNPs group with light irradiation had no therapeutic effect in the present study, because the produced CO concentration was not high enough to destroy bacterial biofilms 51 .…”

Section: Resultsmentioning

confidence: 99%

Antibacterial PDT nanoplatform capable of releasing therapeutic gas for synergistic and enhanced treatment against deep infections

et al. 2022

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Antibacterial photodynamic therapy (aPDT) has emerged as an attractive treatment option for efficient removal of pathogenic bacteria. However, aPDT in deep tissue will encounter difficulties such as limited light penetration depth, insufficient oxygen (O 2 ) supply and inability to eliminate inflammation introduced by bacteria, which hinders its clinical application. Herein, the near infrared (NIR) strategy of simultaneously generating O 2 and CO was developed for aPDT based antibacterial therapy and mitigation of deep infection inflammation. Methods: We prepared NIR-mediated multifunctional aPDT nanoplatform (POS-UCNPs/ICG) producing therapeutic gas of O 2 and CO. The CO, O 2 and ROS generation of the nanoplatform were characterized by dye probes, respectively. The antibacterial activity and anti-inflammation of POS-UCNPs/ICG were demonstrated in vitro and in vivo . In addition, the therapeutic effects in vivo were serially analyzed by immunofluorescence staining, Masson's staining, hematoxylin and eosin staining, colony formation units (CFU) and so on. Results: NIR-mediated multifunctional aPDT nanoplatform was realized by combining the up-conversion nanoparticles (UCNPs) and partially oxidized SnS 2 (POS) nanosheets (NSs) as well as indocyanine green (ICG). Using a single 808 nm light, aPDT can be achieved via ICG molecules, meanwhile, O 2 /CO can be generated by POS NSs through upconversion light excitation. During the aPDT process, O 2 can enhance aPDT, while CO can regulate inflammation through the PI3K/NF-κB pathway. Therefore, POS-UCNPs/ICG groups had a highest percentage of healing area up to 91.55±1.26% in mouse abscess model. Conclusion: Due to enhanced aPDT and anti-inflammatory collaborative therapy, the POS-UCNPs/ICG composites showed remarkably accelerated recovery in animal abscess models. Such NIR light responsive nanoplatform with optimized antibacterial capacity and immunomodulatory functions is promising for clinical therapeutics of bacteria-induced infections.

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Section: Resultsmentioning

confidence: 99%

Antibacterial PDT nanoplatform capable of releasing therapeutic gas for synergistic and enhanced treatment against deep infections

et al. 2022

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“…More importantly, it has enabled combination therapies involving PDT that successfully augment its bacterial and biofilm destruction mechanisms in many ways. Nanoconjugate-mediated combination with several known antibiotics such as vancomycin, minocycline, and cefepime have demonstrated the power of incorporating these drugs with the photodynamic photosensitizer in one nanoconjugate [ 107 , 108 , 109 , 110 , 111 , 112 ] while plasmonic nanoparticle-mediated combination with PTT [ 113 , 114 , 115 , 116 , 119 , 120 , 121 , 122 , 123 ] showed synergistic improvements in bacterial and biofilm eradication. Given that different antibiotic drugs have different mechanism and targets, the data presented by Pérez-Laguna et al (2021) on the use of more than one antibiotic drug in combination with PDT suggests that more research is needed to evaluate synergism and additivity [ 21 ].…”

Section: General Discussion and Future Perspectivesmentioning

confidence: 99%

“…The nanomaterial-mediated photothermal-aPDT methodology has been modified by numerous researchers to overcome many of its limitations. For example, an indocyanine green and manganese pentacarbonyl bromide-doped dendrimer-based nanogel generated sufficient quantities of carbon monoxide to overcome collateral tissue damage and inflammation in the photothermal-photodynamic eradication of Escherichia coli and methicillin-resistant Staphylococcus aureus [ 115 ]. Environmentally responsive releases of chemotherapy drugs and photosensitizers endow these studies with high specificity.…”

Section: Combination With Photothermal Hyperthermia Therapymentioning

confidence: 99%

Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

Songca

Adjei

2022

IJMS

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Antimicrobial photodynamic therapy and allied photodynamic antimicrobial chemotherapy have shown remarkable activity against bacterial pathogens in both planktonic and biofilm forms. There has been little or no resistance development against antimicrobial photodynamic therapy. Furthermore, recent developments in therapies that involve antimicrobial photodynamic therapy in combination with photothermal hyperthermia therapy, magnetic hyperthermia therapy, antibiotic chemotherapy and cold atmospheric pressure plasma therapy have shown additive and synergistic enhancement of its efficacy. This paper reviews applications of antimicrobial photodynamic therapy and non-invasive combination therapies often used with it, including sonodynamic therapy and nanozyme enhanced photodynamic therapy. The antimicrobial and antibiofilm mechanisms are discussed. This review proposes that these technologies have a great potential to overcome the bacterial resistance associated with bacterial biofilm formation.

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“…89,90 (3) As we know, the bacterial biofilm formation is the main cause of refractory infection. 91 The extracellular matrix as the main component of biofilm mainly contains protein, lipopolysaccharide and extracellular DNA. Therefore, using nanozyme with DNase-like activity not only can prevent biofilm formation, but also can augment the bioactivity of conventional antibiotics by the degradation of extracellular matrixes.…”

Section: Antibacterial Mechanisms Of Nanozymesmentioning

confidence: 99%