Photodynamic and Photothermal Effects of Semiconducting and Metallic-Enriched Single-Walled Carbon Nanotubes

Murakami, Tatsuya; Nakatsuji, Hideaki; Inada, Mami; Matoba, Yoshinori; Umeyama, Tomokazu; Tsujimoto, Masahiko; Isoda, Seiji; Hashida, Mitsuru; Imahori, Hiroshi

doi:10.1021/ja3079972

Cited by 170 publications

(139 citation statements)

References 38 publications

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“…It should be noted that the single-CNT method is not limited to the reversible activation of protein function. The reversible mode becomes irreversible simply by extensive heating at >40°C, which inactivates most proteins irreversibly through thermal denaturation, as demonstrated for ablating cancer cells (Kam et al 2005;Biris et al 2009;Murakami et al 2012). Inoue et al (2015) used a constant concentration of oxygen Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Although a concrete mechanism of CNT toxicity is still open to discussion, the CNTinduced generation of reactive oxygen species (ROS) may be a key factor to induce DNA damage and protein modifications (Pacurari et al 2008;Liu et al 2011). CNT toxicity can be strongly enhanced by laser irradiation, which generates both heat and ROS to kill cancer cells (Kam et al 2005;Murakami et al 2012). In some biological applications, CNT toxicity can be minimized by reducing agglomerate CNT structures (Pauluhn 2010) and by processes that functionalize the CNT surface, such as the chemical formation of organometallic structures (Chen et al 1998;Cui et al 2004) or noncovalent coatings with phospholipid-polyethylene glycols or other amphiphilic surfactant molecules (Liu et al 2007).…”

Section: Cnt Toxicity In Biological Applicationsmentioning

confidence: 99%

“…In contrast to the low absorption of the NIR light by water, CNTs can effectively absorb NIR light (wavelength 1064 nm, power 1536 mW) to induce a local temperature rise of up to 172°C in mammalian tissue (Picou et al 2010). Continuous NIR irradiation (wavelength 808 nm, power 50-500 mW) on singlewalled CNTs effectively ablates cancer cells such as HeLa (Kam et al 2005) and human lung-cancer NCI-H460 cells (Murakami et al 2012 …”

Section: Laser-induced Heating Of Biomoleculesmentioning

confidence: 99%

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Local heating of molecular motors using single carbon nanotubes

Inoue

Ishijima

2016

Biophys Rev

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Temperature globally affects all chemical processes and biomolecules in living cells. Elevating the temperature of an entire cell accelerates so many biomolecular reactions simultaneously that it is difficult to distinguish the various mechanisms involved. The ability to localize temperature changes to the nanometer range within a cell could provide a powerful new tool for regulating biomolecular activity at the level of individual molecules. The search for a nanoheater for biological research has prompted experiments with carbon nanotubes (CNTs), which have the highest conductivity of any known material. The adsorption of skeletal muscle myosin molecules along the length of single multi-walled CNTs (~10 μm) has allowed researchers to observe the ATP-driven sliding of fluorescently labeled actin filaments. In one study, red-laser irradiation focused on one end of a myosin-coated CNT was used to heat myosin motors locally without directly heating the surrounding water; this laser irradiation instantly accelerated the actin-filament sliding speeds from~6 to~12 μm/s in a reversible manner, indicating a local, real-time heating of myosin motors by approximately Δ12 K. Calculation of heat transfer using the finite element method, based on the estimated temperature along a single CNT with a diameter of 170 nm, indicated a high thermal conductivity of~1540 Wmtion, consistent with values measured in vacuum in earlier studies. Temperature distribution indicated by half-decrease distances was~3660 nm along the length of the CNT and 250 nm perpendicular to the length. These results suggest that single-CNT-based heating at the nanometer-or micrometerrange could be used to regulate various biomolecules in many areas of biological, physical, and chemical research.

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Section: Discussionmentioning

confidence: 99%

Section: Cnt Toxicity In Biological Applicationsmentioning

confidence: 99%

Section: Laser-induced Heating Of Biomoleculesmentioning

confidence: 99%

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Local heating of molecular motors using single carbon nanotubes

Inoue

Ishijima

2016

Biophys Rev

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“…50 In the irradiation therapeutic window using laser parameters, as was applied during this study, the effect was mostly athermic with limited heat transfer (0.65°C).…”

mentioning

confidence: 90%

Photodynamic ability of silver nanoparticles in inducing cytotoxic effects in breast and lung cancer cell lines

Elhussein¹,

Harith²,

Abrahamse³

et al. 2014

IJN

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“…Another research group also analyzed the photodynamics of (6,5)-SWNTs suspended in H 2 O with another polymer, to determine the triplet state lifetime (30±10 µs) and the quantum yield of triplet formation (5±2%). 64) Our group has revealed that semiconducting SWNTs of high purity are able to generate 1 O 2 and O 2 · − in H 2 O containing 1 wt% sodium deoxycholate under NIR illumination at 808 nm 65) (Fig. 8).…”

Section: Optical Properties Of Swntsmentioning

confidence: 99%

Photodynamic Action of Single-Walled Carbon Nanotubes

Murakami

2017

Chem. Pharm. Bull.

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Photodynamic therapy is achieved by the combination of photosensitizers, harmless visible or nearinfrared (NIR) light, and molecular oxygen (O 2 ). Photosensitizers transfer their absorbed light energy to O 2 to generate a major active species in photodynamic therapy, singlet oxygen. In this review, I will discuss the possibility of single-walled carbon nanotubes as NIR photosensitizers, while explaining the general photophysics and photochemistry underlying photodynamic therapy as well as summarizing recent advances in the purification technologies for single-walled carbon nanotubes to reduce their toxicity concerns.

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Photodynamic and Photothermal Effects of Semiconducting and Metallic-Enriched Single-Walled Carbon Nanotubes

Cited by 170 publications

References 38 publications

Local heating of molecular motors using single carbon nanotubes

Local heating of molecular motors using single carbon nanotubes

Photodynamic ability of silver nanoparticles in inducing cytotoxic effects in breast and lung cancer cell lines

Photodynamic Action of Single-Walled Carbon Nanotubes

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