Photodynamic cytotoxic and antibacterial evaluation of Tecoma stans and Narcissus tazetta mediated silver nanoparticles

Tariq, Hina; Rafi, Muhammad; Amirzada, Muhammad Imran; Muhammad, Syed Aun; Yameen, Muhammad Arfat; Mannan, Abdul; Ismail, Tariq; Shahzadi, Irum; Murtaza, Ghulam; Fatima, Nighat

doi:10.1016/j.arabjc.2021.103652

Cited by 11 publications

(13 citation statements)

References 22 publications

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“…This is the first report of the cytotoxic and anticancer potential of T. pallida extract and its biosynthesized silver nanoparticles ( Supplementary Figure S1 ). These findings are comparable to the previous reports that both plant extract and biosynthesized silver nanoparticles worked effectively ( Jeyaraj et al, 2013 ; Tariq et al, 2022 ). The biosynthesized TpAgNPs were also highly active; however, TpAgNP6 (5:10) sample was significantly ( p ≤ 0.05) more active with an IC 50 value of 81.5 ± 1.9 μg/ml in inhibiting cellular growth in comparison to all other nanoparticle samples and plant extract.…”

Section: Resultssupporting

confidence: 91%

Antioxidant, Cytotoxic, and Antimicrobial Potential of Silver Nanoparticles Synthesized using Tradescantia pallida Extract

Shahzadi

Shah

et al. 2022

Front. Bioeng. Biotechnol.

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Silver nanoparticles have received much attention, due to their wide range of biological applications as an alternative therapy for disease conditions utilizing the nanobiotechnology domain for synthesis. The current study was performed to examine the antioxidant, anticancer, antibacterial, and antifungal potential of biosynthesized silver nanoparticles (TpAgNPs) using plant extract. The TpAgNPs were produced by reacting the Tradescantia pallida extract and AgNO3 solution in nine various concentration ratios subjected to bioactivities profiling. According to the current findings, plant extract comprising phenolics, flavonoids, and especially anthocyanins played a critical role in the production of TpAgNPs. UV–visible spectroscopy also validated the TpAgNP formation in the peak range of 401–441 nm. Further, the silver ion stabilization by phytochemicals, face-centered cubic structure, crystal size, and spherical morphology of TpAgNPs were analyzed by FTIR, XRD, and SEM. Among all TpAgNPs, the biosynthesized TpAgNP6 with a medium concentration ratio (5:10) and the plant extract had effective antioxidant potentials of 77.2 ± 1.0% and 45.1 ± 0.5% free radical scavenging activity, respectively. The cytotoxic activity of TpAgNP6 in comparison to plant extract for the rhabdomyosarcoma cell line was significantly the lowest with IC50 values of 81.5 ± 1.9 and 90.59 ± 1.6 μg/ml and cell viability % of 24.3 ± 1.62 and 27.4 ± 1.05, respectively. The antibacterial and antifungal results of TpAgNPs revealed significant improvement in comparison to plant extract, i.e., minimum inhibition concentration (MIC) 64 μg/ml against Gram-negative Pseudomonas aeruginosa while, in the case of antifungal assay, TpAgNP6 was active against Candida parapsilosis. These TpAgNPs play a crucial role in determining the therapeutic potential of T. pallida due to their biological efficacy.

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Section: Resultssupporting

confidence: 91%

Antioxidant, Cytotoxic, and Antimicrobial Potential of Silver Nanoparticles Synthesized using Tradescantia pallida Extract

Shahzadi

Shah

et al. 2022

Front. Bioeng. Biotechnol.

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“…The changes in cell morphology were observed from a minimal dose of 5 μL/mL under a phase-contrast inverted microscope (20 × magnification). The findings are comparable to the previous reports stating that biosynthesized silver nanoparticles work effectively (Tariq et al 2022). This activity might be due to the synergetic impact of AgNPs and bioactive compounds like biosurfactants which adhere to the nanoparticles' surfaces.…”

Section: The Cytotoxicity Of Bio-agnpssupporting

confidence: 87%

Archives of Environmental Protection

Chojniak-Gronek,

Jałowiecki,

Płaza

2022

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The present study is focused on the evaluation of bioeffects of silver nanoparticles (AgNPs) synthesized by Bacillus subtilis strain I'-1a, the producer of iturin A lipopeptide biosurfactant. The following properties of biologically synthesized silver nanoparticles (bio-AgNPs) were evaluated: in vitro cytotoxicity, antioxidant properties, and metabolic activities of mammalian cells. As a control, chemically synthesized silver nanoparticles (chem-AgNPs) were used. In vitro, antioxidant activity of bio-AgNPs showed a significant effect on the scavenging of free radicals. Bio-AgNPs can be potent natural antioxidants and can be essential for health preservation against oxidative stress-related degenerative diseases, such as cancer. The cell viability of human skin fibroblasts NHDF was remarkably inhibited in the presence of both AgNPs. However, bio-AgNPs were more active than chem-AgNPs. In our experiment, microarrays PM-M1-PM-M4 were used to evaluate the growth of NHDF fibroblast cells in the presence of bio-AgNPs and chem-AgNPs. The NHDF fibroblast cells were more active in the presence of bio-AgNPs than in chem-AgNPs. Probably, the presence of biosurfactant produced by Bacillus subtilis I'-1a significantly increased the stability of biogenic AgNPs and enhanced their biological activities and specific interaction with human DNA. Furthermore, the evaluated biological activities were enhanced for the biosurfactant-based AgNPs.

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“…The ornamental plants Tecoma stans ( T. stans ) and N. tazetta , perennial plants, were used as reducing agents for the conversion of Ag(I) to Ag (0), with a particle size of above 20 nm. The change in particle size of nanosilver ions has been reflected in the optoelectronic and sensing properties of PDT . Pectin, a heteropolysaccharide found in fruits and plants, was utilized to upsurge the biocompatibility of the nanosilver ions and to advance ROS production and fluorescence to a higher level which is the mechanistic step of PDT …”

Section: Optical Sensing Applications Of Silver Nanoparticlementioning

confidence: 99%

Bioinspired Multifunctional Silver Nanoparticles for Optical Sensing Applications: A Sustainable Approach

Singh,

Natarajan,

Pandey

2023

ACS Appl. Bio Mater.

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Silver nanoparticles developed via biosynthesis are the most fascinating nanosized particles and encompassed with excellent physicochemical properties. The bioinspired nanoparticles with different shapes and sizes have attracted huge attention due to their stability, low cost, environmental friendliness, and use of less hazardous chemicals. This is an ideal method for synthesizing a range of nanosized metal particles from plants and biomolecules. Optical biosensors are progressively being fabricated for the attainment of sustainability by using opportunities offered by nanotechnology. This review focuses mainly on tuning the optical properties of the metal nanoparticles for optical sensing to explore the importance and applications of bioinspired silver nanoparticles. Further, this review deliberates the role of bioinspired silver nanoparticles (Ag NPs) in biomedical, agricultural, environmental, and energy applications. Profound insight into the antimicrobial properties of these nanoparticles is also appreciated. Tailor-made bioinspired nanoparticles with effectuating characteristics can unsurprisingly target tumor cells and distribute enwrapped payloads intensively. Existing challenges and prospects of bioinspired Ag NPs are also summarized. This review is expected to deliver perceptions about the progress of the next generation of bioinspired Ag NPs and their outstanding performances in various fields by promoting sustainable practices for fabricating optical sensing devices.

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Photodynamic cytotoxic and antibacterial evaluation of Tecoma stans and Narcissus tazetta mediated silver nanoparticles

Cited by 11 publications

References 22 publications

Antioxidant, Cytotoxic, and Antimicrobial Potential of Silver Nanoparticles Synthesized using Tradescantia pallida Extract

Antioxidant, Cytotoxic, and Antimicrobial Potential of Silver Nanoparticles Synthesized using Tradescantia pallida Extract

Archives of Environmental Protection

Bioinspired Multifunctional Silver Nanoparticles for Optical Sensing Applications: A Sustainable Approach

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