Photodynamic diagnosis with 5‐aminolevulinic acid for intraoperative detection of peritoneal metastases of ovarian cancer: A feasibility and dose finding study

Hillemanns, Peter; Wimberger, Pauline; Reif, J.; Stepp, Herbert; Klapdor, Rüdiger

doi:10.1002/lsm.22613

Cited by 26 publications

(31 citation statements)

References 36 publications

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“…Previous clinical studies have shown that 5-ALA PDD could detect peritoneal disseminated lesions from both gastric and ovarian cancers (20)(21)(22). Similarly, in the present study, it was possible to detect small disseminated lesions originating from biliary tract cancer.…”

Section: Discussionsupporting

confidence: 63%

5-Aminolevulinic-acid-mediated Photodynamic Diagnosis Enhances the Detection of Peritoneal Metastases in Biliary Tract Cancer in Mice

Kubota

Noji

Ebihara

et al. 2018

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Abstract. Background/Aim: Previous studies on the accuracy of 5-aminolevulinic-acid-mediated photodynamic diagnosis (5-ALABiliary cancers, such as perihilar cholangiocarcinoma, gallbladder carcinoma and intrahepatic cholangiocarcinoma, are one of the most difficult cancers to manage regarding staging and radical resection. Despite these facts, preoperative diagnosis, management, and operative strategies have improved. Major hepatectomy and vascular reconstructions for curative resection of biliary cancers are highly invasive surgeries associated with high morbidity and mortality, with a 5-year survival rate of approximately 40% (1-6).Biliary carcinoma exhibits multiple recurrence patterns with distant metastasis such as liver or peritoneal metastases being most common. Therefore, many patients already have small, minimally-invasive, occult liver or peritoneal metastasis before undergoing surgery (1, 7). Presently, modalities such as computed tomography and magnetic resonance imaging are inadequate for the detection of small occult lesions. Improved detection of small lesions could inform surgeons to avoid any unnecessary surgeries.The metabolite of the amino acid 5-aminolevulinic acid (5-ALA), termed protoporphyrin IX (PpIX) selectively accumulates in tumors. PpIX emits red fluorescence peaking at 635 nm under blue-violet light excitation of 400-410 nm (8). In clinical trials, Stummer et al. (9) first demonstrated the use of photodynamic diagnosis (PDD) using 5-ALA to diagnose malignant glioma, intraoperatively. Subsequently, 5-ALA PDD 905

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Section: Discussionsupporting

confidence: 63%

5-Aminolevulinic-acid-mediated Photodynamic Diagnosis Enhances the Detection of Peritoneal Metastases in Biliary Tract Cancer in Mice

Kubota

Noji

Ebihara

et al. 2018

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“…However, ALA is absorbed from peritoneal lymphatics and blood vessels, and then reaches PM tissue from the blood circulation [20]. Accordingly, ALA PDD was recommended to start 3 to 5 h after IP administration [20,26]. Higher dose of ALA can be administered intraperitoneally as compared with IV administration, because high dose IV administration of ALA may cause side effects.…”

Section: Clinical Application Of Ala Pdd To Detect Peritoneal Metamentioning

confidence: 99%

“…Maximum fluorescence in PM was found on 1 to 3 h after IV infusion of 100 mg/kg of ALA. Gahlen et al reported that fluorescence laparoscopy after IP photosensitization with ALA was a more reliable and effective method than IV photosensitization for the detection of small or occult PM [22]. As compared with IP administration, oral application is convenient and non-invasive [18,26]. …”

Section: Clinical Application Of Ala Pdd To Detect Peritoneal Metamentioning

confidence: 99%

Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)

Yonemura

Endo

Canbay³

et al. 2017

Cancers

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In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM.

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“…Photodynamic diagnosis very often enables the visualization of irregular lesion shapes more precisely than a classical white-light examination. 5,6 In the case of hyperkeratotic lesions, during PDD, the fluorescence of healthy background tissue is higher than the fluorescence of pathological lesions due to the thicker layer of the epithelium; thus, in these cases a negative image of the examined lesion is observed.…”

Section: Introductionmentioning

confidence: 99%

Application of fractal dimension analysis and photodynamic diagnosis in the case of differentiation between lichen planus and leukoplakia: A preliminary study

Jurczyszyn¹,

Kazubowska²,

Kubasiewicz−Ross³

et al. 2018

Adv Clin Exp Med

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Photodynamic diagnosis with 5‐aminolevulinic acid for intraoperative detection of peritoneal metastases of ovarian cancer: A feasibility and dose finding study

Cited by 26 publications

References 36 publications

5-Aminolevulinic-acid-mediated Photodynamic Diagnosis Enhances the Detection of Peritoneal Metastases in Biliary Tract Cancer in Mice

5-Aminolevulinic-acid-mediated Photodynamic Diagnosis Enhances the Detection of Peritoneal Metastases in Biliary Tract Cancer in Mice

Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)

Application of fractal dimension analysis and photodynamic diagnosis in the case of differentiation between lichen planus and leukoplakia: A preliminary study

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