Photodynamic Effect of a New Photosensitizer ATX-S10 on Corneal Neovascularization

Gohto, Yuko; Obana, Akira; Kaneda, Kenji; Miki, Tokuhiko

doi:10.1006/exer.1998.0527

Cited by 34 publications

(14 citation statements)

References 29 publications

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“…6,7 Several methods to treat corneal neovascularization have been tried; eg, argon laser photocoagulation and photodynamic therapy with different photosensitizers. 8 However, such therapies are associated with thermal damage to the cornea and a high rate of vessel recanalization. Pharmacological treatment of corneal neovascularization using angiogenic inhibitors has evolved as a new way to manage corneal neovascularization.…”

Section: Discussionmentioning

confidence: 99%

Subconjunctival bevacizumab for vascularized rejected corneal grafts

Awadein¹

2007

Journal of Cataract and Refractive Surgery

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We describe 3 patients who experienced corneal neovascularization following keratoplasty and were treated with a single subconjunctival injection of 2.5 mg bevacizumab. Although there was immediate regression of the corneal vascularization and haze, as well as improvement in the anterior chamber reaction, the effects were short-lived and starting from the second week, the corneal vessels began to progress. All 3 cases ended in permanent graft failure. The series suggests a possible role for bevacizumab in the management of graft rejection with vascularization.

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Section: Discussionmentioning

confidence: 99%

Subconjunctival bevacizumab for vascularized rejected corneal grafts

Awadein¹

2007

Journal of Cataract and Refractive Surgery

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“…It is known that ATXS10Na(II) is cleared from the body very rapidly. The half life in plasma is approximately 45 min [27]. regime.…”

Section: Discussionmentioning

confidence: 99%

The vascular response to photodynamic therapy with ATX-S10Na(II) in the normal rat colon

Harada

Woodhams

MacRobert

et al. 2005

Journal of Photochemistry and Photobiology B: Biology

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“…Currently, argon laser photocoagulation and photodynamic therapy with different photosensitizers or corticosteroids are used to treat corneal neovascularization. 9,10,20 Although these therapies generally improve vision, they are not ideal treatments because of vessel recanalization, thermal damage to adjacent tissues, possible worsening of the lesion, ocular hypertension, and cataract progression. More effective prevention or treatment strategies are therefore desirable.…”

Section: Discussionmentioning

confidence: 99%