Photodynamic endometrial ablation in the nonhuman primate

Abstract

This is the first report of endometrial destruction in the primate using a photodynamic approach. Whereas clinical application of photodynamic therapy (PDT) requires complete endometrial ablation to produce long-lasting amenorrhea, our results suggest that PDT may offer a simple office-based approach to endometrial ablation.

Photodynamic endometrial ablation: Morphological study

“…In contrast to endometrial ablation by heat, photodynamic therapy (PDT) provides a photooxidation-induced, selective endometrial tissue destruction. Studies in rats, rabbits, and primates report the feasibility of selective photodynamic damage of the endometrium [5][6][7][8][9][10][11][12][13][14][15][16]. The process typically involves topical administration of a photosensitizing drug.…”

Photodynamic endometrial ablation for the treatment of dysfunctional uterine bleeding: A preliminary report

“…Both, drug and light can easily be administered using topical sensitizers and transvaginal optical balloon illumination. Studies in rats, rabbits, and primates showed that various photosensitizers localize selectively in the endometrium following systemic or topical application and that irradiation with light of appropriate wavelength causes selective photodynamic destruction of the endometrium [4][5][6][7]. Success of any endometrial ablation method depends on prevention of endometrial regeneration by elimination of proliferating stem cells at the endometrial-myometrial junction and in residual gland stumps [4,19].…”

“…In contrast to endometrium damaging by heat, photodynamic therapy provides a photooxidation-based, selective endometrium destruction. Studies in rats, rabbits, and primates show that selective photodynamic damage of the endometrium is feasible [3][4][5][6][7]. The process typically involves topical administration of a photosensitizing drug.…”

Endometrial Ablation: Where Have We Been? Where Are We Going?

“…Successful destruction of endometrium with photosensitive agents has been reported in rat, rabbit, and monkey models. [113][114][115] The systemic or local pretreatment of target tissues such as endometrium with agents activated by monochromatic light can produce a local cytotoxic effect. For each photosynthesizer molecule, a specific wavelength (usually laser light), accurately matched to the absorption peak, must be used to produce local tissue necrosis.…”