Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma

Onoyama, Masaki; Tsuka, Takeshi; Imagawa, Tomohiro; Osaki, Tomohiro; Minami, Saburo; Aso, Kazuo; Kawashima, Kazuhiko; Ishi, Hiroshi; Takayama, T.; Ogawa, Nobuhiko; Okamoto, Yoshiharu

doi:10.4142/jvs.2014.15.1.117

Cited by 13 publications

(5 citation statements)

References 31 publications

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“…The present study revealed that combination therapy consisting of conservative surgery and PHCT in FVAS prevented recurrence of the tumor in the cases that had undergone no or one previous surgical resection. These results were comparable to those of a previous study ( 15 ).…”

Section: Discussionsupporting

confidence: 91%

“…The PHCT procedure was performed as previously reported ( 15 ) under general anesthesia with isoflulene (DS Pharma Animal Health Co., Ltd., Osaka, Japan). In brief, ICG (25 mg/vial; Giagnogreen; Daiich Sankyo Co. Ltd, Tokyo, Japan) was dissolved in 9 ml saline (Otsuka Pharmacy, Co., Ltd., Tokyo, Japan) with an adjusted pH of 5.0.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies by the current authors have investigated the anticancer effects of PHT in experiments in vitro ( 12 ) and in vivo ( 13 ) and it has been demonstrated that the effects of local chemotherapy were enhanced by HT ( 14 ). Subsequently, a method was developed using local chemotherapy in combination with PHT, entitled photodynamic hyperthermal chemotherapy (PHCT), which has previously demonstrated positive results in the treatment of spontaneous soft tissue sarcomas in dogs and cats ( 15 ). The present study investigated the therapeutic effects of PHCT in six cases of FVAS.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic hyperthermal chemotherapy with indocyanine green in feline vaccine-associated sarcoma

Onoyama¹,

Tsuka

Imagawa

et al. 2015

Oncology Letters

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The anticancer effects of photodynamic hyperthermal chemotherapy (PHCT), which consists of a combination of indocyanine green photodynamic hyperthermal therapy and local chemotherapy, have previously been reported. The present study investigated the effect of PHCT in six cases of feline vaccine-associated sarcoma (FVAS) following conservative surgical resection. No recurrence was observed in three out of six (50%) cases, while recurrence was observed in the remaining three cases. Of note, each feline with recurrences had previously undergone surgical resection more than three times, whereas those without recurrence had undergone no or one previous resection. In addition, the three animals in which there was no recurrence survived between 893 and 1,797 days following surgery. In conclusion, the results of the present study suggested that PHCT may be a candidate as a novel adjuvant cancer therapy for FVAS.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Photodynamic hyperthermal chemotherapy with indocyanine green in feline vaccine-associated sarcoma

Onoyama¹,

Tsuka

Imagawa

et al. 2015

Oncology Letters

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“…In such contest, PDS and PDT may be of great advantage, allowing a thorough excision, thereby reducing the extent of the excision area and postoperative morbidity. PDT has already been studied in FISS, based on the use of indocyanine green combined to hyperthermal chemotherapy following conservative surgical resection [52]. In our series, cats were treated with acridine orange-based PDS and PDT, a treatment already tested in different pilot studies on malignant musculoskeletal tumors in humans [8, 41, 53–55].…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Surgery for Feline Injection-Site Sarcoma

Martano

Morello

Avnet

et al. 2019

BioMed Research International

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Musculoskeletal sarcomas are rare and aggressive human malignancies affecting bones and soft tissues with severe consequences, in terms of both morbidity and mortality. An innovative technique that combines photodynamic surgery (PDS) and therapy (PDT) with acridine orange has been recently suggested, showing promising results. However, due to the low incidence of sarcoma in humans, this procedure has been attempted only in pilot studies and stronger evidence is needed. Naturally occurring tumors in cats are well-established and advantageous models for human cancers. Feline injection-site sarcoma (FISS) shares with human musculoskeletal sarcomas a mesenchymal origin and an aggressive behavior with a high relapse rate. Furthermore, wide surgical excision is not always possible due to the size and site of development. We assessed the feasibility and the effectiveness of PDS and PDT with acridine orange to prevent FISS recurrence by treating a short case series of cats. For PDS, the surgical field was irrigated with an acridine orange solution and exposed to UV light to enlighten the residual tumor tissue, and the resultant fluorescent areas were trimmed. For PDT, before wound closure, the field was again irrigated with acridine orange solution and exposed to visible light to get the antitumoral cytocidal effect. The procedure was easy to perform and well tolerated, we did not observe any major complications, and all the surgical resection margins were free of disease. Finally, at follow-up, all treated patients did not show evidence of tumor recurrence and had a significantly higher event-free survival rate in respect to a control group treated only by surgery. In conclusion, by this study we demonstrated that, in FISS, PDS and PDT with acridine orange may improve local tumor control, granting a better outcome, and we laid the foundation to validate its effectiveness for the treatment of human musculoskeletal sarcomas.

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“…Photodynamic hyperthermal therapy (PHT) (16,17), photodynamic hyperthermal CT (PHCT) (18,19) and CT were performed, with lupeol administered as an adjuvant therapy. PHT is a local treatment combining photo- ---187 187 Alive C06 II Partial ---180 180 Alive C07 II Partial PHCT --120 420 Alive C08 II Partial ---201 201 Alive C09 III Partial ---248 248 Alive C10 III Partial PHT --189 189 Alive C11 III Partial ---39 39 Alive DFT, disease-free time; ST, survival time; PHCT, photodynamic hyperthermal chemotherapy; PHT, photodynamic hyperthermal therapy.…”

Section: Subjectsmentioning

confidence: 99%

Clinical systemic lupeol administration for canine oral malignant melanoma

Yokoe¹,

Aso²,

Hata³

et al. 2014

Molecular and Clinical Oncology

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Abstract. Canine oral malignant melanoma (COMM) is the most aggressive malignant tumor in dogs. Lupeol is a triterpene extracted from various fruits and vegetables that reportedly inhibits melanoma cell proliferation in vitro and in vivo. In this study, the efficacy of subcutaneous lupeol for spontaneous COMM was evaluated. A total of 11 dogs (3, 5 and 3 dogs diagnosed with clinical stage I, II and III melanoma, respectively) were evaluated. Subcutaneous lupeol (10 mg/kg) was administered postoperatively at various time points to treat these 11 COMM cases. Of the 11 subjects, 7 exhibited no local recurrence 180 days postoperatively and no severe adverse effects were observed in any of the cases. Furthermore, no distant metastasis was observed during the experimental period. Therefore, systemic lupeol may prevent local tumor progression and distant metastasis and may be a novel adjuvant treatment for the treatment of COMM. IntroductionCanine oral malignant melanoma (COMM) is the most common malignancy in dogs, accounting for 30-40% of all oral tumors (1,2). COMM is characterized by extensive local invasion, as well as distant metastasis (2). Melanoma treatment includes radiation therapy and chemotherapy (CT), either alone, as an adjuvant therapy following surgery, or in combination (2). Although radiation therapy provides effective local tumor control, it is only performed in selected facilities (3-5).In addition, radiation therapy may be costly and, hence, beyond the financial means of some owners. Several reports have investigated the efficacy of CT in COMM, but there is no definitive evidence regarding its effectiveness (5,6,7-9). Therefore, there is a need for an alternative treatment for COMM.Lupeol is a triterpene found in fruits such as olives, mangoes, strawberries, grapes and figs, numerous vegetables and several medicinal plants (10). Previous studies reported that lupeol has antitumor properties (11,12) and several reports indicated that lupeol inhibits melanoma cell proliferation in vitro and in vivo (13,14). Recently, Nitta et al (14) reported that systemic lupeol administration inhibited tumor growth in a melanoma-bearing mouse model; however, there is no report evaluating its clinical efficacy in COMM. In this study, we aimed to evaluate the efficacy of subcutaneous lupeol as an adjuvant therapy for spontaneous COMM. Subjects and methods Subjects.A total of 11 dogs were included in this study. The characteristics of the sublects are summarized in Table I. The represented breeds included 2 miniature Dachshunds, 2 Beagles, 2 miniature Schnauzers, 1 Golden Retriever, 1 Labrador Retriever, 1 American Cocker Spaniel, 1 Cavalier King Charles Spaniel and 1 mixed-breed dog. The dogs ranged in age between 8 and 17 years. The tumors in all 11 dogs were classified according to the TNM classification (1,2) as follows: 3 dogs had stage I, 5 dogs had stage II and 3 dogs had stage III disease (Table I). Two cases of cancer recurrence were included (C04 and C07). This study was conducted between April, 2010 and M...

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Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma

Cited by 13 publications

References 31 publications

Photodynamic hyperthermal chemotherapy with indocyanine green in feline vaccine-associated sarcoma

Photodynamic hyperthermal chemotherapy with indocyanine green in feline vaccine-associated sarcoma

Photodynamic Surgery for Feline Injection-Site Sarcoma

Clinical systemic lupeol administration for canine oral malignant melanoma

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