“…The approach is based on the use of a photosensitizer (PS) that binds to the surface or preferentially accumulates in the target fungal cell (13,14,17,20). Subsequent exposure of the PS to light of an appropriate wavelength starts a photochemical process that produces several reactive oxygen species (ROS), such as peroxides and singlet oxygen, leading to nonspecific oxidative damage and causing the subsequent death of the fungal cells without significant harm to the host (14,19,20). In comparison with currently used fungicides, the multiple and variable targets of reactive oxygen species reduce the chance of selecting tolerant microorganisms.…”