Photodynamic inactivation of influenza virus with fullerene C60 suspension in allantoic fluid

Zarubaev, Vladimir V.; Белоусова, И. М.; Киселев, О. И.; Piotrovsky, L. B.; Anfimov, Pavel; Krisko, Tatyana C.; Muraviova, Tatyana D.; Rylkov, V. V.; Starodubzev, A.; Sirotkin, Alexey

doi:10.1016/j.pdpdt.2006.08.003

Cited by 34 publications

(19 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fullerenes solution can inactivate influenza virus in the allantoic fluid of chicken embryo with high efficiency and damage the viral envelope [6] , which might be due to the capacity of passing electrons through lipid double membrane. The direct inactivation of the NCFL against virus may be attributed to this mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…Inhibitory rate of the virus was calculated according to the following formula [5] : Virus inhibitory rate=(Average A 570 in experimental groupˉAverage A 570 in viral control group)/(Average A 570 in cell control groupˉAverage A 570 in viral control group)×100% [6] . Value of 50% inhibitory concentration (IC 50 ) could be calculated according to the Reed-Muench method [5] .…”

Section: Antiviral Activity Of the Ncfl In Vitromentioning

confidence: 99%

See 1 more Smart Citation

Antiviral activity of nano carbon fullerene lipidosome against influenza virus in vitro

Yang

Jiang³

et al. 2008

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

View full text Add to dashboard Cite

The activity of nano carbon fullerene lipidosome (NCFL) against influenza virus H1N1 in vitro was studied by observing the cytotoxicities and its activity rendered by different intensities of lighting with various periods of time. Rimantadine hydrochloride was used as the positive control drug. By using microcultural technique, the morphological changes of cells were observed and by using the gentian violet staining, antiviral activity of the NCFL against influenza virus was assayed. The results showed that: (1) The maximal concentration of the NCFL was 7 microg/mL and the 50% toxic concentration (TC(50)) was 13.54 microg/mL respectively; (2) NCFL had a significant activity of directly killing the influenza virus, while the activities in antiadsorption and antireplication were not obvious; (3) There was a dose-activity relationship between the dosages of NCFL and the direct killing effect against the influenza virus, and the periods of lighting-time could influence the activity partly. It was concluded that NCFL had a significant activity of directly killing the influenza virus.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Antiviral Activity Of the Ncfl In Vitromentioning

confidence: 99%

Antiviral activity of nano carbon fullerene lipidosome against influenza virus in vitro

Yang

Jiang³

et al. 2008

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

View full text Add to dashboard Cite

show abstract

“…It was found that dramatic drop of infectious titer of the influenza virus (H1N1) was observed with irradiation after C 60 fullerene treatment in allantoic fluid of chicken embryos. C 60 didn't possess a specific affinity to the virions and it seemed that ROS was contributed for it [44]. Hepatitis C virus (HCV) inhibition effects of three fullerenes derivatives were not significantly different [38].…”

Section: Anti-virus Activitymentioning

confidence: 99%

Fullerenes as unique nanopharmaceuticals for disease treatment

Liang

2010

Sci. China Chem.

View full text Add to dashboard Cite

As unique nanoparticles, fullerenes have attracted much attention due to their unparalleled physical, chemical and biological properties. Various functionalized fullerenes with OH, NH 2 , COOH, and peptide modifications were developed. It summarized the biological activities of fullerenes derivatives in cancer therapy with high efficiency and low toxicity, as reactive oxygen species scavenger and lipid peroxidation inhibitor, to inhibit human immunodeficiency virus and to suppress bacteria and microbial at low concentration. In addition, the mechanism for fullerene to enter cells and biodistribution of fullerene in vivo was also discussed. This research focuses on the current understanding of fullerenes-based nanomaterials in the potential clinical application as well as biological mechanism of fullerenes and its derivatives in disease therapy. fullerene, nanoparticle, nanomedicine, clinical application, biological effect

show abstract

“…The viruses lose their infectivety more than 7 lg ID 50 during a few hours of photoinactivation with C 60 fullerenes [5,6]. That is why the purpose of this work is to study the interaction of photoactivated C 60 fullerenes with the virions of mosquito iridovirus, isolated from the mosquito larvae Aedes flavescens.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic inactivation of mosquito iridovirus (MIV) by C₆₀ fullerenes

Rud¹,

Prylutska

Buchatskyy

et al. 2011

Materialwissenschaft Werkst

View full text Add to dashboard Cite

It was shown that water soluble C 60 fullerenes under visible light interact with iridovirus virions of mosquito Aedes flavescens and lead to their destruction. Specifically, the photodynamic inactivation of mosquito iridovirus during 1 h reduced the infectious virus titer in large wax-moth larvae Galleria mellonella on 4 lg ID50/ml. Therefore, for inactivation of iridoviruses in biological systems it is appropriate to use the photoexcited C 60 fullerenes.

show abstract

Photodynamic inactivation of influenza virus with fullerene C60 suspension in allantoic fluid

Cited by 34 publications

References 6 publications

Antiviral activity of nano carbon fullerene lipidosome against influenza virus in vitro

Antiviral activity of nano carbon fullerene lipidosome against influenza virus in vitro

Fullerenes as unique nanopharmaceuticals for disease treatment

Photodynamic inactivation of mosquito iridovirus (MIV) by C₆₀ fullerenes

Contact Info

Product

Resources

About

Photodynamic inactivation of influenza virus with fullerene C60 suspension in allantoic fluid

Cited by 34 publications

References 6 publications

Antiviral activity of nano carbon fullerene lipidosome against influenza virus in vitro

Antiviral activity of nano carbon fullerene lipidosome against influenza virus in vitro

Fullerenes as unique nanopharmaceuticals for disease treatment

Photodynamic inactivation of mosquito iridovirus (MIV) by C60 fullerenes

Contact Info

Product

Resources

About

Photodynamic inactivation of mosquito iridovirus (MIV) by C₆₀ fullerenes