Photodynamic performance of zinc phthalocyanine in HeLa cells: A comparison between DPCC liposomes and BSA as delivery systems

Garcia, Angélica M.; Weerasekera, Hasitha de Alwis; Pitre, Spencer P.; McNeill, Brian; Lissi, E. A.; Edwards, A.; Alarcon, Emilio I.

doi:10.1016/j.jphotobiol.2016.09.002

Cited by 36 publications

(15 citation statements)

References 34 publications

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“…Following these studies, other examples of BSA/HSA-Pc conjugates have been described in the literature. [120][121][122][123] As an interesting case, a Zn(II)Pc was linked to a bifunctional protein containing HSA and an amino-terminal fragment of urokinase (ATF). 124 ATF binds to the urokinase receptor, which appears with high expression levels in tumoral cells, and so this conjugate could serve as a dual-mode PDT and imaging agent (Fig.…”

Section: Hybrids With Serum Proteinsmentioning

confidence: 99%

Porphyrinoid biohybrid materials as an emerging toolbox for biomedical light management

et al. 2018

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The development of photoactive and biocompatible nanomaterials is a current major challenge of materials science and nanotechnology, as they will contribute to promoting current and future biomedical applications. A growing strategy in this direction consists of using biologically inspired hybrid materials to maintain or even enhance the optical properties of chromophores and fluorophores in biological media. Within this area, porphyrinoids constitute the most important family of organic photosensitizers. The following extensive review will cover their incorporation into different kinds of photosensitizing biohybrid materials, as a fundamental research effort toward the management of light for biomedical use, including technologies such as photochemical internalization (PCI), photoimmunotherapy (PIT), and theranostic combinations of fluorescence imaging and photodynamic therapy (PDT) or photodynamic inactivation (PDI) of microorganisms.

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Section: Hybrids With Serum Proteinsmentioning

confidence: 99%

Porphyrinoid biohybrid materials as an emerging toolbox for biomedical light management

et al. 2018

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“…Phototoxicity of some Zn(II)Pcs has already been tested against cervical and oral skin squamous carcinoma cells in in vitro experiments. However, due to the aggregation problems they present, it is necessary to transport them through complex conjugates [26][27][28]. Herein, we have studied the activity of ABAB-1, A 3 B-1 Table 2 indicate that neither the presence of the Zn(II)Pc at these concentrations, nor the administration of red light, induced significant cytotoxic effects in the cell lines studied, and survival rates above 95% were obtained.…”

Section: Cytotoxicity Studiesmentioning

confidence: 96%

Assessing Amphiphilic ABAB Zn(II) Phthalocyanines with Enhanced Photosensitization Abilities in In Vitro Photodynamic Therapy Studies Against Cancer

et al. 2020

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We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., bis(trifluoromethyl)phenyl units) at facing positions of ABAB Zn(II)Pcs, where A and B refer to differently functionalized isoindoles. In this work, we have prepared the Zn(II)Pc ABAB 1 endowed with hydrophilic triethylene glycol monomethyl ether (i.e., at the A isoindoles) to provide solubility in aqueous media, together with its A3B and A4 counterparts, and compared their ability to behave as photosensitizers for photodynamic therapy. All photophysical data, aggregation studies and preliminary in vitro biological assays in cell cultures of SCC-13 (squamous cell carcinoma) and HeLa (cervical cancer cells), have proved ABAB 1 as the best photosensitizer of the series.

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“…The increased extension of the macrocyle, which is hydrophobic in nature, favors the formation of large aggregates in polar solvent and in some cases renders the compound practically insoluble in aqueous media. As a consequence their delivery to cells in vitro and in vivo is possible after inclusion in lipidbased formulations or nanovectors with a hydrophobic core [26][27][28][29][30].…”

Section: Ideal Properties Of Photosensitizers For Pdtmentioning

confidence: 99%

Strategies for optimizing the delivery to tumors of macrocyclic photosensitizers used in photodynamic therapy (PDT)

Moret

Reddi

2017

J. Porphyrins Phthalocyanines

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This review briefly summaries the principles and mechanisms of action of photodynamic therapy (PDT) as concerns its application in the oncological field, highlighting its drawbacks and some of the strategies that have been or are being explored to overcome them. The major aim is to increase the efficiency and selectivity of the photosensitizer (PS) uptake in the cancer cells for optimizing the PDT effects on tumors while sparing normal cells. Some attempts to achieve this are based on the conjugation of the PS to biomolecules (small ligands, peptides) functioning as carriers with the ability to efficiently penetrate cells and/or specifically recognize and bind proteins/receptors overexpressed on the surface of cancer cells. Alternatively, the PS can be entrapped in nanocarriers derived from various types of materials that can target the tumor by exploiting the enhanced permeability and retention (EPR) effects. The use of nanocarriers is particularly attractive because it allows the simultaneous delivery of more than one drug with the possibility of combining PDT with other therapeutic modalities.

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Photodynamic performance of zinc phthalocyanine in HeLa cells: A comparison between DPCC liposomes and BSA as delivery systems

Cited by 36 publications

References 34 publications

Porphyrinoid biohybrid materials as an emerging toolbox for biomedical light management

Porphyrinoid biohybrid materials as an emerging toolbox for biomedical light management

Assessing Amphiphilic ABAB Zn(II) Phthalocyanines with Enhanced Photosensitization Abilities in In Vitro Photodynamic Therapy Studies Against Cancer

Strategies for optimizing the delivery to tumors of macrocyclic photosensitizers used in photodynamic therapy (PDT)

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