Photodynamic Response of a New Tetracycline

Carey, Benjamin W.

doi:10.1001/jama.1960.03020110080021

Cited by 13 publications

(3 citation statements)

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“…The discolouration of nails observed in one of the study candidates after eight weeks of oral taking of the drug is not an alarming event. Similar reaction has been observed in subjects taking tetracycline for even a short course when exposed to direct sunlight (Carey, 1960;Horio, 1988;Bjellerup & Ljunggren, 1994). Although the direct sunlight toxic effects have been experienced in white skin races, it is not clear whether this type of reaction is common among black skin races.…”

Section: Discussionsupporting

confidence: 69%

“…Gastrointestinal tract adverse reactions (nausea, vomit, abdominal pain and anorexia), are not uncommon phenomena in many drugs including the antibiotics, therefore, one should anticipate such reactions when treating patients with the drug. Ansonia, rash, itching, jaundice, atypical lymphocytosis and thrombopenic purpuras (Carey, 1960) are some of the rare unwanted effects associated with administration of the drug. These serious adverse events were not experienced in our study subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to sunlight for a long period on doxycycline or tetracycline has been associated with photo-toxicity reaction; onycholysis and pigmentation of the nails developing simultaneously at all ages (Horio, 1988). These reactions can occur when the skin is exposed to sunlight rays in the range of 270-320nm (Carey, 1960). Although rarely, doxycycline can precipitate pre-existing renal failure.…”

Section: Introductionmentioning

confidence: 99%

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Hospital-based safety and telerability study to assesss efficacy of oral doxycycline in the treatment of <i> Wuchereria bancrofti infection in north-eastern Tanzania

Makunde¹,

Kamugisha²,

Makunde³

et al. 2009

Tanzania J Hlth Res

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A hospital based open-label clinical trial of 19 apparently healthy adult males with microfilaraemia was conducted to assess safety, tolerability and efficacy of doxycycline on Wuchereria bancrofti. Study individuals were assigned 8 weeks treatment with doxycycline 200 mg daily. The results of different selected tests showed that, the haematological, hepatic, renal and clinical parameters pre-and post-drug administrations were within the normal range for all treated individuals. Clinical adverse events were mild, transient, tolerable and reported in 7/19 (36.8%) of the study cohort. The mf clearance rate was 100% at 12 months post treatment for the 13 individuals who completed the follow up. These findings indicate that, although the drug was administered for a long period, there was no evidence of toxicity to the myocardium, hepatocytes, renal, bone marrow and blood cells, suggesting that an 8-week course of 200 mg/day doxycycline is a safe and tolerable regime for the treatment of Wuchereria bancrofti infections.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%