Photodynamic theranostics of central lung cancer: Present state and future prospects

Akopov, Andrey; Papayan, G. V.

doi:10.1016/j.pdpdt.2021.102203

Cited by 9 publications

(9 citation statements)

References 46 publications

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“…Among the most important advantages of PDT is low systemic toxicity because the cytotoxic effect of the PS in the absence of light irradiation is several orders of magnitude lower than in the irradiated cancer tissue. But a current limitation is the mode of light delivery, which is currently restricts treatment to superficial tumors or tumors accessible with an endoscope: non-melanoma skin cancer [ 206 ], retina and ocular malignancies [ 207 ], cancer of the digestive tract [ 208 ], urinary system malignancies [ 209 , 210 ], tracheobronchial malignancies [ 211 ], and cervical cancer [ 212 ]. Also, PDT was shown to be effective in improving patient prognosis when used after surgical resection of glioblastoma [ 213 , 214 ].…”

Section: Introductionmentioning

confidence: 99%

Which cell death modality wins the contest for photodynamic therapy of cancer?

et al. 2022

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Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed for the treatment of several types of cancer. Traditionally, cell death induced by PDT was categorized into three types: apoptosis, cell death associated with autophagy, and necrosis. However, with the discovery of several other regulated cell death modalities in recent years, it has become clear that this is a rather simple understanding of the mechanisms of action of PDT. New observations revealed that cancer cells exposed to PDT can pass through various non-conventional cell death pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, and ferroptosis. Nowadays, immunogenic cell death (ICD) has become one of the most promising ways to eradicate tumor cells by activation of the T-cell adaptive immune response and induction of long-term immunological memory. ICD can be triggered by many anti-cancer treatment methods, including PDT. In this review, we critically discuss recent findings on the non-conventional cell death mechanisms triggered by PDT. Next, we emphasize the role and contribution of ICD in these PDT-induced non-conventional cell death modalities. Finally, we discuss the obstacles and propose several areas of research that will help to overcome these challenges and lead to the development of highly effective anti-cancer therapy based on PDT.

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Section: Introductionmentioning

confidence: 99%

Which cell death modality wins the contest for photodynamic therapy of cancer?

et al. 2022

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“…We have developed and studied a fluorescent technique for PDT efficiency control, it enables to combine diagnostic and treatment components within a procedure, and therapeutic intervention parameters can be corrected on a real-time basis depending on diagnostic information obtained [ 30 , 39 ]. Such approach suitable to personalization tendency in current medicine can be considered as theranostics (therapy + diagnostics) variant and called photodynamic theranostics.…”

Section: Theranostic Approachmentioning

confidence: 99%

“…It is rather complicated to explain the present effect, when it was possible to speed up ICG imaging of bronchial tumors, since in case of other tumor sites both in experiments [ 53 ] and under clinical conditions [ 58 ] the procedure failed. For ICG fluorescence imaging, the above-described video bronchoscopic system was upgraded by using a laser, 808-nm wavelength, as well as the elements necessary to record NIR fluorescence [ 39 , 59 ].…”

Section: Theranostic Approachmentioning

confidence: 99%

“…Particular interest is provoked by a series of clinical experiments on administering two fluorescent agents to a patient: Radachlorin (2 h before examination) and ICG (during bronchoscopy, 1 min prior to fluorescent imaging) [ 39 ]. Contrast ICG fluorescence ( Figure 2 (а) ) can image all tumor nodes, which are detected using Radachlorin alone ( Figure 2 (b) ).…”

Section: Theranostic Approachmentioning

confidence: 99%

“…The feature of using ICG in the present study consists in the fact that NIR imaging was performed at minimal ICG doses, the agent is administered during the examination. The technique was suggested to be called on-site bronchoscopic photodynamic theranostics (OS-BPT) in order to distinguish it from the techniques using larger intervals between agent administration and imaging initiation [ 39 ]. Early CLC screening prospects can be based on OS-BPT implementation.…”

Section: Theranostic Approachmentioning

confidence: 99%

See 2 more Smart Citations

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Papayan¹,

Akopov²

2021

Sovrem Tehnol Med

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The aim of the study was to assess the prospects for central lung cancer (CLC) screening using fluorescent diagnostics and its treatment by endobronchial photodynamic therapy (PDT).Bronchoscopic fluorescent diagnostics using chlorin e6 photosensitizers and a developed instrumental system enable to reveal tumor changes in large bronchi mucosa at early stages, and a developed PDT technique performed under fluorescent control helps achieve personalized treatment. Such an approach is considered as a theranostic technique -photodynamic theranostics.Central lung cancer screening requires a fluorescent dye characterized by availability and can be used directly within the examination. Indocyanine green can be used as a dye, its peculiarity is the necessity to excite and record fluorescence in the near-infrared (NIR) wavelength band. First experiments using NIR bands to diagnose a bronchoscopic system showed the detectability of tumor areas using on-site bronchoscopic photodynamic theranostics, which consists in NIR imaging of tumor foci when a standard dose of indocyanine green is administered during the examination.Conclusion. Further progress of early diagnostics and minimally invasive CLC therapy will be determined by the development of new photosensitizers, which should be characterized by a high absorption band in NIR area, quick accumulation in a tumor, high yield of single oxygen in NIR illumination, bright fluorescence, high potential in terms of the induction of an anti-tumor immune response.

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Photodynamic therapy‐induced precise attenuation of light‐targeted semicircular canals for treating intractable vertigo

Yang,

Zhao,

et al. 2024

Smart Medicine

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Vertigo is a common symptom of various diseases that affects a large number of people worldwide. Current leading treatments for intractable peripheral vertigo are to intratympanically inject ototoxic drugs such as gentamicin to attenuate the semicircular canal function but inevitably cause hearing injury. Photodynamic therapy (PDT) is a noninvasive therapeutic approach by precisely targeting the diseased tissue. Here, we developed a PDT‐based method for treating intractable peripheral vertigo in a mouse model using a polymer‐coated photosensitizer chlorin e6 excited by red light. We found that a high dose of PDT attenuated the function of both semicircular canals and otolith organs and damaged their hair cells. Conversely, the PDT exerted no effect on hearing function or cochlear hair‐cell viability. These results suggest the therapeutic potential of PDT for treating intractable peripheral vertigo without hurting hearing. Besides, the attenuation level and affected area can be precisely controlled by adjusting the light exposure time. Furthermore, we demonstrated the potential of this therapeutic approach to be minimally invasive with light irradiation through bone results. Thus, our PDT‐based approach for attenuating the function of the semicircular canals offers a basis for developing a less‐invasive and targeted therapeutic option for treating vertigo.

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Photodynamic theranostics of central lung cancer: Present state and future prospects

Cited by 9 publications

References 46 publications

Which cell death modality wins the contest for photodynamic therapy of cancer?

Which cell death modality wins the contest for photodynamic therapy of cancer?

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Photodynamic therapy‐induced precise attenuation of light‐targeted semicircular canals for treating intractable vertigo

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