Photodynamic therapy: a clinical reality in the treatment of cancer

Hopper, Colin

doi:10.1016/s1470-2045(00)00166-2

Cited by 512 publications

(369 citation statements)

References 31 publications

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“…The Foscan is considered 100-200 times more efficient than Photofrin in PDT. Foscan-PDT has received a European marketing authorisation for the palliative treatment of patients with advanced squamous cell carcinoma of the head and neck who have failed to prior therapies and are unsuitable for radiotherapy, surgery or systemic chemotherapy [20][21][22][23].…”

Section: Resultsmentioning

confidence: 99%

Combination of photodynamic therapy + immunotherapy + chemotherapy in murine leukiemia

Canti¹,

Calastretti²,

Bevilacqua³

et al. 2010

neo

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Photodynamic therapy (PDT) is a treatment for cancer based on the photosensitization of tumor cells by photosensitive drugs and their subsequent destruction on exposure to light of particular wavelength. The combination of drug uptake in malignant tissues and selective delivery of laser-generated light provides an effective therapy with efficient tumor citotoxicity and minimal normal tissue damage. Since immune response of the host is important in the control of tumor growth and spreading, PDT is able to increase the antitumor immunity. In our laboratory we examined the antitumor effect of combination of PDT,with photoactivated M-THPC ( meta-tetrahydroxyphenylchlorin, FOSCAN, Temoporphirin), adoptive immunotherapy, with immune lymphocytes, and chemotherapy on advanced murine tumors. Mice bearing L1210 tumor were treated at day +4 with Navelbine (NVB 1mg/Kg), at day +5,+6 with PDT (0.3mg/Kg of mTHPC and 100mW/cm2 x 200'' of exposure of laser light),and at day + 7 with immune lymphocytes(IL), collected from mice pretreated with PDT(2x10 7 cells). The results show that the combination NVB + PDT + IL demonstrates a significant synergistic antitumor effect while the chemotherapy treatment with low dose of the drug is uneffective. The same positive results were obtained with the combination of Cisplatin (CDDP 0.5mg/Kg), PDT and IL, while the CDDP treatment alone is completely uneffective. In conclusion, these results suggest that it is possible to completely cure animals bearing advanced tumors, with a combined therapy, PDT + adoptive immunotherapy + low dose chemotherapy.

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Section: Resultsmentioning

confidence: 99%

Combination of photodynamic therapy + immunotherapy + chemotherapy in murine leukiemia

Canti¹,

Calastretti²,

Bevilacqua³

et al. 2010

neo

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“…For cancers of the oral cavity, the function and appearance of the mouth can be preserved without sacrificing the efficacy of tumour control (Fan et al, 1997;Hopper, 2000). Photodynamic therapy does not have the cumulative toxicity associated with ionising radiation and can be applied safely to previously irradiated tissues.…”

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confidence: 99%

Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer

et al. 2004

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Interstitial photodynamic therapy (IPDT) is a technique for applying photodynamic therapy (PDT) to internal tumours using light delivered via fibres inserted percutaneously. This phase I -II study assessed the safety and efficacy of IPDT for patients with persistent or recurrent head and neck cancer unsuitable for further treatment with surgery, radiotherapy or chemotherapy, recruited for 'last hope' salvage treatment. Patients were sensitised with 0.15 mg kg À1 mTHPC (meso-tetrahydroxyphenyl chlorin) 4 days prior to light delivery from fibres inserted directly into the target tumour (20 J per site at 652 nm) under image guidance. In all, 45 patients were treated. Nine achieved a complete response. Five are alive and free of disease 10 -60 months later. Symptomatic relief (mainly for bleeding, pain or tumour debulking) was achieved in a further 24. The median survival (Kaplan -Meier) was 16 months for the 33 responders, but only 2 months for the 12 nonresponders. The only serious complication was a carotid blow out 2 weeks after PDT. No loss of function was detected in nerves encased by treated tumours. Interstitial photodynamic therapy provides worthwhile palliation with few complications and occasional long-term survivors for otherwise untreatable advanced head and neck cancers. It is a treatment option worth adding to those available to integrated head and neck oncology teams.

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“…The technique is simple, can commonly be carried out in outpatient clinics, and is highly acceptable to patients. It can be repeated to debulk large tumours progressively [25]. …”

Section: Fig 2 Récidive D'un Carcinome éPidermoïde Du Voile Du Palamentioning

confidence: 99%

Photodynamic therapy as salvage treatment for recurrent head and neck cancer

Gangloff

Phulpin

Cortese

et al. 2012

Med Buccale Chir Buccale

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-Head and neck cancers often lead to disfiguration or functional impairments after treatment. Local recurrence occurs in around 60% of cases and most of them can not be retreated. Photodynamic therapy (PDT) can be an alternative treatment. In a serie of 10 patients with recurrent squamous cell carcinoma of the head and neck that have failed prior therapies and are unsuitable for conventional curative therapy, PDT treatment has been used. Eight patients have shown complete cicatrisation. Seven patients were cured after the follow up period up to 53 months. Three patients died (one outside etiology). Quality of life was considered as very much for 6 out of 10 patients, quite a bit for 1 patient, a little for 2 patients and not at all for 1 patient. Clinical benefit was evaluated as very much for 6 patients out of 10, quite a bit for 2 patients, a little for 1 patient and not at all for 1 patient. PDT can be proposed to patients with head and neck cancer in palliative situation. It could be a therapeutic solution for selected cases with good outcomes. PDT offers patients a unique chance of remission and increased life expectancy compared with palliative treatments.Résumé -La thérapie photodynamique comme traitement de sauvetage pour les récidives des cancers des voies aéro-digestives supérieures. Les cancers de la tête et du cou conduisent souvent à des séquelles esthétiques ou fonctionnelles majeures après traitement. Des récidives locales sont observées dans environ 60 % des cas et la majorité ne peut pas être retraitée à nouveau. La thérapie photodynamique (PDT) peut être une possibilité de prise en charge alternative. Dans une série de 10 patients présentant une récidive d'un carcinome épidermoïde des voies aéro-digestives supérieures qui n'est plus accessible à traitement curatif conventionnel, la PDT a été utilisée. Huit patients ont montré une cicatrisation complète. Sept patients étaient considérés comme guéris après une période de surveillance allant jusqu'à 53 mois. Trois patients sont décédés (dont un d'une cause extérieure au contexte carcinologique). La qualité de vie a été considérée comme très bonne pour 6 patients sur 10, bonne pour 1 patient, moyenne pour 2 patients et mauvaise pour 1 patient. La PDT est une option thérapeutique qui peut être proposée aux patients atteints de cancers des voies aéro-digestives supérieures et placés en situation de prise en charge palliative. Cela pourrait être une possibilité de prise en charge pour des patients bien sélectionnés qui permettrait d'obtenir de bons résultats. La PDT a offert à ces patients une chance unique de rémission de la maladie et a amélioré indéniablement le taux de survie par rapport à la prise en charge palliative qui était la seule alternative.Key words: head and neck cancer / photodynamic therapy / salvage therapy / photosensitizers / squamous cell carcinoma

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Photodynamic therapy: a clinical reality in the treatment of cancer

Cited by 512 publications

References 31 publications

Combination of photodynamic therapy + immunotherapy + chemotherapy in murine leukiemia

Combination of photodynamic therapy + immunotherapy + chemotherapy in murine leukiemia

Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer

Photodynamic therapy as salvage treatment for recurrent head and neck cancer

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