Photodynamic therapy: a review of applications in neurooncology and neuropathology

Uzdensky, Anatoly B.; Berezhnaya, E. V.; Kovaleva, Vera; Neginskaya, Maria; Rudkovskii, M. V.; Sharifulina, Svetlana

doi:10.1117/1.jbo.20.6.061108

Cited by 17 publications

(9 citation statements)

References 80 publications

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“…Singlet molecular oxygen 1 O 2 became the focus of intense laboratory study since seminal papers by Mulliken of 1928. Important treatises were provided by many researchers see for instance reviews [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…The PDT is a technique developed to treat the ever-increasing global incidence of cancer [1][2][3][4]. Current PDT of cancer is based on the photodynamic effect (PDE) with resultant photosensitized cell damage (via apoptotic scenario and endothelial injuries for cancer cells) in the presence of light and oxygen.…”

Section: Introductionmentioning

confidence: 99%

“…Effect of NIR QD laser irradiation on cytosolic calcium (A) in HaCaT and HeLa cell lines. Plasma membrane ion channels activity in HaCaT cells before and after 1270nm laser pulse (B) and α-tocopherol (C).Imaging showed an apparent increase in the fluorescence ratio by more than 1 2. times forHaCaT and HeLa cells, registered immediately after the laser was on.…”

mentioning

confidence: 99%

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Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology

Semyachkina-Glushkovskaya

Sokolovski

Goltsov

et al. 2017

Progress in Quantum Electronics

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For over 55 years, laser technology has expanded from laboratory research to widespread fields, for example telecommunication and data storage amongst others. Recently application of lasers in biology and medicine presents itself as one of the emerging areas. In this review, we will outline the recent advances in using lasers for the generation of singlet oxygen, traditionally used to kill tumour cells or induce thrombotic stroke model due to damage vascular effects. Over the last two decade, completely new results on cerebrovascular effects of singlet oxygen generated during photodynamic therapy (PDT) have been shown alongside promising applications for delivery of drugs and nanoparticles into the brain for therapy of brain cancer. Furthermore, a "gold key" has been found to overcome the limitations of PDT, such as low light penetration and high toxicity of photosensitizers, by direct generation of singlet oxygen using quantum-dot laser diodes emitting in the near infrared (NIR) spectral range. It is our motivation to highlight these pioneering results in this review, to improve understanding of the biological role of singlet oxygen and to provide new perspectives for improving clinical application of laser based therapy in further research. Content 1 Introduction 2 2 Mechanism of triplet to singlet oxygen transition 4 2.1. Singlet oxygen generation in organic solution 5 2.2. Singlet oxygen generation in living cells 6 2.3. Cytosolic free calcium level and ion channel activity under laser pulse 8

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology

Semyachkina-Glushkovskaya

Sokolovski

Goltsov

et al. 2017

Progress in Quantum Electronics

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“…The physical properties of the hematoporphyrin as a photosensitizer were¯rst described in 1908, and its biological activity was demonstrated a few years later, in 1913, when a German physician, Meyer-Betz, injected himself 200 mg of hematoporphyrin and remained sensitive to light for 2 months. 20 In modern history, Dougherty, 21 Wilson, 22 Stepp, 14 Krasnovsky, 23 Uzdensky, 24 Zavadskaya, 25 Sha¯rstein, 26 Hasan 27 are well-known researchers in experimental and clinical studies of PDT.…”

Section: Photodynamic Therapy (Pdt) Of Brain Tumors: a Brief Historymentioning

confidence: 99%

Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics

Abdurashitov

Tuchin

Semyachkina-Glushkovskaya

2020

J. Innov. Opt. Health Sci.

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Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the treatment of brain tumors. The newly discovered PDT-induced opening of the blood–brain barrier (BBB) permeability open novel strategies for drug-brain delivery during post-surgical treatment of glioblastoma GBM. Here we discuss mechanisms of PDT-mediated opening of the BBB and age differences in PDT-related increase in BBB permeability, including with formation of brain edema. The meningeal lymphatic system plays a crucial role in the mechanism of brain drainage and clearance from metabolites and toxic molecules. We discuss that noninvasive photonic stimulation of fluid clearance via meningeal lymphatic vessels, and application of optical coherence tomography (OCT) for bed-side monitoring of meningeal lymphatic drainage has the promising perspective to be widely applied in both experimental and clinical studies of PDT and improving guidelines of PDT of brain tumors.

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“…However, the authors of these works pointed out the possibility of long-term side effects caused by accumulation of mutations due PDT (photodynamic therapy) is used in the treatment of different types of cancer: skin [1][2][3], esophageal [4,5], lungs [6][7][8], nervous system [9,10], female genital organs [11][12][13], biliary tract [14], head and neck [15][16][17]. However, the widespread usage of PDT in clinics is limited by a number of factors such as inefficient sources of singlet oxygen [18], low depth of penetration into human tissue [19], phototoxicity [20] and genotoxicity caused by DNA single strand breaks of leukocytes of blood [21,22].…”

Section: Introductionmentioning

confidence: 99%

DNA Damage after Ozone-Photodynamic Therapy in Cancer Animals: Experimental Research

Tatiana¹,

Irina²,

Evgeniya³

et al. 2017

JPP

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Abstract:Objectives: To assess the genotoxic effect of a new antitumor ozone-photodynamic therapy using the improved modification of the COMET assay. Methods: Xenograft cancer models on 58 rats were used. The sarcoma RA was transplanted subcutaneously, and after increasing of tumor volume from 0.5 to 4.2 cm 3 , rats were divided into the four groups: "Intact"-healthy,"Control"-with xenografted tumors and no treatment, "PDT"-the rats treated with the photodynamic therapy, "PDT + ozone"-the rats were treated with both photodynamic therapy and injections of ozonated saline solution. The toxicity of treatment was assessed by DNA damage in leukocytes using the new modification of the COMET assay. The analysis of the "COMETs" was performed following the percentage of DNA in the tail of the "COMET" (% TDNA). Results: A combination of PDT and ozone makes the strongest negative impact on tumor growth. The tumor growth inhibition is associated with low genotoxic exposure of ozone-photodynamic therapy on whole blood leukocytes of cancer rats. Conclusions: A new modification of the COMET assay can provide the assessment of the genotoxic effect of the antitumor therapy in experimental neoplasia.

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Photodynamic therapy: a review of applications in neurooncology and neuropathology

Cited by 17 publications

References 80 publications

Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology

Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology

Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics

DNA Damage after Ozone-Photodynamic Therapy in Cancer Animals: Experimental Research

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